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    Alzheimer's Disease

    Health    Alzheimer's Disease
    Also called: AD

    Alzheimer's disease (AD) is the most common form of dementia among older people. Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities.

    AD begins slowly. It first involves the parts of the brain that control thought, memory and language. People with AD may have trouble remembering things that happened recently or names of people they know. A related problem, mild cognitive impairment (MCI), causes more memory problems than normal for people of the same age. Many, but not all, people with MCI will develop AD.

    In AD, over time, symptoms get worse. People may not recognize family members. They may have trouble speaking, reading or writing. They may forget how to brush their teeth or comb their hair. Later on, they may become anxious or aggressive, or wander away from home. Eventually, they need total care. This can cause great stress for family members who must care for them.

    AD usually begins after age 60. The risk goes up as you get older. Your risk is also higher if a family member has had the disease.

    No treatment can stop the disease. However, some drugs may help keep symptoms from getting worse for a limited time.

    NIH: National Institute on Aging

    Symptoms of Alzheimer's Disease

    The following features are indicative of Alzheimer's Disease:
    • memory problems
    • mild cognitive impairment
    • movement difficulties
    • sense of smell problems
    • word-finding
    • vision or spatial issues
    • impaired reasoning or judgment
    References: 1

    Common Causes of Alzheimer's Disease

    The following are the most common causes of Alzheimer's Disease:
    • genetic mutation in the apolipoprotein E (APOE) gene
    • obesity
    • diabetes
    • high blood pressure
    • heart disease
    References: 1, 2

    Risk Factors of Alzheimer's Disease

    The following factors may increase the likelihood of Alzheimer's Disease:
    • environmental factors
    • older adults
    • family history

    Prevention of Alzheimer's Disease

    No, it is not possible to prevent Alzheimer's Disease.
    • genetic mutations in APP, PSEN1, or PSEN2
    References: 3

    Occurrence of Alzheimer's Disease.

    Degree of Occurrence

    The following are number of Alzheimer's Disease cases seen each year worldwide:
    • Very common > 10 Million cases

    Common Age Group

    Alzheimer's Disease most commonly occurs in the following age group:
    • Aged > 50 years

    Common Gender

    Alzheimer's Disease most commonly occurs in the following gender:
    • Not gender specific
    References: 2, 3

    Lab Tests and Procedures for Diagnosis of Alzheimer's Disease

    The following lab tests and procedures are used to detect Alzheimer's Disease:
    • Mini–mental state examination: To diagnose the cognitive impairments
    • Blood tests: To detect other causes of dementia
    • Psychological tests: To diagnose depression
    References: 3, 4

    Doctor for Diagnosis of Alzheimer's Disease:

    Patients should visit the following specialists if they have symptoms of Alzheimer's Disease:
    • Geriatricians
    • Geriatric psychiatrists
    • Neurologists
    • Neuropsychologists

    Complications of Alzheimer's Disease if Untreated

    Yes, Alzheimer's Disease causes complications if it is not treated. Below is the list of complications and problems that may arise if Alzheimer's Disease is left untreated:
    • pneumonia
    • falls
    • fractures
    • bedsores
    • malnutrition
    References: 5

    Procedures for Treatment of Alzheimer's Disease

    The following procedures are used to treat Alzheimer's Disease:
    • Supportive psychotherapy: Helps mildly impaired people to adjust their illness
    • Reminiscence therapy: Discussion of past experiences personally or in group with the help of household items, photographs, sound recordings and music for mood and cognition
    • Simulated presence therapy: To reduce challenging behaviours by playing a voice recording of the close relatives of the patients
    • Validation therapy: Acceptance of the reality and personal truth of another's experience
    References: 6

    Self-care for Alzheimer's Disease

    The following self-care actions or lifestyle changes may help in the treatment or management of Alzheimer's Disease:
    • Have healthy Diet: Take a diet which is rich in fruits and vegetables and low in fat
    • Exercise regularly
    • Get socially engaged: Helps to preserve mental function
    References: 7

    Alternative Medicine for Treatment of Alzheimer's Disease

    The following alternate medicine and therapies are known to help in the treatment or management of Alzheimer's Disease:
    • Physical therapy: Do exercise regularly to improve mood and maintain the health of heart, muscles and joints
    • Nutrition: Take diet enriched with nutrition
    References: 8

