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Why it's used

Amoxyclav Tablet is used to treat certain infections such as urinary tract infections which include inflammation of the kidney (pyelonephritis), and infection of the wall of the urinary bladder (cystitis), skin and skin structure infections such as serious bacterial skin infection (cellulitis), lower respiratory tract infections which include inflammation of the airways (bronchitis) or infection in the lungs (pneumonia). This medicine is also used to treat acute bacterial inflammation within the nasal passage (acute bacterial sinusitis), acute middle ear infection, gum swelling, and infection from animal bites. It is a prescription medicine. This medicine works by killing the growth of bacteria that cause infection.
When not to use
Amoxyclav Tablet will not work against colds, flu, or other viral infections.
Penicillin-class Antibacterial
Amoxyclav belongs to a class of medicines called Penicillin-class Antibacterial. Penicillin are a group of antibiotics that are used to treat and prevent different type of bacterial infections.

How to use

Follow directions on the product label, information guide, and provided by your doctor before using Amoxyclav. Consume this medicine as per your doctor's instructions.
Amoxyclav is consumed with or without food. Amoxyclav should be taken with food to minimize the digestion difficulties of medicine. Amoxyclav may be taken every 8 hours or 12 hours, according to the prescribed dose and as directed. Do not take two doses in 1 hour.
The typical adult dose of Amoxyclav is 500 mg every 12 hours or 250 mg every 8 hours. The typical dose for children is 45 mg/kg (20.4 mg/lb)/day every 12 hours or 40 mg/kg (18.1 mg/lb)/day every 8 hours (patients aged 12 weeks and older) and 30 mg/kg (13.6 mg/lb)/day divided every 12 hours (neonates and infants aged less than 12 weeks). Amoxyclav is typically used at the same time every day. There are no known habit-forming tendencies with this medicine.
This medicine should be used on an as-needed basis. Amoxyclav should not be used more than 14 days without review. You should continue to use this medicine as directed by the doctor even if you feel well.
Tell your doctor if your condition persists or worsens or if you develop new symptoms. Talk to your doctor if skin rash, severe watery or bloody diarrhea, fever, difficulty in breathing, inflammation of the large intestine, stomach pain, fever, swollen glands in the neck, armpit or groin, swelling of the face or throat, inflammation of blood vessels, and collapse. If you have any kidney disease, the removal of amoxicillin may be delayed as the functioning of the kidney is not completely developed in neonates and young infants. Therefore, dose selection should be modified in these patients. Take necessary precautions while selecting a dose in elderly patients due to increased risk of side-effects.
If you are giving Amoxyclav Tablet to a child, be sure to use a product that is meant for use in children. Before giving this medicine, use the child's weight or age to find the right dose from the leaflet or product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.
If you are using the chewable tablet form of this medicine, make sure you chew the medicine before you swallow it.
To decrease the possibility of side-effects, you might be recommended to use the extended-release form of this medicine by your doctor. The extended-release medicine helps in maintaining a steady level of the medicine in your body for a longer period of time. Do not crush or chew the medicine, unless indicated on the package or by your doctor.
Limit drinking alcohol with Amoxyclav.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Amoxyclav Tablet for symptoms for which it was not prescribed. Do not give Amoxyclav Tablet to others who may have similar symptoms as you. Self-medication can cause harm.
Store Amoxyclav Tablet at 25°C (77° F), away from moisture, and away from sunlight. Keep this medicine away from children and pets.

