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Deep Brain Stimulation May Treat Multiple Sclerosis Tremors After All

Thursday, August 17, 2017 -- Deep brain stimulation (DBS) of the thalamus is a well-known treatment for tremor related to Parkinson’s disease, but the research surrounding its efficacy with multiple sclerosis tremors remains inconclusive. DBS of two thalamic nuclei was found to significantly decrease tremor severity over the course of 6 months in individuals with multiple sclerosis tremors.   Multiple […] The post Deep Brain Stimulation May Treat Multiple Sclerosis Tremors After All appeared first on Medical News Bulletin.

House Democrats Start Multiple Sclerosis Drug Price Probe

Thursday, August 17, 2017 -- The average annual cost of therapy had increased to more than $60,000 from about $16,000.

Diffusional Kurtosis Imaging of the Corticospinal Tract in Multiple Sclerosis: Association with Neurologic Disability [ADULT BRAIN]

Monday, August 14, 2017 -- BACKGROUND AND PURPOSE: Multiple sclerosis is an autoimmune disorder resulting in progressive neurologic disability. Our aim was to evaluate the associations between diffusional kurtosis imaging–derived metrics for the corticospinal tract and disability in multiple sclerosis. MATERIALS AND METHODS: Forty patients with MS underwent brain MR imaging including diffusional kurtosis imaging. After we masked out T2 hyperintense lesions, the fractional anisotropy, mean diffusivity, radial diffusivity, axial diffusivity, mean kurtosis, radial kurtosis, and axial kurtosis were estimated for the corticospinal tract. Disability was quantified by using the Expanded Disability Status Scale at the time of MR imaging and 12 months post-MR imaging. The Pearson correlation coefficient and linear regression analyses were conducted to evaluate the associations between diffusion metrics and disability.

Volumetric Analysis from a Harmonized Multisite Brain MRI Study of a Single Subject with Multiple Sclerosis [ADULT BRAIN]

Monday, August 14, 2017 -- BACKGROUND AND PURPOSE: MR imaging can be used to measure structural changes in the brains of individuals with multiple sclerosis and is essential for diagnosis, longitudinal monitoring, and therapy evaluation. The North American Imaging in Multiple Sclerosis Cooperative steering committee developed a uniform high-resolution 3T MR imaging protocol relevant to the quantification of cerebral lesions and atrophy and implemented it at 7 sites across the United States. To assess intersite variability in scan data, we imaged a volunteer with relapsing-remitting MS with a scan-rescan at each site. MATERIALS AND METHODS: All imaging was acquired on Siemens scanners (4 Skyra, 2 Tim Trio, and 1 Verio). Expert segmentations were manually obtained for T1-hypointense and T2 (FLAIR) hyperintense lesions. Several automated

Jugular Anomalies in Multiple Sclerosis Are Associated with Increased Collateral Venous Flow [EXTRACRANIAL VASCULAR]

Monday, August 14, 2017 -- BACKGROUND AND PURPOSE: To date, research on extracranial venous collaterals has been focused on structure, with relatively little attention paid to hemodynamics. We addressed this limitation by quantitatively comparing collateral flow in patients with multiple sclerosis and healthy controls by using phase-contrast MR imaging. We hypothesize that patients with MS with structurally anomalous internal jugular veins will have elevated collateral venous flow compared with healthy controls. MATERIALS AND METHODS: The sample consisted of 276 patients with MS and 106 healthy controls. We used MRV to classify internal jugular veins as stenotic and nonstenotic based on an absolute cross-sectional area threshold in 276 patients with MS and 60 healthy controls; 46 healthy controls lacked this imaging. Individual and total vessel

Neurology Mastery in Multiple Sclerosis: Treatment Persistence with Injectables (CME/CE)

Tuesday, August 15, 2017 -- (MedPage Today) -- Jacqueline Nicholas, MD, MPH, on why so many MS patients give up injectables in the long run

Neurology Mastery in Multiple Sclerosis: Managing Pregnancy in MS (CME/CE)

Tuesday, August 15, 2017 -- (MedPage Today) -- Maria Houtchens, MD, of Brigham & Women's Hospital, on relapse rates before, during, and after pregnancy

MRI evidence of acute inflammation in leukocortical lesions of patients with early multiple sclerosis

Monday, August 14, 2017 -- Objective: To identify gadolinium-enhancing lesions affecting the cortex of patients with early multiple sclerosis (MS) and to describe the frequency and evolution of these lesions. Methods: We performed a retrospective, observational, longitudinal analysis of MRI scans collected as part of the Betaseron vs Copaxone in Multiple Sclerosis with Triple-Dose Gadolinium and 3T MRI Endpoints (BECOME) study. Seventy-five patients with early-stage MS were scanned monthly, over a period of 12–24 months, using 3T MRI after administration of triple-dose gadolinium. A total of 1,188 scans were included in the analysis. A total of 139 were selected using an image pipeline algorithm that integrated the image information from cortical gray matter masks and gadolinium-enhancing lesion masks. These scans were evaluated to identify