When two or more
medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a
Drug Interaction.
Maxidol Liquid Gels Capsule may interact with drugs that
interfere with blood clotting system (
anticoagulants such as
warfarin or
heparin, antiplatelet drugs such as
aspirin, selective serotonin reuptake inhibitors, and
antidepressants). The use of Maxidol Liquid Gels with drugs that interfere with blood clotting system may increase the risk of adverse effects of stomach and intestine such as
bleeding,
ulcers, inflammation, and rupture (perforation) of the wall of the stomach, esophagus, large intestine, or small intestine. Also using Maxidol Liquid Gels with antidepressants such as serotonin-norepinephrine reuptake inhibitors may increase the risk of bleeding. Precaution along with monitoring of the bleeding in these patients should be considered. Maxidol Liquid Gels should not be recommended with
analgesic dose of aspirin.
There may be an interaction of
Maxidol Liquid Gels with antihypertensive drugs (angiotensin-II receptor blockers, angiotensin-converting
enzyme inhibitors,
methyldopa,
hydralazine, or
beta-blockers), which are used to treat high blood pressure. When Maxidol Liquid Gels is used with angiotensin-II receptor blockers, angiotensin-converting
enzyme inhibitors, methyldopa, hydralazine, or beta-blockers (including
propranolol), it may diminish the blood pressure lowering effect of these medicines. Elderly patients, patients with an abnormality in the functioning of the kidney or with loss of body fluid may experience reduced functioning of the kidney including kidney failure when using Maxidol Liquid Gels with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors. When
NSAIDs is used with angiotensin-II receptor blockers or angiotensin-converting enzyme inhibitors, it also increases the risk of the harmful effect of the kidney and high
potassium level. During combined use patients should be monitored for the established effect of anti-hypertensive agents. Elderly patients, patients with an abnormality in the functioning of the kidney or with the low level of body fluid should be monitored for the signs of worsening of the functioning of the kidney when using Maxidol Liquid Gels with angiotensin-II receptor blockers, or angiotensin-converting enzyme inhibitors. Hydration along with monitoring of the functioning of the kidney in the starting and periodically should be considered when using these drugs in combination.
Maxidol
Liquid Gels Capsule interacts with
diuretics (loop
diuretics, potassium-sparing diuretics, and thiazide diuretics), which are used to treat heart failure or high blood pressure. Non-steroidal anti-inflammatory drugs such as Maxidol Liquid Gels may decrease the prostaglandin
formation, precipitate the functioning of the kidney, decrease the
sodium excretion effect, and blood pressure lowering effect of diuretics such as
furosemide and thiazides. Elderly patients, patients with
liver failure, abnormal functioning of the kidney or heart, or taking diuretics may experience an increased risk of decreased functioning of the kidney and prostaglandin formation. Patients using Maxidol Liquid Gels with diuretics may experience an increased risk of
potassium levels in the blood and harmful effects of the kidney. Monitoring should be considered in patients using Maxidol Liquid Gels with diuretics. Also, monitoring of the functioning of the kidney should be considered in elderly patients, patients with liver failure, abnormal functioning of the kidney or heart, and taking diuretics. The lowest effective dose of Maxidol Liquid Gels should be recommended in patients with mild abnormal functioning of the kidney. Also, Maxidol Liquid Gels should not be used in patients with severe abnormal functioning of the kidney.
Special instructions need to be followed while taking this medicine along with cardiac glycosides (
digoxin), which are used to treat heart failure. When Maxidol
Liquid Gels is used with cardiac glycosides such as
digoxin, it may decrease the functioning of the kidney (glomerular filtration rate), increase the level of digoxin in the blood, or may increase the time required for the amount of drug in the body to decrease by one-half (half-life). The combined use of these medicines may also worsen heart failure. Monitoring of the level of digoxin in the blood should be considered in patients using Maxidol Liquid Gels with digoxin.
Your doctor's guidelines may need to be followed while taking this medicine along with
lithium, which is used to treat
depression. When Maxidol
Liquid Gels is used with
lithium, it may decrease the excretion and increase the levels of the lithium in the blood. Patients using Maxidol Liquid Gels with lithium should be monitored for the signs of harmful effects of the lithium.
Maxidol Liquid Gels Capsule may interact with cytotoxic drugs (
methotrexate), which are used to treat
cancer. When Maxidol Liquid Gels is used with methotrexate, it may decrease the excretion of methotrexate which may lead to harmful effects of methotrexate such as kidney failure, decreased levels of neutrophils and thrombocytes in the blood. Patients should be monitored for the harmful effects of methotrexate.
