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Why it's used

Clopilet Tablet is used to reduce the rate of stroke and heart attack. This medicine works by preventing the blood clot formation. Clopilet is also used to treat poor circulation in the legs (peripheral arterial disease) and chest pain due to heart problems, and to prevent conditions like irregular heartbeat and sudden reduction of blood flow to the heart.
Clopilet Tablet may also be used together with other medicines to treat certain conditions as recommended by the doctor. It is used in combination with Aspirin to lower the chances of heart attack, stroke, or blood clot formation.
Antiplatelet
Clopilet is a prescription medicine that belongs to a class of medicines called Antiplatelet. An antiplatelet drug is used for the treatment and prevention of heart attacks, stent thrombosis, and stroke caused by a blood clot. These medicines decrease the ability of platelets to stick together and hence reduce the formation of blood clots.

How to use

Read the medicine guide provided by your pharmacist, your doctor, or the medicine company. If you have any questions related to Clopilet, ask your doctor or pharmacist. Use Clopilet Tablet as per the instructions provided by your doctor.
Clopilet is eaten with or without food.
The typical dose of Clopilet for adults is 75 mg/day. Clopilet is commonly used at the same time every day. This medicine is not known to be addictive or habit-forming.
This medicine should be used on an as-needed basis. Clopilet should be used as directed by the doctor even if you feel well, or even if you think that there is no need for you to use your medicine.
Discuss with your doctor if your condition worsens. Discuss with your doctor if blood in the urine, black colored stools, vomiting with blood, and blood clot formation. Consult with your doctor before stopping the use of Clopilet.
When stopping this medicine, some patients may experience withdrawal symptoms like heart attack, and stroke.
The safety and effectiveness of using Clopilet Tablet in children has not been established. This medicine does not work in children.
Medicines may be recommended for uses other than those listed in the medicine guide. You should not use Clopilet Tablet for conditions or symptoms for which it was not prescribed. Do not give Clopilet Tablet to other people, even if they have the same conditions or symptoms that you have. The use of this medicine without the advice of a doctor may cause harm.
Follow storage instructions on the product package if available. Store Clopilet Tablet at room temperature 25° C (77° F), away from moisture, and away from light. Store this medicine away from children and pets.

How to take Clopilet

The dose and frequency of using Clopilet will depend on the following factors:
  • age of the patient
  • medicines recommended by the doctor
  • any other medicines being used
  • herbal supplements being used

Clopilet Dosage

Dosage for irregular heartbeat (atrial fibrillation)

Adult
  • Recommended: 75 mg/day

Dosage for sudden reduction of blood flow to the heart (acute coronary syndrome)

Adult
  • Recommended: 75 mg once daily
  • Initial: 300 mg loading dose

Dosage for heart attack

Adult
  • Recommended: 75 mg once daily

Dosage for stroke

Adult
  • Recommended: 75 mg once daily

Dosage for poor circulation in the legs (peripheral arterial disease)

Adult
  • Recommended: 75 mg once daily

Forms

Tablet
Strength: 75 mg, and 300 mg
Tablet, Film coated
Strength: 75 mg, and 300 mg

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed dose.

Overdose

What to do if you overdose on Clopilet?
No specific antidote is available for the Clopilet. In the case of overdose, another alternative method called platelet transfusion may be used to reverse the effects (prolonged bleeding time) of Clopilet.
Symptoms of an overdose of Clopilet
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Clopilet Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Clopilet

Before you use Clopilet Tablet, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic to clopidogrel, ticlopidine, or prasugrel.
Before you use Clopilet, tell your doctor of your medical history including stomach ulcers, bleeding problems, plan to have surgery and dental procedures, severe liver disease, bleeding within the brain, kidney disease, or allergic to Clopilet. Use of Clopilet in these existing conditions may lead to an increased risk of bleeding. Before having any surgery when using Clopilet, tell your doctor and dentist about all the medicinal products you use including prescription and non-prescription medicines, and any herbal supplements.
Clopilet Tablet should be used in pregnancy only when required. Clopilet should be used in pregnancy only if it is needed because no adequate and well-controlled studies have been carried out. Consult with your doctor on the use of Clopilet Tablet during breastfeeding. It is unknown whether Clopilet passes into the breast milk. Consult with your doctor on the use of Clopilet Tablet, if you are trying to conceive. It is unknown whether this medicine will harm the unborn baby.
Clopilet Tablet may cause seizures in some people. Discuss with your doctor if you perform activities where a loss of consciousness may cause you or others harm.
This medicine can cause stomach bleeding. The use of alcohol/tobacco with Clopilet may increase your stomach bleeding risk. If you drink alcohol or smoke regularly, please discuss with your doctor.