    Patient Support for Treatment of Alzheimer's Disease

    The following actions may help Alzheimer's Disease patients:
    • Calm and stable home environment: Reduce behavior problems
    • Education: Learn much about the disease
    • Join a support group: Interact with other people with the same condition to deal with your problems
    References: 7

    Time for Treatment of Alzheimer's Disease

    While time-period of treatment for each patient may vary, below is the typical time-period for Alzheimer's Disease to resolve if treated properly under an expert supervision:
    • Disease cannot be treated but only maintained or effects reduced
    References: 6

    Questions - Alzheimer's Disease

    No questions have been asked.

    News, Updates and Latest Articles - Alzheimer's Disease

    Latest news and updates related to Alzheimer's Disease. Subscribe to get latest posts via email or subscribe to a RSS feed.

    Researchers propose new theory for how rare gene mutations cause Alzheimer's disease

    Tuesday, August 14, 2018 -- A University of Adelaide-led team of scientists has suggested a potential link between iron in our cells and the rare gene mutations that cause Alzheimer's disease, which could provide new avenues for future research.

    Study shows link between use of benzodiazepines and increased risk of Alzheimer's disease

    Monday, August 13, 2018 -- The use of benzodiazepines and related drugs (Z drugs) is associated with a modestly increased risk of Alzheimer's disease, according to a recent study from the University of Eastern Finland.

    Confabulations Linked to Impaired Mental Time Travel in Alzheimer Disease

    Monday, August 06, 2018 -- The findings suggest that confabulations by patients with AD are related to an impaired ability to mentally go back in time to retrieve the context in which the confabulated memories were encoded.

    New method to construct brain networks improves accuracy of diagnosing Alzheimer's disease

    Wednesday, August 01, 2018 -- Researchers have developed a new method for constructing personal brain networks using multiple structural features to improve the accuracy of diagnosing Alzheimer's disease and mild cognitive impairment

    Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention

    Wednesday, July 25, 2018 -- Humans possess three genetic isoforms of apolipoprotein E (ApoE)—ApoE2, ApoE3, and ApoE4—that confer differential risk for Alzheimer's disease (AD); however, the underlying mechanisms are poorly understood. This study sought to investigate the impact of human ApoE isoforms on brain energy metabolism, an area significantly perturbed in preclinical AD. A TaqMan custom array was performed to examine the expression of a total of 43 genes involved in glucose and ketone body transport and metabolism, focusing on pathways leading to the generation of acetyl-CoA, in human ApoE gene-targeted replacement female mice. Consistent with our previous findings, brains expressing ApoE2 exhibited the most robust profile, whereas brains expressing ApoE4 displayed the most deficient profile on the uptake and metabolism of glucose, the

    References

    1. NIH Alzheimer's Disease Fact Sheet https://www.nia.nih.gov/alzheimers/publi... - Accessed: February 20, 2017.
    2. NIH Preventing Alzheimer’s Disease: What Do We Know? https://www.nia.nih.gov/alzheimers/publi... - Accessed: February 20, 2017.
    3. Wikipedia Alzheimer's disease https://en.wikipedia.org/wiki/Alzheimer&... - Accessed: February 20, 2017.
    4. NIH About Alzheimer's Disease: Diagnosis https://www.nia.nih.gov/alzheimers/topic... - Accessed: February 20, 2017.
    5. Mayo Clinic Alzheimer's disease http://www.mayoclinic.org/diseases-condi... - Accessed: February 20, 2017.
    6. Wikipedia Alzheimer's disease https://en.wikipedia.org/wiki/Alzheimer%... - Accessed: February 20, 2017.
    7. Mayo Clinic Alzheimer's disease http://www.mayoclinic.org/diseases-condi... - Accessed: February 20, 2017.
    8. Mayo Clinic Alzheimer's disease https://www.mayoclinic.org/diseases-cond... - Accessed: February 20, 2017.
    9. Source: https://medlineplus.gov/alzheimersdisease.html

    Last updated date

    This page was last updated on 8/05/2018.
    This page provides information for Alzheimer's Disease.

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