There may be an interaction of
Maxidol Liquid Gels with immunosuppressants (
ciclosporin or
tacrolimus), which are used to prevent organ rejection of the heart,
liver or kidney. When Maxidol Liquid Gels is used with
cyclosporin or tacrolimus, it may increase the risk of
cyclosporin or tacrolimus induced kidney damage. Patients using Maxidol Liquid Gels with immunosuppressants should be monitored for the signs of worsening of the functioning of the kidney.
Maxidol
Liquid Gels Capsule interacts with salicylates (
diflunisal,
salsalate) and nonsteroidal anti-inflammatory drugs, which are used to treat
pain and
stiffness of joints (
arthirits). The use of Maxidol Liquid Gels with salicylates or other nonsteroidal anti-inflammatory drugs may increase the risk of harmful effects of stomach and intestinal tract such as
bleeding,
ulcers, inflammation, and rupture (perforation) of the wall of the stomach, esophagus, large intestine, or small intestine. Patients should not use Maxidol Liquid Gels with other nonsteroidal anti-inflammatory drugs or salicylates.
Special instructions need to be followed while taking this medicine along with
pemetrexed, which is used to treat lung
cancer. When Maxidol
Liquid Gels is used with pemetrexed, it may increase the risk of pemetrexed induced decreased production of
platelets, red blood cells, or white blood cells, and harmful effects of the kidney, stomach or intestinal tract. When using Maxidol Liquid Gels with pemetrexed, patients with abnormal functioning of the kidney should be monitored for the harmful effects of the kidney, stomach or intestinal tract and for the decreased production of blood cells. Non-steroidal anti-inflammatory drugs with short elimination half-live such as
indomethacin and
diclofenac should be avoided for two days before, on the day of therapy, or after taking pemetrexed. In the case of non-steroidal anti-inflammatory drugs with long elimination half-live such as
nabumetone or
meloxicam, patients should avoid these medicines on the day of, five days before or two days after taking pemetrexed.
Your doctor's guidelines may need to be followed while taking this medicine along with
antacids (
aluminum hydroxide or
magnesium oxide) and
sucralfate, which are used to treat stomach
ulcers (duodenal ulcers). When Maxidol
Liquid Gels is used with
antacids (aluminum hydroxide or magnesium oxide) and sucralfate, it may decrease the absorption of Maxidol Liquid Gels. Patients should not use both medicines together.
Maxidol Liquid Gels Capsule may interact with anion-exchange resins such as
cholestyramine, which is used to treat severe
itching due to
liver or
bile duct disease. When Maxidol Liquid Gels is used with cholestyramine, it may decrease the absorption of Maxidol Liquid Gels. Patients should not use both medicines together.
Maxidol
Liquid Gels Capsule interacts with
probenecid, which is used to treat
pain, tenderness or redness of joints (
gout). When Maxidol Liquid Gels is used with probenecid, it may increase the level of Maxidol Liquid Gels. Also, it may increase the time required for the amount of medicine in the blood to decrease by one-half (half-life). Dose adjustment should be considered in patients using both medicines together.
Special instructions need to be followed while taking this medicine along with anti-diabetics (sulphonylureas) and antiepileptics (hydantoins), which are used to treat high blood
sugar and
epilepsy respectively. When Maxidol
Liquid Gels is used with sulphonylureas, it may increase the blood
sugar lowering effect of sulphonylureas. Also, using Maxidol Liquid Gels with hydantoins or sulphonylureas may increase the levels of these drugs in the body. Dose adjustment should be considered in patients using these medicines together. Also, such patients should be monitored for the increased levels of hydantoins and sulphonylureas in the body.
Your doctor's guidelines may need to be followed while taking this medicine along with antibacterials (
sulphonamides, quinolones, and aminoglycosides), which are used to treat bacterial infections. When Maxidol
Liquid Gels is used with quinolones such as
ciprofloxacin, it may increase the risk of convulsions. Also, using Maxidol Liquid Gels with aminoglycosides may increase the risk of harmful effects of the kidney. Dose adjustment along with monitoring of increased levels of sulphonamides should be considered in patients using Maxidol Liquid Gels with sulphonamides.
This page does not contain all the possible interactions of Maxidol Liquid Gels Capsule. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any
medicines without the approval of your doctor.