When two or more
medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a
Drug Interaction.
Klion Tablet may interact with
disulfiram, which is used for the treatment of alcoholism. The patients who use Klion in combination with disulfiram may develop mental problems (psychotic reactions). The patients who have taken disulfiram within the last two weeks should not take Klion.
There may be an interaction of
Klion with
alcoholic beverages, which is an
alcoholic drink containing
ethanol, known as alcohol. The patients undergoing treatment with Klion may experience
cramps in stomach,
nausea, vomiting,
headache, and flushing if they consume alcohol or substances containing propylene
glycol during or after treatment. Patients who are on treatment with Klion should stop consumption of alcohol or products that contain propylene glycol during and after three days of therapy with Klion.
Klion Tablet interacts with
warfarin and other oral
anticoagulants, which are used to prevent blood clots. The patients who use Klion in combination with anticoagulants such as warfarin may experience an increased anticoagulant effect of warfarin and other oral anticoagulants, which may further prolong the blood clotting time. In such patients, the time that blood takes to clot (prothrombin time and international normalized ratio) should be carefully monitored.
Special instructions need to be followed while taking this medicine along with
lithium, which is used to treat a major
depressive disorder. The patients who are on high dose levels of
lithium and who undergo short-term treatment with Klion have been associated with increased levels of lithium in the blood. In some cases, lithium
poisoning may occur due to high levels of lithium. The levels of lithium and
creatinine in the blood should be monitored after certain days of beginning treatment with Klion to recognize any increase that may lead to clinical symptoms of damage due to lithium accumulation.
Your doctor's guidelines may need to be followed while taking this medicine along with
Busulfan, which is used in the treatment of certain types of
cancers. The patients who use Klion in combination with
busulfan may experience an increase in the levels of busulfan in the blood, which may result in an increased risk of harmful effects of busulfan due to its accumulation. Patients who are on treatment with Klion should not be given busulfan if the benefit by busulfan is less than the risk. If there is no other treatment available, the levels of busulfan in the blood should be monitored routinely and its dose should be adjusted properly.
Klion Tablet may interact with drugs that prevent CYP450
enzymes such as
cimetidine, which is used to treat certain types of
ulcers. The patients who use Klion in combination with the drugs that prevent CYP450
enzymes such as cimetidine may increase the level and decrease the clearance of Klion from the blood.
There may be an interaction of
Klion with drugs that induce CYP450
enzymes such as
phenytoin or
phenobarbital, which is used for the
prevention of tonic-clonic
seizures. The patients who use Klion in combination with the drugs that induce microsomal
liver enzymes such as phenytoin or phenobarbital may enhance the elimination of Klion. It results in reduced levels of Klion in the blood and disrupted clearance of phenytoin has also been reported.
Klion Tablet interacts with drug or laboratory tests. The patients who use Klion may
interfere with certain types of tests of blood chemistry values such as
aspartate aminotransferase,
lactate dehydrogenase,
alanine aminotransferase,
triglycerides, and
glucose hexokinase and the values of zero have been observed.
Special instructions need to be followed while taking this medicine along with
ciclosporin, which is used as an immunosuppressant. The patients who use Klion in combination with ciclosporin may experience an increase in ciclosporin levels in the blood. Patients who are on treatment with both Klion and ciclosporin should closely monitor the levels of ciclosporin and
creatinine in the blood.
Your doctor's guidelines may need to be followed while taking this medicine along with 5
fluorouracil, which is used in the treatment of
cancer. When Klion is given along with 5
fluorouracil, the clearance of 5 fluorouracil is decreased and the accumulation of 5 fluorouracil can result in harmful effects.
This page does not contain all the possible interactions of Klion Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any
medicines without the approval of your doctor.