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Duke Criteria for Infective Endocarditis

Microrganisms presence in vegetation
Demonstrated by culture or histologic examination of a vegetation, a vegetation that has embolized, or an intracardiac abscess specimen
No 0
Yes 1.1
Pathological lesions
Vegetation or intracardiac abscess confirmed by histologic examination showing active endocarditis.
No 0
Yes 2.1
Blood cultures positive for endocarditis
Typical microorganisms consistent with IE from 2 separate blood cultures, microorganisms consistent with IE from persistently positive blood cultures, single positive blood culture for Coxiella burnetii or antiphase I IgG antibody titer >1:800.
No 0
Yes 4
Evidence for Endocardial involvement
Echocardiogram positive for IE, abscess, new partial dehiscence of prosthetic valve, new valvular regurgitation. Note: Worsening or changing of pre-existing murmur NOT sufficient.
No 0
Yes 8
Predisposing heart condition or injection drug use
No 0
Yes 10
No 0
Yes 20
Vascular Phenomenon
Major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, and Janeway’s lesions.
No 0
Yes 100
Immunologic Phenomenon
Glomerulonephritis, Osler’s nodes, Roth’s spots, and rheumatoid factor
No 0
Yes 200
Microbiological Evidence
Positive blood culture but does not meet a major criterion as noted above or serological evidence of active infection with organism consistent with IE.
No 0
Yes 1000


Result Interpretation

Ranges Ranges

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