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Exifine Tablet

Generic Name(s): Terbinafine

Why it's used

Exifine Tablet is used to treat Exifine sensitive fungal infections of the toenails or fingernails (onychomycosis), scalp, legs or arms (Tinea corporis), groin area (Tinea cruris) and soles of feet (Tinea pedis). It is a prescription medicine. This medicine works by blocking the growth of fungi.
Allylamine Antifungal
Exifine belongs to a class of medicines called Allylamine Antifungal. Allylamine antifungal medicines are used to treat fungal infections such as ringworm, athlete's foot, jock itch, and nail fungus. These medicines work by killing the growth of fungi.

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How to use

Follow directions on the product label, information guide, and provided by your doctor before using Exifine. Eat this medicine as per your doctor's instructions.
Exifine is eaten with or without food.

Typical Dosage

The typical adult dose of Exifine is 250 mg/day for 6-12 weeks. This medicine is commonly used for a period of 6 weeks for fungal infections of fingernail, 12 weeks for fungal infections of toenail, 2–4 weeks for fungal infection of the arms or legs (tinea corporis) and groin area (tinea cruris), and 6 weeks for fungal infection of the soles of the feet (tinea pedis).

Talk to Your Doctor

Tell your doctor if you develop new or worsening symptoms. Talk to your doctor if worsening lupus (autoimmune disorder), skin rash, loss of pigment, and unusual sensitivity to the sun.
Older patients may see an increase in the risk of side-effects. Hence, a lower dose may be recommended.

Lab Tests

Your doctor may require that certain tests be performed before using Exifine Tablet. The doctor may ask you to have Fungal Culture | Nail Biopsy | KOH Preparation test. Lab test such as fungal culture, KOH preparation, or nail biopsy should be performed for confirming the diagnosis of fungal infections of the toenails or fingernails (onychomycosis). Your doctor may request Aspartate Aminotransferase | Alanine Transaminase Blood | Liver Panel test. Measurement of the liver parameters such as aspartate aminotransferase and alanine transaminase should be performed before starting treatment with this medicine.

Storage

Store Exifine Tablet at 25°C (77°F), away from moisture, and away from light. Keep this medicine away from children and pets.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Exifine Tablet for symptoms for which it was not prescribed. Do not give Exifine Tablet to others who may have similar symptoms as you. Self-medication can cause harm.

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How to take Exifine

The dose and frequency of using Exifine will depend on the following factors:
  • age of the patient
  • medicines recommended by the doctor
  • any other medicines being used
  • herbal supplements being used

Exifine Dosage

Dosage for fungal infections of fingernail

Adult
  • Recommended: 250 mg/day for 6 weeks

Dosage for fungal infections of toenail

Adult
  • Recommended: 250 mg/day for 12 weeks

Forms

Tablet
Strength: 125 mg, 250 mg
Cream
Strength: 1 g/100 g, 1 g/100 g, 1 %
Granule
Strength: 125 mg, 187.5 mg
Spray
Strength: 1.25 ml/125 ml, 1 ml/100 ml, 1 %
Aerosol, spray
Strength: 0.84 g/125 ml
Gel
Strength: 10 mg, 10 mg/1 g
Solution
Strength: 1%

Special Instructions

Granules
For preparing dose of Exifine granules, a full packet of granules should be sprinkled on the spoonful of soft food such as mashed potatoes or pudding. Granules should not be sprinkled on the food made up of applesauce. If the doctor has asked you to take two packets of Exifine granules, You should sprinkle both packets on one spoonful or each packet on a separate spoonful of soft food. The spoonful of food and granules should be swallowed without chewing.

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued.

Overdose

What to do if you overdose on Exifine?
The harmful effects of Exifine can be reduced by taking activated charcoal which prevents the absorption of Exifine. If required, supportive treatment according to symptoms should be given in the management of overdose.
Symptoms of an overdose of Exifine
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Exifine Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Exifine

Before you use Exifine, tell your doctor of your medical and health history including the following:
Patient with liver disease may experience harmful effect and worsening of the functioning of the liver when using Exifine.
Before you use Exifine Tablet, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
The use of this medicine may change creatinine phosphokinase. It may increase the blood creatine phosphokinase level.
The use of Exifine Tablet may change liver function. The use of Exifine may increase level of the liver enzyme.
The use of this medicine may change complete blood count. The complete blood count may alter in a patient with immunodeficiency taking Exifine for more than six week.
The use of Exifine Tablet may change weight. Exifine may decrease the weight of patients.

Seizures

Exifine Tablet can make you feel sleepy. Be careful when using any machinery, driving a vehicle, or doing any other activity that needs you to be fully alert. The consumption of alcohol with Exifine Tablet can worsen the sleepiness. Exifine Tablet may cause rarely seizures in some people. If you perform any activities where a loss of consciousness may cause harm to you (or others), you should discuss with your doctor.

Use in Pregnancy

The use of Exifine during pregnancy should only be when required. Exifine should not be used in pregnancy but if necessary it should be used only after considering the possible benefit to the mother and potential risk to the fetus.