Clopilet Side-effects

The following side-effects may commonly occur when using Clopilet Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use of Clopilet Tablet may cause the following side-effects:
The following severe side-effects may also occur when using Clopilet Tablet:
  • brain related disorders
    Symptoms: confusion, hallucinations and bleeding inside the brain (intracranial bleeding)
  • immune system disorders
    Symptoms: life-threatening allergic reactions (anaphylactoid reactions) and allergic reaction to an injection of foreign protein
  • liver disorders
    Symptoms: acute liver failure, inflammation of the liver (hepatitis) and blood creatinine increased
  • stomach and intestinal disorders (possibly fatal)
    Symptoms: inflammation of the large intestine (colitis), inflammation in the pancreas (pancreatitis), painful swelling and sores inside the mouth, bleeding behind the peritoneum space (retroperitoneal hemorrhage) and stomach ulcers
  • blood and lymphatic system disorder (possibly fatal)
    Symptoms: deficiency of granulocytes in the blood, deficiency of blood cells (aplastic anemia), deficiency of red blood cells, white blood cells, and platelets (pancytopenia), clot formation in the small blood vessels, life-threatening blood disorder (acquired hemophilia A), low count of thrombocytes in the blood, low count of neutrophils in the blood, decreased number of white blood cells and high levels of eosinophils in the blood
  • Symptoms: tightening of the muscles of the lungs (bronchospasm), inflammation within the lungs (interstitial pneumonitis), build-up of white blood cells in the lungs (eosinophilic pneumonia), coughing up of blood (haemoptysis) and bleeding from the lung (pulmonary hemorrhage)
  • skin and subcutaneous tissue disorders
    Symptoms: skin allergic reaction caused by infection (erythema multiforme), life-threatening drug-induced skin reaction, swelling in the lower layer of skin, drug induced life-threatening allergic reaction, fluid-filled blisters on the skin (bullous dermatitis) and severe skin reaction (Stevens-Johnson Syndrome)
  • blood vessel disorders
    Symptoms: inflammation of a blood vessel (vasculitis), low blood pressure and bleeding (haemorrhage) after surgical procedure
  • heart disorders
    Symptoms: chest pain or heart attack due to allergic reaction (kounis syndrome)
  • bone disorders
    Symptoms: bleeding into joint spaces (haemarthrosis)
Your doctor has prescribed this Clopilet because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Clopilet.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Use of NSAIDs (Non-steroidal anti-inflammatory drugs)

Patients using NSAIDs with Clopilet may increase the risk of bleeding. Such patients should take necessary precautions while using NSAIDs with Clopilet especially during the first weeks of therapy.

Use of oral anticoagulants (warfarin)

Patients who are taking Clopilet with oral anticoagulants may increase the risk of bleeding. The combined use of Clopilet with oral anticoagulants is not recommended.

Patients who are planning to have surgery (elective surgery)

Such patients are at an increased risk when using this medicine. Discontinue the use of Clopilet seven days before undergoing the surgical procedure.

Patients with pathological conditions (trauma, or undergoing surgery)

These patients are at an increased risk of bleeding when using this medicine. Patients should carefully monitor for any signs of bleeding, especially during the first week of treatment and after surgery.

Life-threatening blood disorder (acquired haemophilia)

The patients who are using Clopilet are at an increased risk of a life-threatening blood disorder. Proper management by specialists or discontinuation of Clopilet is required in such patients.

Recurrent episodes of stroke

Patients with the continual episodes of stroke are at an increased risk when using this medicine. Avoid the use of Clopilet during the first seven days after an incidence of stroke.

Abnormal functioning of the kidney

Patients with abnormal functioning of the kidney are at an increased risk when using this medicine. Such patients should take necessary precautions while taking Clopilet.

Abnormal functioning of the liver

Patients with liver disease are at an increased risk when using this medicine. Take necessary precautions while using Clopilet.

Patients using CYP2C8 substrates (repaglinide)

Such patients are at an increased risk while using this medicine. The use of Clopilet with repaglinide may increase the level of repaglinide in the body. Patients should take necessary precautions while taking both drugs in combination.

Patients using CYP2C19 inhibitors (omeprazole)

Patients having poor metabolic activity are at an increased risk when using this medicine. Use of Clopilet with omeprazole decreases the blood clotting activity of Clopilet in patients with abnormal metabolism. Avoid the use of CYP2C19 inhibitors (omeprazole or esomeprazole) in such patients. Use another platelet inhibitors (P2Y12) in patients having poor metabolic activity.