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How to take Amoxyclav

Your dose and how often you take Amoxyclav will depend on the following factors:
  • age
  • weight
  • patient's health
  • the health of the patient's liver
  • the health of the patient's kidneys
  • medicines recommended by the doctor
  • any other medicines being used
  • herbal supplements in use
  • response to the medicine

Amoxyclav Dosage

Dosage for severe infections of the lower respiratory tract

Adult
  • Recommended: 875 mg every 12 hours or 500 mg every 8 hours (for tablet) and 125 mg/5 ml or 250 mg/5 ml every 8 hours used in place of the 500 mg tablet or 200 mg/5ml suspension or 400 mg/5 ml every 12 hours used in place of the 875 mg tablet (for suspension)
Children (12 weeks (3 months) and older)
  • Recommended: 45 mg/kg/day (20.4 mg/lb/day) every 12 hours or 40 mg/kg/day (18.1 mg/lb/day) every 8 hours

Dosage for middle ear infection (otitis media)

Children (12 weeks (3 months) and older)
  • Recommended: 45 mg/kg/day (20.4 mg/lb/day) every 12 hours or 40 mg/kg/day (18.1 mg/lb/day) every 8 hours

Dosage for less severe infections

Children (12 weeks (3 months) and older)
  • Recommended: 25 mg/kg/day (11.3 mg/lb/day) every 12 hours or 20 mg/kg/day (9 mg/lb/day) every 8 hours

Dosage for bacterial infections

Children (neonates and infants aged less than 12 weeks)
  • Recommended: 30 mg/kg/day (13.6 mg/lb/day) divided every 12 hours (for tablet) or 125 mg/5 ml every 12 hours (for suspension)
Children (12 weeks (3 months) and older)
  • Recommended: 200 mg/5 ml or 400 mg/5 ml every 12 hours and 125 mg/5 ml or 250 mg/5 ml every 8 hours (for suspension)

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 250 mg/125 mg, 500 mg/125 mg, 875 mg/125 mg
Powder for oral suspension
Strength: 125 mg/31.25 mg per 5 ml, 200 mg/28.5 mg per 5 ml, 250 mg/62.5 mg per 5 ml, 400 mg/57 mg per 5 ml
Chewable tablet
Strength: 125 mg/31.25 mg, 200 mg/28.5 mg, 250 mg/62.5 mg, 400 mg/57 mg

Special Instructions

Chewable tablets
Before swallowing the tablet, it should be chewed completely.
Extended-release tablets
Extended-release tablets should be swallowed as a whole. The tablet should not be crushed or chewed.
Oral suspension
The suspension should be prepared at the time of dispensing. The bottle should be tapped until the powder flows freely and for reconstitution add approximately 2/3rd of the total amount of water. After, add the remaining water and shake vigorously. Before using, the suspension bottle should be shaken vigorously. The reconstituted suspension should be stored in the refrigerator and discarded after ten days.

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time of the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed dose.

Overdose

What to do if you overdose on Amoxyclav?
In the case of overdose, Amoxyclav should be discontinued, and symptomatic (treatment according to the symptoms) or supportive therapy should be given. Diuresis, hemodialysis (blood purifying techniques) and adequate fluid intake should be recommended to decrease the harmful effects of Amoxyclav.
Symptoms of an overdose of Amoxyclav
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
  • cloudiness due to crystals in the urine (crystalluria)
  • cramps
  • decreased functioning of the kidney
  • decreased output of urine
  • diarrhea
  • inflammation of the kidney (interstitial nephritis)
  • nausea
  • vomiting
If you think you have overdosed on Amoxyclav Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Amoxyclav