Use while Breastfeeding

The use of Exifine Tablet is not safe for use in women who are breastfeeding. If you are breastfeeding a baby, discuss with your doctor if you should either discontinue breastfeeding or stop using this medicine while breastfeeding. Exifine may pass into breast milk.

Use while Conceiving

Consult with your doctor on the use of Exifine, if you are trying to conceive.

Increased Risks

This medicine may increase your sensitivity to sunlight. If this happens, use a sunscreen and cover your skin when you are outdoors. Limit your time in the sun.

What precautions should be taken during Pregnancy and Nursing, and administering Exifine to Children or the Older Adults?

Breastfeeding

Contraindicated or Not Recommended
Warning: Exifine may pass into breast milk.

Younger Adults Population

No Known Risk
Warning: Safety and efficacy of Exifine in children are unknown.

Older Adults Population

Precaution
Warning: Elderly patients have decreased functioning of the kidney, liver, and heart so lower dose should be taken in these patients.

Exifine Side-effects

The following side-effects may commonly occur when using Exifine Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use of Exifine Tablet may cause the following side-effects:
  • altered prothrombin time
  • burning or prickling sensation
  • decreased weight
  • dizziness
  • fatigue
  • feeling of discomfort
  • hair loss
  • hypoacusis/hearing loss
  • increased liver enzymes
  • inflammation of the connective tissues (cutaneous and systemic lupus erythematosus)
  • influenza like illness
  • red, dry, itchy, and scaly on the skin (psoriasiform eruptions/exacerbation of psoriasis)
  • reduced sense of touch or sensation
  • ringing in the ears (tinnitus)
  • sensation of spinning dizziness
  • visual disturbance including reduced visual acuity, visual field defect
The following severe side-effects may also occur when using Exifine Tablet:
  • Symptoms: low count of neutrophils in the blood, deficiency of granulocyts, abnormally low levels of thrombocytes, deficiency of red cells, white cells, and platelets lack of blood
    If this happens, stop taking Exifine and contact your doctor as soon as possible.
  • immune system disorders
    Symptoms: life-threatening allergic reaction (anaphylaxis), swelling of the lower layer of the skin allergic reaction to an injection of foreign protein
    If this happens, contact your doctor as soon as possible.
  • mental disorders such as anxiety and depression
    Symptoms: feel sad or worthless, change in sleep pattern, loss of energy or interest in daily activities, restlessness mood changes
    If these symptoms occur, contact your doctor as soon as possible.
  • nervous system disorders such as loss of taste and loss of smell
    Symptoms: decreased appetite, weight loss anxious or depressed feelings
    If this happens, stop taking Exifine and contact your doctor as soon as possible.
  • blood vessel disorder
    Symptoms: inflammation of a blood vessel (vasculitis)
  • stomach and intestinal disorder
    Symptoms: pancreas inflammation (pancreatitis)
    If this happens, contact your doctor as soon as possible.
  • liver disorders (possibly fatal)
    Symptoms: nausea, upper right stomach pain, poor appetite, yellowing of the skin or eyes, tiredness, dark (tea-colored) urine, vomiting, pale or light-colored stools, inflammation of the liver (hepatitis), liver failure blocked or reduced flow of bile from the liver (cholestasis)
    If this happens, stop taking Exifine and contact your doctor as soon as possible. In this case, the blood test should be performed for liver problems before using Exifine.
  • skin disorders
    Symptoms: skin allergic reaction caused by infection, life-threatening skin reaction (Stevens-Johnson Syndrome), life-threatening drug-induced skin reaction, red, scaly rash with bumps under the skin (acute generalized exanthematous pustulosis) sun allergic reaction
    If this happens, stop taking Exifine and contact your doctor as soon as possible.
  • musculoskeletal and connective tissue disorder
    Symptoms: muscle injury (rhabdomyolysis)
    If this happens, contact your doctor as soon as possible.
  • increased blood creatinine phosphokinase | fever |
    If this happens, contact your doctor as soon as possible.
Your doctor has prescribed this medicine because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious cases of side-effects. This page does not contain a complete list of all possible side-effects.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Exifine by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
If this happens, stop taking Exifine and contact your doctor as soon as possible.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Skin Reactions

Patients taking Exifine are at an increased risk. These patients may experience serious skin reaction such as life-threatening allergic reactions and drug-induced life-threatening allergic reactions. Exifine should be discontinued on the occurrence of progressive skin rash.

Inflammation of the Connective Tissues (Lupus Erythematous)

Patients taking Exifine are at an increased risk. These patients may experience lupus erythematosus. Exifine should be discontinued on the occurrence of signs and symptoms of lupus erythematosus. Precaution should be taken in patients with psoriasis or lupus erythematosus.

Medicinal Products Metabolized by CYP2D6

Patients taking Exifine with medicinal products metabolized by CYP2D6 are at an increased risk. Dose adjustment should be considered in such patients.

Functioning Of the Kidney

Patients with an abnormality in the functioning of the kidney are at an increased risk. Exifine should not be in such patients.