Bleeding disorders

Patients who are taking thienopyridines are at an increased risk of bleeding. Thienopyridines may lead to blockage of blood clotting activity for 7-10 days. The process of platelet transfusion should be followed within 4 hours of starting dose or 2 hours of the maintenance dose.

Discontinuation of Clopilet

Patients who discontinue Clopilet therapy may at an increased risk of heart diseases.

Bleeding disorder with clotting in small blood vessels

Such patients are at an increased risk when using this medicine. This condition may cause low thrombocytes in the blood, deficiency of red blood cells (microangiopathic hemolytic anemia), fever, and kidney disorders. This condition requires urgent medical treatment including plasmapheresis (exchange of blood proteins).

Allergic reaction among thienopyridines

Patients who are taking thienopyridines are at an increased risk of allergic reactions. This allergic condition may lead to side effects such as swelling of the lower layer of the skin, low thrombocytes in the blood, skin rash, deficiency of neutrophils in the blood, and life-threatening allergic reaction. Regular monitoring for signs of allergic reaction in patients with a known allergy to thienopyridines is recommended.

Interactions with Clopilet

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Clopilet Tablet may interact with nonsteroidal anti-inflammatory drugs, which are used to treat pain, fever, swelling, and inflammation. The combined use of Clopilet with nonsteroidal anti-inflammatory drugs may increase the risk of stomach and intestinal bleeding. Patients should take necessary precautions while taking both drugs in combination.
There may be an interaction of Clopilet with warfarin, which is used to treat blood clots. The long-term use of Clopilet with warfarin increases the risk of bleeding. The use of Clopilet with warfarin is not recommended.
Clopilet Tablet interacts with selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors, which are used to treat depression. The use of Clopilet with these reuptake inhibitors increases the risk of bleeding. Patients should take necessary precautions while taking both drugs in combination.
Special instructions need to be followed while taking this medicine along with repaglinide, which is used to treat high blood sugar. Use of Clopilet with repaglinide may increase the level of repaglinide in the body. Take necessary precautions while taking both drugs in combination and proper dose adjustment is recommended.
Your doctor's guidelines may need to be followed while taking this medicine along with paclitaxel, which is used to treat cancer. Clopilet may increase the level of paclitaxel in the blood. Patients should take necessary precautions while taking both drugs in combination.
Clopilet Tablet may interact with CYP2C19 inhibitors such as fluvoxamine, moclobemide, fluoxetine, voriconazole, fluconazole, ticlopidine, carbamazepine, and efavirenz, which are used to treat depression, fungal or viral infections, stroke, and seizure. Use of Clopilet with CYP2C19 inhibitors may decrease the level of an active metabolite of Clopilet. Avoid the use of CYP2C19 inhibitors in patients who are on treatment with Clopilet.
There may be an interaction of Clopilet with proton pump inhibitors such as omeprazole or esomeprazole, which are used to treat stomach ulcers. Use of these inhibitors may reduce the level of the Clopilet metabolites in the blood and decrease the blood clotting activity. The combined use of proton pump inhibitors and Clopilet should be avoided.
Clopilet Tablet interacts with dexlansoprazole, lansoprazole, and pantoprazole, which are used to treat stomach acid production. Use of these medicines may decrease the blood clotting activity of Clopilet.
Special instructions need to be followed while taking this medicine along with glycoprotein IIb/IIIa inhibitors, which are used to prevent blood clotting. The use of Clopilet with glycoprotein IIb/IIIa inhibitors may increase the risk of bleeding. Patients should take necessary precautions while taking both drugs in combination.
Your doctor's guidelines may need to be followed while taking this medicine along with acetylsalicylic acid, which is used to treat pain, fever, and inflammation. The use of Clopilet with acetylsalicylic acid may increase the risk of bleeding. Take necessary precautions while taking both drugs in combination.
Clopilet Tablet may interact with heparin or thrombolytics, which are used to treat blood clots. The use of Clopilet with heparin or thrombolytics may increase the risk of bleeding. Patients should take necessary precautions while taking both drugs in combination.
There may be an interaction of Clopilet with pentoxifyllin, which is used to treat muscle pain. The use of Clopilet with pentoxifylline increases the risk of bleeding. Such patients should take necessary precautions while using pentoxifyllin with Clopilet especially during the first weeks of therapy.
This page does not contain all the possible interactions of Clopilet Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Clopilet is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.

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