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    Crohn's Disease

    Health    Crohn's Disease
    Also called: Regional enteritis, Regional ileitis

    Crohn's disease causes inflammation of the digestive system. It is one of a group of diseases called inflammatory bowel disease. Crohn's can affect any area from the mouth to the anus. It often affects the lower part of the small intestine called the ileum.

    The cause of Crohn's disease is unknown. It may be due to an abnormal reaction by the body's immune system. It also seems to run in some families. It most commonly starts between the ages of 13 and 30.

    The most common symptoms are pain in the abdomen and diarrhea. Other symptoms include

    • Bleeding from the rectum
    • Weight loss
    • Fever

    Your doctor will diagnose Crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy.

    Crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. People with Crohn's can also have joint pain and skin problems. Children with the disease may have growth problems.

    There is no cure for Crohn's. Treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. Some people have long periods of remission, when they are free of symptoms.

    NIH: National Institute of Diabetes and Digestive and Kidney Diseases

    Symptoms of Crohn's Disease

    The following features are indicative of Crohn's Disease:
    • diarrhoea
    • fever
    • fatigue
    • abdominal pain and cramping
    • blood in the stool
    • mouth sores
    • reduced appetite
    • weight loss
    • perianal disease
    References: 1

    Common Causes of Crohn's Disease

    The following are the most common causes of Crohn's Disease:
    • weakened immune system
    • heredity
    References: 2, 3

    Risk Factors of Crohn's Disease

    The following factors may increase the likelihood of Crohn's Disease:
    • young age
    • whites and people of Eastern European (Ashkenazi) Jewish descent
    • family history
    • cigarette smoking
    • nonsteroidal anti-inflammatory medications
    • place of living

    Prevention of Crohn's Disease

    Yes, it may be possible to prevent Crohn's Disease. Prevention may be possible by doing the following:
    • limit dairy products
    • take low fat foods
    • limit fiber
    • eat small meals
    • drink plenty of liquids
    • take multivitamins
    • avoid spicy food
    References: 4

    Occurrence of Crohn's Disease.

    Degree of Occurrence

    The following are number of Crohn's Disease cases seen each year worldwide:
    • Rare between 10K - 50K cases

    Common Age Group

    Crohn's Disease most commonly occurs in the following age group:
    • Aged between 20-50 years

    Common Gender

    Crohn's Disease most commonly occurs in the following gender:
    • Not gender specific
    References: 5

    Lab Tests and Procedures for Diagnosis of Crohn's Disease

    The following lab tests and procedures are used to detect Crohn's Disease:
    • Tests for anemia or infection: these are conducted to diagnose anemia
    • Fecal occult blood test: It is performed to find blood discharge in the stool
    • Colonoscopy: To find out the presence of inflammatory cells
    • Flexible sigmoidoscopy: It is conducted to examine the last section of colon
    • Computerized tomography: It is performed to examine bowel as well as tissues outside the bowel
    • Magnetic resonance imaging (MRI): It is used to check the development of fistula around anal area
    • Capsule endoscopy: This is for detailed image analysis of the internal organs
    • Double-balloon endoscopy: It is used to look further into the small bowel
    References: 6

    Doctor for Diagnosis of Crohn's Disease:

    Patients should visit the following specialists if they have symptoms of Crohn's Disease:
    • Gastroenterologist
    • Surgeon
    • Pathologist
    • Radiologist

    Complications of Crohn's Disease if Untreated

    Yes, Crohn's Disease causes complications if it is not treated. Below is the list of complications and problems that may arise if Crohn's Disease is left untreated:
    • inflammation
    • bowel obstruction
    • ulcer
    • fistulas
    • anal fissure
    • malnutrition
    • colon cancer
    References: 6

    Procedures for Treatment of Crohn's Disease

    The following procedures are used to treat Crohn's Disease:
    • Surgery: To widen a segment of the intestine that has become too narrow
    References: 7

    Self-care for Crohn's Disease

    The following self-care actions or lifestyle changes may help in the treatment or management of Crohn's Disease:
    • Limit dairy products: Helps preventing inflammatory bowel disease symptoms
    • Try low-fat foods: Helps treating Crohn's disease of the small intestine
    • Limit fiber food: Helps in preventing symptoms from worsening
    • Avoid smoking: Helps preventing crohn's disease
    References: 4

