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Why it's used

Ampilox Capsule is used to treat certain infections including, respiratory infections such as pneumonia with inflammation in the bronchi and worsen severe inflammation of the bronchial tubes lining. It is also used to treat problems during childbirth such as fever caused by a uterine infection during delivery. Ampilox may also treat other infections such as blood and bone infections, ear, nose and throat infections. This medicine contains ampicillin and cloxacillin, both damage the bacteria by acting on the bacterial cell wall formation. Ampilox is also used to prevent & treat bacterial infections in the premature or newborn child, and to treat wound and respiratory system infections after an operation.
Antibacterials
Ampilox is a prescription medicine that belongs to a class of medicines called Antibacterials. Antibacterials, also known as Antibiotics, are widely used in the treatment and prevention of diseases caused by bacteria. It destroys or slows down the growth of bacteria.

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How to use

Read the medicine guide provided by your pharmacist, your doctor, or the medicine company. If you have any questions related to Ampilox, ask your doctor or pharmacist. Use Ampilox Capsule as per the instructions provided by your doctor.
Ampilox is used 0.5-1 hour before food. The oral absorption of Ampilox may get decreased due to the presence of food in the stomach.

Typical Dosage

The typical dose of Ampilox for adults is 1000-2000 mg every 6 hours orally or 500-1000 mg injection into the muscle every 4-6 hours. The usual dose for children is 5-10 ml suspension every 6 hours orally or 250 mg injection every 8 hours in children aged 2-12 years and 0.6 ml (90 mg) suspension 0.5-1 hour before feeding after every 4 hours in newborn babies to 2 years aged children. This medicine is not known to be addictive or habit-forming.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.

Talk to Your Doctor

Discuss with your doctor if your condition persists or worsens or if you develop new symptoms. Discuss with your doctor if diarrhea, and abdominal cramps. If you have any kidney disease, the starting dose should be normal according to the indication. Maintenance dose for patients with 10-50 ml/minute creatinine clearance should be given three times daily 500 mg orally, up to 1000 mg injection into muscle or veins. Patients with creatinine clearance below 10 ml/minute, maintenance dose should be given twice or once daily as a normal dose. If you have issues with the health of your liver, a low dose should be taken based on the severity of the condition.

Use in Children

If you are giving Ampilox Capsule to a child, be sure to use a product that is for use in children. Use the child's weight or age to find the right dose from the product package or medicine label. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Lab Tests

Your doctor may request that specific lab tests be performed before you start using Ampilox Capsule. Your doctor may ask you to undergo Antibiotic Susceptibility | Culture Test test. Antibiotic susceptibility and culture test is required to help in selecting an appropriate antibacterial drug for the treatment.
Medicines may be recommended for uses other than those listed in the medicine guide. You should not use Ampilox Capsule for conditions or symptoms for which it was not prescribed. Do not give Ampilox Capsule to other people, even if they have the same conditions or symptoms that you have. The use of this medicine without the advice of a doctor may cause harm.

Storage

Follow storage instructions on the product package if available. Store Ampilox Capsule below 25°C (77°F), the suspension should be used within 7 days of dispensing. Oral drops for newborn babies should be kept in the refrigerator, do not freeze and should be used within 5 days of dispensing, and away from moisture. Store this medicine away from children and pets.

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How to take Ampilox

Your dose and how often you take Ampilox will depend on the following factors:
  • age
  • patient's health
  • the health of the patient's liver
  • the health of the patient's kidneys

Ampilox Dosage

Dosage for infections

Adult
  • Recommended: 1000-2000 mg every 6 hours orally or 500-1000 mg injection into the muscle every 4-6 hours
Children (aged 2-12 years)
  • Recommended: 5-10 ml suspension every 6 hours orally or 250 mg injection every 8 hours
Children (newborns upto 2 years)
  • Recommended: 0.6 ml (90 mg) suspension 0.5-1 hour before feeding after every 4 hours

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Capsules
Strength: 250 mg ampicillin and 250 mg cloxacillin
Oral Suspension
Strength: 125 mg ampicillin and 125 mg cloxacillin
Oral Drops
Strength: 60 mg ampicillin and 30 mg cloxacillin/0.6 ml

Special Instructions

Creatinine clearance between 10-50 ml/minute
The starting dose should be normal according to the indication. Maintenance dose for patients should be given three times daily 500 mg orally or up to 1000 mg injection into muscle or veins.
Creatinine clearance below 10 ml/minute
The starting dose should be normal according to the indication.
Blood purifying technique (dialysis)
Patients on blood purifying technique (dialysis), a normal dose of 500 mg orally or upto 1000 mg injection into muscle or veins is to be given after dialysis.
Liver dysfunction
A low dose should be taken in patients with liver dysfunction based on the severity of the condition.

