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Autoimmune diseases are tough to diagnose in their early stages.

Early Detection of Lupus Disease Possible Now

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The researchers at Valencia Polytechnic University, Spain have developed the most sensitive system to detect autoimmune diseases.

The study was published on February 1st, 2019 on the official website of RUVID Association. Valencia's Polytechnic University, Spain is one of the members of this association.

A system has been developed by the researchers, which is 2,000 times more sensitive than the tests done by the doctors. This technique enables doctors to spot the autoimmune diseases in patients.

This system only requires microliters of saliva or blood to function. It takes just an hour’s time to detect the disease.

The autoimmune diseases like rheumatoid arthritis or lupus erythematosus are considered tough to diagnose in their early stages. In lupus disease, specific antibodies are found in the nucleus of cells. These antibodies include the anti-Ro/SSA. Such antibodies are located in the blood.

Angel Maquieira, one of the researchers of Valencia’s Polytechnic University (UPV) said, “Each autoimmune disease creates its own anti-Ro/SSA antibodies with a specific fingerprint, which is differentiated by our biosensor.”

Maquieira further added, “Furthermore, it quantifies very low amounts of anti-Ro/SSA antibodies (the equivalent of being 2,000 times more sensitive than current diagnostic tests), which makes it possible to assess very early on the symptoms that the patient shows.”

According to the doctor José Andrés Román, head of the Clinical Department of Rheumatological Diseases of the Hospital La Fe, “The results obtained from comparing this technique to assess symptoms shown by the patients and their activity, in more than 150 patients with lupus and a group of healthy people, has confirmed the high sensitivity of this new technique.”

The current tests are not helpful as much as the newly developed sensitive system. The old system limits the capacity to expose the antibodies. Such antibodies are in very low amounts that occur in the initial stages of the disease.

The researchers have tackled the shortcoming of the old techniques by developing a highly sensitive biosensor at the laboratory scale. This system assists doctors in the quick recognition of autoantibodies in early stages of the disease.

The researchers also explained that the tests that are used by the doctors to spot the presence of immunologic bodies use the ELISA technique. These tests trace the autoantibodies with the help of the ELISA technique.

One of the professors at Valencia University has explained that the new biosensor has a new pattern in the systems. Using the new system doctors can detect the extent of the antibodies as well as its interaction.

The diagnosis can be done with the “fingerprints” that are particular to each disease and issue the prognosis. The new system is a 2-in-1 that does diagnosis and prognosis.

The researchers have got a patent of their biosensor by the UPV, UV and La Fe Hospital. This biosensor can now be used for clinical practice.

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