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Dutch Criteria for Familial Hypercholesterolemia (FH)

Entry Criterion
Patient has elevated cholesterol, family history of FH, and/or family history of premature cardiac death
No 0
Yes 0
Family history of first-degree relative with premature coronary and/or vascular disease
Male relative <55 years, female relative <60 years
No 0
Yes 1
Family history of first-degree relative with known LDL >95th percentile for age and sex
No 0
Yes 1
Family history of first-degree relative with tendon xanthomata and/or arcus cornealis
No 0
Yes 2
Family history of children <18 years with known LDL >95th percentile for age and sex
No 0
Yes 2
Clinical history in patients with premature coronary artery disease
No 0
Yes 2
Clinical history in patients with premature cerebral or peripheral vascular disease
No 0
Yes 1
Tendon xanthomata on physical examination
No 0
Yes 6
Arcus cornealis at age <45 years on physical examination
No 0
Yes 4
Cholesterol Level
LDL-C ≥8.5 (330) 8
LDL-C 6.5 - 8.4 (250 - 329) 5
LDL-C 5.0 - 6.4 (190 - 249) 3
LDL-C 4.0 - 4.9 (155 - 189) 1
DNA Analysis
Functional mutation of LDLR, apoB or PCSK9 gene
No 0
Yes 8
Result:

Background

Result Interpretation

Ranges Ranges