Harmful Effects on Liver

Patients using Exifine, with and without liver disease are at an increased risk. These patients may experience nausea, fatigue, stomach pain, jaundice, dark urine, eating disorder (anorexia), pale stools, harmful effects of the liver, or liver failure which may lead to liver transplant or fatality. If this happens, stop taking Exifine and contact your doctor as soon as possible. In this case, the blood test should be performed for liver problems before using Exifine.

Taste Disturbance

Patients taking Exifine are at an increased risk. These patients may experience taste disturbance such as taste loss, which may lead to weight loss, decreased food intake, and depressive symptoms. Exifine should be discontinued on the occurrence of taste disturbance. These symptoms may resolve after discontinuation of Exifine therapy, but these symptoms may be prolonged or permanent.

Smell Disturbance

Patients taking Exifine are at an increased risk. These patients may experience smell disturbance such as loss of smell. Exifine should be discontinued on the occurrence of smell disturbance. These symptoms may resolve after discontinuation of Exifine therapy but may be prolonged or permanent.

Depressive Symptoms

Patients taking Exifine are at an increased risk. These patients may experience depressive symptoms. Patients should be informed to report the doctor immediately on the occurrence of depressive symptoms.

Blood-Related Effects

Patients taking Exifine are at an increased risk. These patients may experience low levels of blood cells such as neutrophils, granulocytes, thrombocytes, white blood cells, platelets or red blood cells, fever, and sore throat. Complete blood count test and blood-related effects should be examined on the occurrence of symptoms of secondary infection and in patients with immunodeficiency using Exifine for more than six weeks. Exifine should be discontinued on the occurrence of severe low levels of blood cells. Also, dose adjustment and supportive therapy should be considered in such cases.

Interactions with Exifine

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Exifine Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Drugs Metabolised by CYP2D6

Exifine Tablet may interact with drugs metabolised by CYP2D6 (beta-blockers, antiarrhythmics, desipramine). When Exifine is used with drugs metabolized by CYP2D6 such as beta-blockers, antiarrhythmics, tricyclic antidepressants, selective serotonin inhibitors, or monoamine oxidase inhibitors, it may interfere in the metabolism of these drugs. Exifine may decrease the clearance of desipramine. Dose reduction along with monitoring should be considered in patients using these medicines together.

Caffeine

There may be an interaction of Exifine with caffeine, which is used to treat headache. When Exifine is used with caffeine, it may decrease the clearance of caffeine.

Ciclosporin

Exifine Tablet interacts with ciclosporin, which is used to prevent organ rejection. When Exifine is used with ciclosporin, it may increase the clearance of ciclosporin.

Warfarin

Special instructions need to be followed while taking this medicine along with warfarin, which is used to reduce the risk of heart attack. When Exifine is used with warfarin, it may either increase or decrease the blood clotting time.

Rifampin

Your doctor's guidelines may need to be followed while taking this medicine along with rifampin, which is used to treat lung infection (tuberculosis). When Exifine is used with rifampin, it may increase the clearance of the Exifine. Dose adjustments of Exifine should be considered when using both medicines together.

Cimetidine

Exifine Tablet may interact with cimetidine, which is used to treat ulcer. When Exifine is used with cimetidine, it may decrease the clearance of the Exifine. Dose adjustments of Exifine should be considered when using both medicines together.

Antifungals

There may be an interaction of Exifine with antifungals (fluconazole and ketoconazole), which is used to treat fungal infection. When Exifine is used with fluconazole or ketoconazole, it may increase the levels of Exifine.

Amiodarone

Exifine Tablet interacts with amiodarone, which is used to treat irregular heartbeat. When Exifine is used with amiodarone, it may increase the levels of Exifine.

Oral contraceptives

Special instructions need to be followed while taking this medicine along with oral contraceptives, which is used to prevent pregnancy. When Exifine is used with oral contraceptives, it may cause irregular menstruation.

Interactions of Exifine by Severity

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Exifine be not used?

Allergic to Exifine

This medicine should not be used in patients with a history of allergy to Exifine. Patients may see an increased risk of life-threatening allergic reaction. These patients may have the following symptoms if they use this medicine:
  • skin rash
  • hives
  • mouth sores
  • skin blisters
  • peels swelling of the face, eyes, lips, tongue or throat
  • trouble swallowing or breathing
  • life-threatening allergic reaction
  • skin allergic reaction caused by infection (erythema multiforme)
  • life-threatening skin reaction (Stevens-Johnson Syndrome)
  • life-threatening drug-induced skin reaction
  • red, scaly rash with bumps under the skin (acute generalized exanthematous pustulosis)
  • hair loss
  • sun allergic reaction (photosensitivity reaction/photodermatosis/polymorphic light eruption)

Severe Abnormal Functioning of the Kidney

Exifine should not be used in patients with severe abnormal functioning of the kidney.

Severe Liver Problems

Exifine should not be used in patients with a severe liver problem. Patients may see an increased risk of the harmful effect of the liver. These patients may have the following symptoms if they use this medicine:

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Exifine is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Exifine Tablet .
Fungal Infections
Opioids
Tinea Infections
Infectious Diseases

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