Overdose

What to do if you overdose on Ampilox?
In case of overdose, the treatment should be provided according to the symptoms.
Symptoms of an overdose of Ampilox
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Ampilox Capsule, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Ampilox

Before you use Ampilox, tell your doctor of your medical and health history including the following:
  • a viral infection (mononucleosis)
  • allergic to beta-lactam antibiotics
  • blood cancer (leukemia)
Patients suffering from these conditions are at an increased risk for the occurrence of skin rash when using ampicillin. As a result, the use of ampicillin should be avoided in such patients.
Before you use Ampilox Capsule, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic any of the following substances: penicillins, or cephalosporins.

Seizures

Ampilox Capsule may cause rarely seizures in some people. If you perform any activities where a loss of consciousness may cause harm to you (or others), you should discuss with your doctor.

Use in Pregnancy

It is not known if this medicine is safe for use in women who are pregnant or planning to become pregnant. Consult with your doctor before you use Ampilox during pregnancy or if you plan on becoming pregnant. There are no well-controlled studies of Ampilox available for pregnant women.

Use while Breastfeeding

It is not known if this medicine is safe for use in women who breastfeed. Consult with your doctor before you use Ampilox Capsule while breastfeeding. There are no well-controlled studies of Ampilox available for breastfeeding women.

Side-effects in Children

Ampilox may cause an increased risk of side-effects in children. Children using this medicine may see an increased risk of jaundice.

Long-term Use

Long term use of Ampilox may cause overgrowth of resistant organisms.

What precautions should be taken during Pregnancy and Nursing, and administering Ampilox to Children or the Older Adults?

Pregnant Women

Unknown
Warning: There are no well-controlled studies of Ampilox in pregnant women.

Breastfeeding

Unknown
Warning: There are no well-controlled studies of Ampilox in breastfeeding women.

Younger Adults Population

Precaution
Warning: Ampilox may cause jaundice in newborn babies. Cloxacillin should be used with caution in the treatment of babies with jaundice.

Ampilox Side-effects

The following side-effects may commonly occur when using Ampilox Capsule. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in children when using Ampilox Capsule. Discuss with your doctor if any of these side-effects last for a long time or are severe:
Rarely, the use of Ampilox Capsule may cause the following side-effects:
  • involuntary jerking of the muscle
  • moderate and temporary increase in enzymes (transaminases)
  • purple discolored spots on the skin
The following severe side-effects may also occur when using Ampilox Capsule:
  • Symptoms: anemia due to the breakdown of red blood cells, low white blood cell count, low platelet level low neutrophil cell count
  • Nervous system disorders
    Symptoms: convulsions
  • Stomach and intestinal disorders
    Symptoms: diarrhea, vomiting, inflammation of the colon (pseudomembranous colitis) bacterial infection in the large intestine (hemorrhagic colitis)
  • Liver disorders
    Symptoms: hepatitis jaundice with a decreased flow of bile (cholestatic jaundice)
  • Kidney disorders
    Symptoms: swelling in the spaces between kidney tubes (interstitial nephritis)
    If this happens, stop using this medicine.
  • Skin disorders
    Symptoms: skin rash, severe allergic reactions (erythema multiforme, Stevens-Johnson syndrome) drug-induced severe allergic reaction
    If this happens, stop using this medicine.
Your doctor has prescribed this medicine because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious cases of side-effects. This page does not contain a complete list of all possible side-effects.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Ampilox by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:
  • myoclonus
  • purpura
  • transient and moderate increase in transaminases

Severe Side-effects

Following are the severe side-effects of this medicine:

Side-effects in Children

Following are the side-effects of this medicine in young patients:

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
  • drug induced severe allergic reaction (toxic epidermal necrolysis)
  • severe allergic reactions (erythema multiforme, Stevens-Johnson syndrome)
  • skin rash
  • swelling in the spaces between kidney tubes
If this happens, stop using this medicine.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Sodium Content

Patients with a sodium-restricted diet are at an increased risk. In these patients, the sodium content of this medicine must be involved in their daily sodium diet allowance.

