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The men who were treated with the anti-hormonal medicines were found to be 1.8 times more likely to suffer from depression.

Hormonal Treatment Triggers Depression in Men with Prostate Cancer

By Damini  •  

The researchers have found that men who receive anti-hormonal treatment after getting their prostate removed are more likely to suffer from depression.

This information was published by European Association of Urology on March 18th, 2019.

The men who go through this treatment after getting their prostate removed have 80 percent more chances to face depression than the untreated men. The researchers have started monitoring the patients for post-surgical depression. This is suggested for the patients who have received the androgen deprivation therapy.

The doctors have said that many men diagnosed with a cancer face depression. The rates of suicide are also rising excessively in men with urological cancers. Now researchers have also proved the increased tendency of depression in men who receive anti-hormonal treatment after radical prostatectomy.

During the study, the researchers had examined the medical records of 5,570 men from the Danish Prostate Cancer Registry. It was found that 773 of these examined men were treated with the depression after their surgery of prostate cancer.

The men who were treated with the anti-hormonal medicines were found to be 1.8 times more likely to suffer from depression. The link between the radiotherapy after radical prostatectomy and depression was also checked by the researchers but the results were unconvincing.

One of the researchers of the study has said that this treatment stops the development of androgen hormones in men, like testosterone. It is also known that low testosterone can affect the well-being of men.

The lead researcher of the study, Dr. Anne Sofie Friberg from the Rigshospitalet in Copenhagen said, "The antihormonal treatment is given to control the growth of tumor cells. Unfortunately, we have found that it is also associated with depression."

Mr. Erik Briers, patient member of the EAU guidelines committee on prostate cancer said, "This study is very relevant from the patient's point of view; it again shows the importance of the holistic treatment of prostate cancer patients and in this treatment the importance of including psycho-oncology and socio-psychology professionals."

It has been found that in comparison to the men who do not have prostate cancer, the patients who are treated with prostatectomy shows an increased risk of depression. After the surgery, erectile dysfunction and urinary incontinence are common symptoms in them. Also, the decrease in testosterone levels can directly affect the mood controlling areas of the men’s brain.

As one-fourth of the men undergoes radical prostatectomy, they may be offered hormonal treatment. Once the hormonal treatment is introduced, these men will have a higher risk of depression. Failing surgery could be one of the consequences that can directly cause hormonal manipulation.

The study also shows that prostate cancer treatment can cause other issues in men. This demands a multi-disciplinary approach to treat prostate cancer. There is a need for following evidence-based guidelines so that the patient gets comprehensive care during the treatment.

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