Before you use Amoxyclav, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
Before you use Amoxyclav Tablet, tell your doctor of your medical history including penicillin allergy, allergy to multiple allergens, allergy to cephalosporins, abnormal functioning of the liver, difficulty in the flow of liver secretions (cholestatic jaundice), abnormal functioning of the kidney, inflammation of the colon due to bacteria (Clostridium difficile Associated Diarrhea), mononucleosis (an infectious condition caused by a virus), drug resistance, patients undergone urine testing to detect sugar levels, patients with history of asthma, hay fever and hives, or use of oral contraceptives. A life-threatening allergic reaction is observed in the patient with a history of allergy with penicillin and multiple allergens. An inflammation of the liver (hepatitis) and decrease flow of digestive fluid from liver (cholestatic jaundice) is observed in patients with a history of abnormal liver functioning. Use of this medicine may cause convulsions in patients with abnormal functioning of the kidney or taking a drug in high dose. Use of Amoxyclav in patients with Clostridium difficile associated diarrhea (CDAD) may kill the natural bacteria of intestine which lead to severe diarrhea. Redness and rashes of the skin may be observed in patients with a history of mononucleosis. Using this medicine in improperly diagnosed bacterial infection may lead to the development of resistance in bacteria against the drug.
The use of Amoxyclav Tablet may change blood clotting parameter (prothrombin time). Use of Amoxyclav may increase the prothrombin time. Patients should be monitored carefully.
The use of this medicine may change blood estrogen level. Amoxyclav may decrease the levels of blood estrogen hormone (estriol, estriol-glucuronide, conjugated estrone, and estradiol) during pregnancy.
The use of Amoxyclav Tablet may change liver enzymes (aspartate aminotransferase and alanine aminotransferase). Abnormal functioning of the liver and elevated levels of liver enzymes are observed in patients taking Amoxyclav for a long time.
Amoxyclav Tablet should be used only when required in patients who are pregnant or planning to become pregnant. Amoxyclav should be avoided during pregnancy unless it is necessary during pregnancy. Amoxyclav Tablet should be used while breastfeeding only when required. Amoxyclav may pass into breast milk and can cause diarrhea and fungal infection in the breastfed infant, so Amoxyclav should only be used with precaution or after assessment of risks and benefits of the drug during breastfeeding by the doctor. Consult with your doctor on the use of Amoxyclav Tablet, if you are trying to conceive.
Amoxyclav can make you feel sleepy. Be careful, especially while driving, while using heavy machinery, or when doing any activity that needs you to be completely alert. The consumption of alcohol with Amoxyclav can worsen the sleepiness. Amoxyclav may cause seizures in some people. Hence, you should discuss with your doctor before performing any activities where a loss of consciousness may cause harm to you or others.
Older patients may have a higher incidence of side-effects when using Amoxyclav Tablet. Elderly patients may see an increased risk of inflammation of the liver (hepatitis), difficulty in the flow of bile from liver (cholestatic jaundice), and increased liver enzymes.
Younger patients may have a higher incidence of side-effects with Amoxyclav Tablet. Younger patients may see an increased risk of diarrhea, skin rashes, hives, diaper area rashes, and tooth discoloration.
If this medicine is used for long-term may cause complications like inflammation of the liver (hepatitis), the decrease in bile flow from liver (cholestatic jaundice) and increased levels of liver enzymes.

Amoxyclav Side-effects

The following side-effects may commonly occur when using Amoxyclav Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in older patients on the use of Amoxyclav Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:
  • decrease in flow of bile from liver (cholestatic jaundice)
  • increased liver enzymes (aspartate aminotransferase, alanine aminotransferase)
  • inflammation of the liver (hepatitis)
The following side-effects may commonly occur in children when using Amoxyclav Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:
Rarely, the use of Amoxyclav Tablet may cause the following side-effects:
The following severe side-effects may also occur when using Amoxyclav Tablet:
  • Symptoms: deficiency of red blood cells (hemolytic anemia), low levels of thrombocytes, low levels of the blood cells, low levels of leukocytes low level of granulocytes
    If any of these reactions occur, discontinue the use of Amoxyclav.
  • stomach and intestinal disorders (possible fatal)
    Symptoms: inflammation of the colon due to bacteria (antibiotic-associated colitis), inflammation of both the small intestine and the colon (enterocolitis), inflammation of the stomach lining (gastritis) painful swelling and sores inside the mouth
    Discontinue the use of Amoxyclav, if inflammation of the colon due to bacteria (antibiotic-associated colitis) occur. Appropriate electrolyte and fluid management, antibacterial treatment of inflammation of the colon, protein supplementation, and surgical evaluation should be recommended.
  • kidney disorder
    Symptoms: blood in the urine (hematuria)
    Inform your doctor immediately if you experience any of these side effects.
  • skin and immune system disorders such as allergic reaction (possibly fatal)
    Symptoms: life-threatening skin reaction (Stevens-Johnson Syndrome), life-threatening drug-induced skin reaction (harmful epidermal necrolysis/drug reaction with eosinophilia and systemic symptoms (DRESS)), red skin rash with small pus-containing blisters (bullous exfoliative dermatitis), blisters and red, scaly rash with bumps under the skin (exanthemous pustulosis), flu-like symptoms, skin allergic reaction caused by infection (erythema multiforme), allergic reaction to an injection of foreign protein, swelling of the face or throat, inflammation of blood vessels (allergic vasculitis) life-threatening allergic reaction (anaphylactic reactions/anaphylaxis)
    If an allergic reaction occurs, discontinue the use of Amoxyclav, and appropriate therapy should be recommended.
  • central nervous system disorder
    Symptoms: convulsions, inflammation of the brain and spinal cord membranes (aseptic meningitis), agitation, anxiety confusion
    Inform your doctor immediately if you experience any of these side effects.
  • liver disorders (possible fatal)
    Symptoms: inflammation of the liver (hepatitis), difficulty in the flow of liver secretions (cholestatic jaundice), increased aspartate aminotransferase increased alanine aminotransferase
    Inform your doctor immediately if you experience any of these side effects.
Your doctor has prescribed Amoxyclav Tablet because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Amoxyclav Tablet.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Excessive growth of non-sensitive bacteria (overgrowth of non-susceptible organisms)

