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Why it's used

Clam Capsule is a prescription medicine that is used to treat certain infections including, respiratory infections such as pneumonia with inflammation in the bronchi and worsen severe inflammation of the bronchial tubes lining. It is also used to treat problems during childbirth such as fever caused by a uterine infection during delivery. Clam may also treat other infections such as blood and bone infections, ear, nose and throat infections. This medicine contains ampicillin and cloxacillin, both damage the bacteria by acting on the bacterial cell wall formation. Clam Capsule is also used to prevent & treat bacterial infections in the premature or newborn child, and to treat wound and respiratory system infections after an operation.
Clam belongs to the Antibacterials class of medicines. Antibacterials, also known as Antibiotics, are widely used in the treatment and prevention of diseases caused by bacteria. It destroys or slows down the growth of bacteria.

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How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Clam Capsule. If you have any questions related to this medicine, ask your doctor or pharmacist. Use this medicine as recommended by your doctor.
Clam Capsule is used 0.5-1 hour before food. The oral absorption of Clam may get decreased due to the presence of food in the stomach.

Typical Dosage

The typical dose of Clam is 1000-2000 mg every 6 hours orally or 500-1000 mg injection into the muscle every 4-6 hours. The usual dose for children is 5-10 ml suspension every 6 hours orally or 250 mg injection every 8 hours in children aged 2-12 years and 0.6 ml (90 mg) suspension 0.5-1 hour before feeding after every 4 hours in newborn babies to 2 years aged children. This medicine is not known to be habit-forming.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.

Talk to Your Doctor

Talk to your doctor if your condition persists or worsens or if you develop new symptoms. Tell your doctor if diarrhea, and abdominal cramps. If you have any kidney disease, the starting dose should be normal according to the indication. Maintenance dose for patients with 10-50 ml/minute creatinine clearance should be given three times daily 500 mg orally, up to 1000 mg injection into muscle or veins. Patients with creatinine clearance below 10 ml/minute, maintenance dose should be given twice or once daily as a normal dose. If you have issues with the health of your liver, a low dose should be taken based on the severity of the condition.

Use in Children

If you are giving Clam Capsule to a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child's weight or age to find the right dose from the product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Lab Tests

Your doctor may request that specific lab tests be performed before you start using Clam Capsule. You may need to have Antibiotic Susceptibility | Culture Test test. Antibiotic susceptibility and culture test is required to help in selecting an appropriate antibacterial drug for the treatment.


You should store Clam Capsule below 25°C (77°F), the suspension should be used within 7 days of dispensing. Oral drops for newborn babies should be kept in the refrigerator, do not freeze and should be used within 5 days of dispensing, and away from moisture. Store the medicine away from the reach of children and pets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Clam Capsule for conditions for which it was not prescribed. Do not give Clam Capsule to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

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How to take Clam

The dose and frequency of using Clam will depend on the following factors:
  • age of the patient
  • patient's health
  • the health of the patient's liver
  • the health of the patient's kidneys

Clam Dosage

Dosage for infections

  • Recommended: 1000-2000 mg every 6 hours orally or 500-1000 mg injection into the muscle every 4-6 hours
Children (aged 2-12 years)
  • Recommended: 5-10 ml suspension every 6 hours orally or 250 mg injection every 8 hours
Children (newborns upto 2 years)
  • Recommended: 0.6 ml (90 mg) suspension 0.5-1 hour before feeding after every 4 hours

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.


Strength: 250 mg ampicillin and 250 mg cloxacillin
Oral Suspension
Strength: 125 mg ampicillin and 125 mg cloxacillin
Oral Drops
Strength: 60 mg ampicillin and 30 mg cloxacillin/0.6 ml

Special Instructions

Creatinine clearance between 10-50 ml/minute
The starting dose should be normal according to the indication. Maintenance dose for patients should be given three times daily 500 mg orally or up to 1000 mg injection into muscle or veins.
Creatinine clearance below 10 ml/minute
The starting dose should be normal according to the indication.
Blood purifying technique (dialysis)
Patients on blood purifying technique (dialysis), a normal dose of 500 mg orally or upto 1000 mg injection into muscle or veins is to be given after dialysis.
Liver dysfunction
A low dose should be taken in patients with liver dysfunction based on the severity of the condition.


What to do if you overdose on Clam?
In case of overdose, the treatment should be provided according to the symptoms.
Symptoms of an overdose of Clam
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Clam Capsule, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at

Precautions while using Clam

Before you use Clam, tell your doctor of your medical and health history including the following:
  • a viral infection (mononucleosis)
  • allergic to beta-lactam antibiotics
  • blood cancer (leukemia)
Patients suffering from these conditions are at an increased risk for the occurrence of skin rash when using ampicillin. As a result, the use of ampicillin should be avoided in such patients.
Before you use Clam, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Discuss with your doctor if you are allergic to penicillins, or cephalosporins.

Use when Pregnant

The safety of the use of this medicine during pregnancy is not known. Consult with your doctor before using Clam during pregnancy or if you plan to become pregnant. There are no well-controlled studies of Clam available for pregnant women.

If Breastfeeding

It is not known if this medicine is safe for use in women who nurse/breastfeed. Consult with your doctor before you use Clam Capsule while breastfeeding. There are no well-controlled studies of Clam available for breastfeeding women.


