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A clonal myeloproliferative neoplasm characterized by the proliferation and accumulation of neoplastic mast cells in one or multiple organs or organ systems. It is a heterogeneous group of neoplasms, ranging from cutaneous proliferations which may regress spontaneously, to aggressive neoplasms associated with organ failure and short survival.

Symptoms of Mastocytosis

The following features are indicative of Mastocytosis:
  • facial flushing
  • itching
  • rapid heartbeat
  • lightheadedness
  • loss of consciousness
  • fatigue
  • skin lesions
  • abdominal discomfort
  • nausea
  • vomiting
  • diarrhea
  • bronchitis
  • faintness
  • muscle pain
  • decreased bone density
  • increased stomach acid production

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Common Causes of Mastocytosis

The following are the most common causes of Mastocytosis:
  • mutations in the KIT gene

Risk Factors for Mastocytosis

The following factors may increase the likelihood of Mastocytosis:
  • alcohol consumption
  • temperature changes
  • eating spicy foods
  • increased basal serum tryptase values
  • extensive blistering

Prevention of Mastocytosis

Yes, it may be possible to prevent Mastocytosis. Prevention may be possible by doing the following:
  • administration of creams and ointments on skin lesions

Occurrence of Mastocytosis

Number of Cases

The following are the number of Mastocytosis cases seen each year worldwide:
  • Rare between 10K - 50K cases

Common Age Group

Mastocytosis most commonly occurs in the following age group:
  • Aged between 1-5 years

Common Gender

Mastocytosis can occur in any gender.

Lab Tests and Procedures for Diagnosis of Mastocytosis

The following lab tests and procedures are used to detect Mastocytosis:
  • Skin biopsy: Helps to confirm the diagnosis of Mastocytosis

Doctor for Diagnosis of Mastocytosis

Patients should visit the following specialists if they have symptoms of Mastocytosis:
  • Oncologist
  • Allergy specialist
  • Hematologist

Complications of Mastocytosis if untreated

Yes, Mastocytosis causes complications if it is not treated. Below is the list of complications and problems that may arise if Mastocytosis is left untreated:
  • osteoporosis
  • osteopenia

Procedures for Treatment of Mastocytosis

The following procedures are used to treat Mastocytosis:
  • Psoralen and ultraviolet A radiation (PUVA) therapy: Helps in treatment of severe skin diseases

Self-care for Mastocytosis

The following self-care actions or lifestyle changes may help in the treatment or management of Mastocytosis:
  • Administration of skin creams: Relieves the skin lesions

Patient Support for Treatment of Mastocytosis

The following actions may help Mastocytosis patients:
  • Support and advocacy groups support: Helps to connect patients and families and provide valuable services for better treatments and possible cures of Mastocytosis

Time for Treatment of Mastocytosis

While time-period of treatment for each patient may vary, below is the typical time-period for Mastocytosis to resolve if treated properly under an expert supervision:
  • In 6 months - 1 year

Last updated date

This page was last updated on 2/04/2019.
This page provides information for Mastocytosis.

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