Jaundice

Newborn babies having jaundice are at high risk. Cloxacillin may relocate bilirubin from its protein binding sites. Ampilox suspension and neonatal oral suspension containing sodium benzoate may cause irritation to eyes, skin and mucous membrane. Cloxacillin should be used with caution in the treatment of jaundice in newborn babies.

Kidney Problem

The dose of Ampilox should be adjusted in patients having a kidney problem.

Stomach Problems

Patients using antibiotics are at an increased risk. These patients may suffer from mild to life-threatening swelling of the large intestine. It is necessary to observe the swelling of the large intestine in patients who suffer from diarrhea while using or after the use of an antibiotic. Use of Ampilox should be stopped and the patient is examined further if a long term or significant diarrhea or stomach cramps are observed.

Long-Term Use

Long term use of Ampilox may lead to overgrowth of resistant organisms.

Infections

Skin rash has occurred with a viral infection (mononucleosis) or severe blood cancer after the use of ampicillin. If these conditions may be suspected, avoid the use of ampicillin in such patients.

Allergic Reactions

Patients having allergy from beta-lactam are at high risk. It is reported that patients taking beta-lactam antibiotics may suffer from severe and irregular fatal allergic reactions. A severe allergic reaction is more likely to occur when penicillin is taken through injection as compared to oral therapy. The use of Ampilox should be stopped and start a suitable alternative treatment if an allergic reaction occurs. Treat the side effects according to the symptoms.

Penicillins and Cephalosporins Use

Patients using penicillin with cephalosporins are at high risk. Caution is advised in such patients.

Prior Allergic Reaction

Careful monitoring should be conducted regarding prior allergic reaction to beta-lactam before starting Ampilox treatment.

Oral Drops to Babies

Babies whose mothers are allergic to penicillin are at an increased risk while using Ampilox neonatal oral drops. Caution should be advised in such patients.

Aminoglycoside

Patients using aminoglycoside and Ampilox together are at an increased risk. If these medicines are mixed in the same container, the loss of activity due to an infusion solution may occur. In such cases, these medicines should not be mixed in one container.

Interactions with Ampilox

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Ampilox Capsule. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Sulphonamides and Nonsteroidal Anti-Inflammatory Drugs

Ampilox Capsule interacts with sulphonamides and acetylsalicylic acid, which are used to treat bacterial infections and fever/pain respectively. Acetylsalicylic acid and sulphonamides prevent the blood protein binding of cloxacillin, and this may result in enhanced levels of cloxacillin in the blood.

Birth Controlling Pills

There may be an interaction of Ampilox with birth control pills, which are used to prevent pregnancy. Ampilox may affect the bacteria present in the stomach (gut flora) which leads to reduce the reabsorption of hormone (oestrogen) and decrease the effect of combined birth controlling pills.

Uricosuric Agents

Ampilox Capsule may interact with probenecid, which is used to prevent gout. Probenecid lowers the elimination of Ampilox by the kidneys. Use of probenecid with Ampilox may lead to enhanced and prolonged blood levels of Ampilox.

Xanthine Oxidase Inhibitors

Your doctor's guidelines may need to be followed while taking this medicine along with allopurinol, which is used to treat gout. Use of allopurinol with Ampilox may increase the possibilities of skin allergic reactions.

Antibiotics

Special instructions need to be followed while taking this medicine along with bacteriostatic drugs, which are used to prevent bacterial growth. Drugs that prevent the growth of bacteria may interfere with the bacterial damaging effect of Ampilox.

Interactions of Ampilox by Severity

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Ampilox be not used?

Allergy

Ampilox should not use in patients with a history of allergy to beta-lactam antibiotics such as cephalosporins, penicillins or any other ingredient of the medicine. Patients using Ampilox may get suffer from allergic reactions.

Use in Eyes

Ampilox should not be used for eyes.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Ampilox is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Ampilox Capsule .
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