Patients taking Amoxyclav are at an increased risk. Prolong use of Amoxyclav treatment may develop excessive growth of non-sensitive bacteria against medicines.

Patients taking allopurinol

Such patients are at an increased risk when using Amoxyclav. These patients may develop an allergic skin reaction.

Patients with amoxicillin sensitive bacterial (amoxicillin-susceptible organism) infection

Patients with amoxicillin-susceptible organism are at increased risk when using Amoxyclav. Amoxyclav may cause an infection in such patients. Changing Amoxyclav therapy to only amoxicillin therapy should be recommended after proper clinical guidance.

Abnormal functioning of the kidney

Patients with abnormal functioning of the kidney or taking higher doses of Amoxyclav are at an increased risk when using Amoxyclav. Use of Amoxyclav in these patients may cause convulsions. Dose adjustment is recommended in such patients.

Development of drug-resistant bacteria

Using Amoxyclav in the improper diagnosis of bacterial infection may cause the development of resistance in bacteria for the drug.

Microbial overgrowth

The patients who are using Amoxyclav are at an increased risk of occurrence of superinfections caused by bacterial or fungal pathogens. If superinfection occurs, discontinue the use of Amoxyclav.

Patients with mononucleosis (an infectious condition caused by virus)

Such patients are at an increased risk when using Amoxyclav. Amoxyclav cause redness of the skin (erythematous skin rash) in patients with mononucleosis. Such patients should not use this medicine.

Clostridium difficile associated diarrhea

The patients using antibacterial drugs are at increased risk while using this medicine. The use of Amoxyclav may cause mild diarrhea to possibly fatal colitis. Antibacterial agents alter the organisms present in the colon causing overgrowth of the Clostridium difficile bacteria. If Clostridium difficile associated diarrhea (CDAD) occurs discontinue the use of Amoxyclav. The suitable treatment for treatment of this kind of diarrhea includes an appropriate fluid and electrolyte management, protein supplementation, antibacterial drug treatment, and surgical evaluation as clinically indicated.

Abnormal functioning of the liver

Such patients are at an increased risk when using this medicine. These patients may experience conditions such as abnormal functioning of the liver, inflammation of the liver (hepatitis), decrease in bile flow from liver (cholestatic jaundice) and fatal conditions due to liver failure. Precaution in dose adjustment and regular monitoring of liver function is recommended in patients with abnormal functioning of the liver.