Clam may cause seizures in some people. Hence, you should discuss with your doctor before performing any activities where a loss of consciousness may cause harm to you or others.

Side-effects in Children

Younger patients may have a higher incidence of side-effects with Clam Capsule. Younger patients may see an increased risk of jaundice.

Long-term Use

Long term use of Clam may cause overgrowth of resistant organisms.

Clam Side-effects

The following side-effects may commonly occur when using Clam Capsule. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in children when using Clam Capsule. Discuss with your doctor if any of these side-effects last for a long time or are severe:
Rarely, the use of Clam Capsule may cause the following side-effects:
  • involuntary jerking of the muscle
  • moderate and temporary increase in enzymes (transaminases)
  • purple discolored spots on the skin
The following severe side-effects may also occur when using Clam Capsule:
  • Nervous system disorders
    Symptoms: convulsions
  • Liver disorders
    Symptoms: hepatitis jaundice with a decreased flow of bile (cholestatic jaundice)
  • Skin disorders
    Symptoms: skin rash, severe allergic reactions (erythema multiforme, Stevens-Johnson syndrome) drug-induced severe allergic reaction
    If this happens, stop using this medicine.
  • Symptoms: anemia due to the breakdown of red blood cells, low white blood cell count, low platelet level low neutrophil cell count
  • Stomach and intestinal disorders
    Symptoms: diarrhea, vomiting, inflammation of the colon (pseudomembranous colitis) bacterial infection in the large intestine (hemorrhagic colitis)
  • Kidney disorders
    Symptoms: swelling in the spaces between kidney tubes (interstitial nephritis)
    If this happens, stop using this medicine.
Your doctor has prescribed Clam Capsule because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Clam Capsule.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at



Patients using aminoglycoside and Clam together are at an increased risk. If these medicines are mixed in the same container, the loss of activity due to an infusion solution may occur. In such cases, these medicines should not be mixed in one container.

Long-Term Use

Long term use of Clam may lead to overgrowth of resistant organisms.

Stomach Problems

Patients using antibiotics are at an increased risk. These patients may suffer from mild to life-threatening swelling of the large intestine. It is necessary to observe the swelling of the large intestine in patients who suffer from diarrhea while using or after the use of an antibiotic. Use of Clam should be stopped and the patient is examined further if a long term or significant diarrhea or stomach cramps are observed.

Kidney Problem

The dose of Clam should be adjusted in patients having a kidney problem.


Newborn babies having jaundice are at high risk. Cloxacillin may relocate bilirubin from its protein binding sites. Clam suspension and neonatal oral suspension containing sodium benzoate may cause irritation to eyes, skin and mucous membrane. Cloxacillin should be used with caution in the treatment of jaundice in newborn babies.

Sodium Content

Patients with a sodium-restricted diet are at an increased risk. In these patients, the sodium content of this medicine must be involved in their daily sodium diet allowance.

Oral Drops to Babies

Babies whose mothers are allergic to penicillin are at an increased risk while using Clam neonatal oral drops. Caution should be advised in such patients.

Prior Allergic Reaction

Careful monitoring should be conducted regarding prior allergic reaction to beta-lactam before starting Clam treatment.

Penicillins and Cephalosporins Use

Patients using penicillin with cephalosporins are at high risk. Caution is advised in such patients.

Allergic Reactions

Patients having allergy from beta-lactam are at high risk. It is reported that patients taking beta-lactam antibiotics may suffer from severe and irregular fatal allergic reactions. A severe allergic reaction is more likely to occur when penicillin is taken through injection as compared to oral therapy. The use of Clam should be stopped and start a suitable alternative treatment if an allergic reaction occurs. Treat the side effects according to the symptoms.


Skin rash has occurred with a viral infection (mononucleosis) or severe blood cancer after the use of ampicillin. If these conditions may be suspected, avoid the use of ampicillin in such patients.

Interactions with Clam

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Clam Capsule. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Uricosuric Agents

Clam Capsule may interact with probenecid, which is used to prevent gout. Probenecid lowers the elimination of Clam by the kidneys. Use of probenecid with Clam may lead to enhanced and prolonged blood levels of Clam.

Birth Controlling Pills

There may be an interaction of Clam with birth control pills, which are used to prevent pregnancy. Clam may affect the bacteria present in the stomach (gut flora) which leads to reduce the reabsorption of hormone (oestrogen) and decrease the effect of combined birth controlling pills.

Sulphonamides and Nonsteroidal Anti-Inflammatory Drugs

Clam Capsule interacts with sulphonamides and acetylsalicylic acid, which are used to treat bacterial infections and fever/pain respectively. Acetylsalicylic acid and sulphonamides prevent the blood protein binding of cloxacillin, and this may result in enhanced levels of cloxacillin in the blood.


Special instructions need to be followed while taking this medicine along with bacteriostatic drugs, which are used to prevent bacterial growth. Drugs that prevent the growth of bacteria may interfere with the bacterial damaging effect of Clam.

Xanthine Oxidase Inhibitors

Your doctor's guidelines may need to be followed while taking this medicine along with allopurinol, which is used to treat gout. Use of allopurinol with Clam may increase the possibilities of skin allergic reactions.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Clam is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Clam Capsule .
Bacterial Infections
Ear Infections
Infectious Diseases

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