Demonstrated by culture or histologic examination of a vegetation, a vegetation that has embolized, or an intracardiac abscess specimen
Vegetation or intracardiac abscess confirmed by histologic examination showing active endocarditis.
Blood cultures positive for endocarditis
Typical microorganisms consistent with IE from 2 separate blood cultures, microorganisms consistent with IE from persistently positive blood cultures, single positive blood culture for Coxiella burnetii or antiphase I IgG antibody titer >1:800.
Evidence for Endocardial involvement
Echocardiogram positive for IE, abscess, new partial dehiscence of prosthetic valve, new valvular regurgitation. Note: Worsening or changing of pre-existing murmur NOT sufficient.
Predisposing heart condition or injection drug use
Major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, and Janeway’s lesions.
Glomerulonephritis, Osler’s nodes, Roth’s spots, and rheumatoid factor
Positive blood culture but does not meet a major criterion as noted above or serological evidence of active infection with organism consistent with IE.