Allergic to Amoxyclav

Patients with a history of allergic reactions to penicillins, cephalosporins, allergens or receiving beta-lactam antibacterials are at an increased risk when using Amoxyclav. Such patients may experience life-threatening allergic reactions (anaphylactic) reactions. Before starting the treatment with Amoxyclav, careful analysis is required regarding previous allergic reactions to penicillins, cephalosporins, or other allergens. If an allergic reaction occurs, discontinue the use of Amoxyclav.

Patients with blisters and red, scaly rash with bumps under the skin (acute generalized exanthemous pustulosis)

The patients with these skin conditions are at increased risk when using this medicine. Using Amoxyclav may cause fever and blisters with red, scaly rash and bumps under the skin (feverish generalized erythema) along with pus-containing blisters (pustula) in patients with acute generalized exanthemous pustulosis. Patients should stop or avoid taking Amoxyclav on the occurrence of feverish generalized erythema with pustules.

Use of anticoagulants with Amoxyclav

Patients taking anticoagulants with Amoxyclav are at increased risk when using this medicine. These patients may experience increased bleeding time (prothrombin time). Careful monitoring and dose adjustment of anticoagulants are recommended in patients using Amoxyclav.

Patients with reduced urination

Patients with reduced urination are at increased risk when using Amoxyclav. Using Amoxyclav in patients with reduced urine output may cause cloudiness due to crystals in the urine (crystalluria) when taken parenterally. Appropriate fluid intake and excretion of urine are recommended in patients. A regular checkup is necessary for patients with bladder catheters.

Urine glucose test

Using Amoxyclav may cause false positive results during a urine glucose test. Use enzymatic glucose oxidase methods for testing of the presence of glucose in urine.

False positive Coombs test

Using Amoxyclav may cause a non-specific binding of antibody and protein (IgG and albumin respectively) due to the presence of clavulanic acid which may result in a false positive Coombs test.

Interactions with Amoxyclav

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Amoxyclav Tablet interacts with allopurinol, which is used to treat redness and tenderness in the joints (gout). Patients using amoxicillin with allopurinol may experience the increased occurrence of rashes as compared to patients taking amoxicillin alone. It is unknown whether the increased incidence of rashes is due to the combined usage of amoxicillin with allopurinol or due to increased levels of uric acid (hyperuricemia) in patients.
There may be an interaction of Amoxyclav with oral anticoagulants (acenocoumarol and warfarin), which are used to prevent blood clotting. The use of amoxicillin in combination with oral anticoagulants may abnormally increase the bleeding time in patients. Careful monitoring of blood clotting parameter, with the use or withdrawal of amoxicillin and dose adjustment of oral anticoagulants, is recommended in patients using anticoagulants with Amoxyclav.
Amoxyclav Tablet may interact with probenecid, which is used to treat redness and tenderness in the joints (gout). Probenecid decreases the secretion of amoxicillin in the kidney. The use of Amoxyclav with probenecid may increase the level of amoxicillin in the blood. Patients should not use probenecid with Amoxyclav.
Your doctor's guidelines may need to be followed while taking this medicine along with false-positive reactions. Patients using Amoxyclav or amoxicillin alone during testing of glucose in urine using Benedict's solution, Fehling's solution or testing kit may see an increased risk of false positive reactions. Enzymatic glucose oxidase reactions based glucose test should be recommended in such patients.
Special instructions need to be followed while taking this medicine along with oral contraceptives, which are used to prevent unwanted pregnancy. The use of Amoxyclav may affect the natural bacteria of the digestive tract which may lead to decreased hormone reabsorption and reduced the effectiveness of oral contraceptives.
There may be an interaction of Amoxyclav with mycophenolate mofetil, which is used to prevent rejection in organ transplantation. The use of Amoxyclav with mycophenolate mofetil may decrease the level of mycophenolate mofetil in the blood. Doctors should monitor the patients carefully as soon as possible after antibiotic treatment and during the combination therapy.
Amoxyclav Tablet may interact with methotrexate, which is used to treat cancer. Use of penicillins may decrease the excretion of methotrexate which may lead to increased harmful effects.
This page does not contain all the possible interactions of Amoxyclav Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Amoxyclav is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.

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