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Gleason Score for Prostate Cancer

Primary grade
The dominant pattern of the tumor (>50% of total pattern seen)
Closely resembles normal prostate. Glands are small, well-formed, closely packed. 1
Increased stroma with well-formed glands, but larger with more tissue between them. 2
Recognizable glands, but cells are darker. Some cells have left the glands and are beginning to invade the surrounding tissue or have an infiltrative pattern. 3
Few recognizable glands. Many cells invading the surrounding tissue in clumps. 4
Few or no recognizable glands. Often sheets of cells throughout the surrounding tissue. 5
Secondary grade
The highest grade pattern seen after the primary pattern
Closely resembles normal prostate. Glands are small, well-formed, closely packed. 1
Increased stroma with well-formed glands, but larger with more tissue between them. 2
Recognizable glands, but cells are darker. Some cells have left the glands and are beginning to invade the surrounding tissue or have an infiltrative pattern. 3
Few recognizable glands. Many cells invading the surrounding tissue in clumps. 4
Few or no recognizable glands. Often sheets of cells throughout the surrounding tissue. 5
Tertiary grade
Small component of a third (generally more aggressive) pattern
Closely resembles normal prostate. Glands are small, well-formed, closely packed. 1
Increased stroma with well-formed glands, but larger with more tissue between them. 2
Recognizable glands, but cells are darker. Some cells have left the glands and are beginning to invade the surrounding tissue or have an infiltrative pattern. 3
Few recognizable glands. Many cells invading the surrounding tissue in clumps. 4
Few or no recognizable glands. Often sheets of cells throughout the surrounding tissue. 5
Result:

Background

Result Interpretation

Ranges Ranges