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A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001)

Symptoms of Follicular Lymphoma

The following features are indicative of Follicular Lymphoma:
  • painless swelling in the neck, armpit or groin
  • chest pain
  • coughing
  • trouble breathing
  • fatigue
  • fever
  • unexplained weight loss
It is possible that Follicular Lymphoma shows no physical symptoms and still be present in a patient.

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Common Causes of Follicular Lymphoma

The following are the most common causes of Follicular Lymphoma:
  • genetic mutations

Risk Factors for Follicular Lymphoma

The following factors may increase the likelihood of Follicular Lymphoma:
  • mutations in the BCL6 at 3q27 genes

Prevention of Follicular Lymphoma

Yes, it may be possible to prevent Follicular Lymphoma. Prevention may be possible by doing the following:
  • maintain a healthy immune system
  • maintain a healthy weight
  • eat a healthy diet

Occurrence of Follicular Lymphoma

Number of Cases

The following are the number of Follicular Lymphoma cases seen each year worldwide:
  • Common between 1 - 10 Million cases

Common Age Group

Follicular Lymphoma most commonly occurs in the following age group:
  • Aged > 50 years

Common Gender

Follicular Lymphoma can occur in any gender.

Lab Tests and Procedures for Diagnosis of Follicular Lymphoma

The following lab tests and procedures are used to detect Follicular Lymphoma:
  • Physical examination: To diagnose the size and condition of lymph nodes
  • Blood and urine tests: To diagnose infection and other disease
  • CT scan: To diagnose tumors in the body
  • PET: To diagnose tumors in the body
  • Biopsy: To get a sample of lymph node for testing

Doctor for Diagnosis of Follicular Lymphoma

Patients should visit the following specialists if they have symptoms of Follicular Lymphoma:
  • Hematologist
  • Oncologist

Complications of Follicular Lymphoma if untreated

Yes, Follicular Lymphoma causes complications if it is not treated. Below is the list of complications and problems that may arise if Follicular Lymphoma is left untreated:
  • bone and neurologic lesions

Procedures for Treatment of Follicular Lymphoma

The following procedures are used to treat Follicular Lymphoma:
  • Chemotherapy: To kill cancer cells
  • Radiation therapy: To kill cancer cells or reduce tumors with high-powered energy beams
  • Stem cell transplant: To kill lymphoma cells

Self-care for Follicular Lymphoma

The following self-care actions or lifestyle changes may help in the treatment or management of Follicular Lymphoma:
  • Exercise: To reduce or prevent lymphoma
  • Quit smoking: Avoid the use of tobacco helps prevent condition to worsen

Related Topics

Last updated date

This page was last updated on 2/04/2019.
This page provides information for Follicular Lymphoma.

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