Heart Disorders
Patients with heart diseases such as thrombotic heart events, heart attack, and
stroke may be at an increased risk. It may cause an increased risk of serious thrombotic heart events, heart attack, and stroke, which can be fatal. Patients should know about the signs or symptoms of serious heart disease and measures to take if they occur. Treatment should be started with the lowest effective dose for the shortest duration to minimize the risk of serious heart disease.
Stomach and Intestinal Adverse Events
Elderly patients, combined use of oral
corticosteroids or
anticoagulants and Declophen, patients who are on longer duration of
NSAID therapy,
alcohol use,
smoking, have poor general health status, and older age are at an increased risk for serious stomach and intestinal events such as
bleeding, ulceration and perforation. Patients should use the lowest effective dose for the shortest duration to reduce the risk of stomach or intestinal bleeding.
Prolonged treatment with Declophen
Patients taking Declophen are at an increased risk when using this medicine. Elevation of transaminases, high blood pressure, heart disease and
bleeding may occur. Long-term use of Declophen can result in damaged kidney cells and other kidney injuries. The medicine should be discontinued immediately if increased transaminases or blood pressure persist or worsen.
Elderly Patients
Elderly patients are at an increased risk when using this medicine. Long-term use of Declophen may result in damaged kidney cells and other kidney injuries. Patients should be cautious while taking this medicine.
Abnormal Functioning of Kidneys, Heart and Liver
Patients with abnormal functioning of kidneys, heart failure and liver dysfunction are at an increased risk when using this medicine. Long-term use of Declophen may result in damaged kidney cells and other kidney injuries. Patients should be cautious while taking this medicine.
Kidney Injury and Damaging of Kidney Cells
Patients taking
diuretics and
ACE-inhibitors therapy are at an increased risk when using this medicine. Long-term use of Declophen may result in damaged kidney cells and other kidney injuries. Patients should be cautious while taking this medicine.
Life-Threatening Allergic Reactions
Patients with aspirin-sensitive
asthma or patients without prior exposure to Declophen are at an increased risk when using this medicine. Severe or life-threatening allergic reaction (anaphylactoid reactions) may occur. Use this medicine with caution in patients with existing asthma.
Declophen Use in Pregnancy or Breastfeeding
Pregnant women is at an increased risk when using this medicine. This medicine should not be used by pregnant women.
Severe Skin Disorders (exfoliative dermatitis)
Such patients are at an increased risk when using this medicine. This may affect absorption and tolerability of the Declophen. It can cause serious skin adverse events such as severe skin reaction, and redness or peeling of the skin (exfoliative
dermatitis). Patients should discontinue the medicine at the first appearance of skin rash.
History of Stomach Ulcers
Patients with the history of stomach
ulcer or stomach and intestine disease are at an increased risk when using this medicine. These patients are at higher risk for developing
bleeding in the stomach or intestine when using this medicine. Patients should start with the lowest dose for the shortest duration to decrease the risk of bleeding.
Topical Use of Declophen
Patients using Declophen topically are at an increased risk when using this medicine. These patients are at an increased risk of irritation in the eyes. Such patients should wash their eyes and consult the doctor if irritation persists for more than one hour.
Undergoing Treatment with Corticosteroids
Patients taking
corticosteroid therapy are at an increased risk when using this medicine. These patients are at an increased risk of corticosteroid-induced illness after sudden discontinuation or substitution of corticosteroids with Declophen. Patients should discontinue corticosteroids slowly.
Blood Coagulation Disorders
Patients with coagulation disorders are at an increased risk when using this medicine. These patients may experience prolonged
bleeding when using Declophen. Careful monitoring should be done of the patients who are affected by the change in the
platelet function.
Non-Infectious and Painful Conditions
Patients with non-infectious and painful conditions are at an increased risk when using this medicine. Using Declophen in these patients may reduce the use of diagnostic signs such as
fever and inflammation.
Exposure to Sun
Patients with sun exposure are at an increased risk when using this medicine. These patients are at an increased risk of ultraviolet light-induced skin
cancer. Such patients should avoid exposure to sunlight.