    Alternative Medicine for Treatment of Crohn's Disease

    The following alternate medicine and therapies are known to help in the treatment or management of Crohn's Disease:
    • Acupuncture therapy: Helps managing crohn's disease
    • Intake of prebiotics and probiotics: May help in treating crohn's disease
    References: 8

    Patient Support for Treatment of Crohn's Disease

    The following actions may help Crohn's Disease patients:
    • Education: Helps providing information and coping with condition
    • Join a support group: Helps coping with situation
    References: 9

    Time for Treatment of Crohn's Disease

    While time-period of treatment for each patient may vary, below is the typical time-period for Crohn's Disease to resolve if treated properly under an expert supervision:
    • In 1 - 3 months
    References: 10

    Related Topics - Crohn's Disease

    Questions - Crohn's Disease

    News, Updates and Latest Articles - Crohn's Disease

    Latest news and updates related to Crohn's Disease. Subscribe to get latest posts via email or subscribe to a RSS feed.

    IL-23-Specific Antibody Ups Response in Anti-TNF-Refractory Crohn's

    Thursday, August 02, 2018 -- (MedPage Today) -- Subcutaneous risankizumab also looks promising for maintaining remission

    Anti-MAP Therapy Beneficial in Phase 3 Crohn's Disease Trial

    Wednesday, August 01, 2018 -- The randomized, double-blind, placebo-controlled study (N=331) achieved its primary endpoint and key secondary endpoints in the intent-to-treat (ITT) population.

    RedHill BioPharma has positive results from Crohn's disease trial

    Monday, July 30, 2018 -- Israel's RedHill Biopharma said on Monday it had positive safety and efficacy results from a late-stage clinical trial with its treatment for Crohn's disease called RHB-104.

    [Articles] Risankizumab in patients with moderate to severe Crohn's disease: an open-label extension study

    Wednesday, July 25, 2018 -- Extended induction treatment with open-label intravenous risankizumab was effective in increasing clinical response and remission rates at week 26. Open-label subcutaneous risankizumab maintained remission until week 52 in most patients who were in clinical remission at week 26. Selective blockade of interleukin 23 warrants further investigation as a treatment for Crohn's disease.

    Johnson & Johnson, looking for its Tremfya niche, starts up new trial program in Crohn's

    Wednesday, July 11, 2018 -- Johnson & Johnson immunology newcomer Tremfya is looking to follow in the footsteps of its big brother Stelara. The company launched a phase 2/3 clinical trial program to test the therapy in Crohn’s disease, a new indication that would broaden its reach considerably.

    References

    1. Mayo Clinic Crohn's disease http://www.Mayo - Accessed: February 20, 2017. Clinic.org/diseases-conditions/crohns-disease/basics/symptoms/con-20032061
    2. Mayo Clinic Crohn's disease http://www.mayoclinic.org/diseases-condi... - Accessed: February 20, 2017.
    3. Mayo Clinic Crohn's disease http://www.mayoclinic.org/diseases-condi... - Accessed: February 20, 2017.
    4. Mayo Clinic Crohn's disease http://www.mayoclinic.org/diseases-condi... - Accessed: February 20, 2017.
    5. Wikipedia Crohn's disease https://en.wikipedia.org/wiki/Crohn'... - Accessed: February 20, 2017.
    6. Mayo Clinic Crohn's disease http://www.mayoclinic.org/diseases-condi... - Accessed: February 20, 2017.
    7. Mayo Clinic Crohn's disease http://www.mayoclinic.org/diseases-condi... - Accessed: February 20, 2017.
    8. Mayo Clinic Crohn's disease http://www.mayoclinic.org/diseases-condi... - Accessed: February 20, 2017.
    9. Mayo Clinic Crohn's disease http://www.mayoclinic.org/diseases-condi... - Accessed: February 20, 2017.
    10. NIH Treatment for Crohn’s Disease https://www.niddk.nih.gov/health-informa... - Accessed: February 20, 2017.
    11. Source: https://medlineplus.gov/crohnsdisease.html

    Last updated date

    This page was last updated on 7/27/2018.
    This page provides information for Crohn's Disease.

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