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Why it's used

Angizaar-50 Tablet is a prescription medicine that is used to treat high blood pressure. This medicine works by preventing the activity of certain natural substances that tighten the blood vessels. This medicine helps by making blood flowing smoothly and the heart to pump more effectively. Angizaar-50 Tablet is also used to reduce the risk of stroke in high blood pressure patients with an enlarged heart, and to treat kidney damage due to diabetes.
Angizaar-50 Tablet may also be used along with other medicines in the treatment of certain conditions as recommended by the doctor. It is used with Hydrochlorothiazide to reduce the risk of stroke in high blood pressure patients with an enlarged heart.
Angiotensin 2 Receptor Blocker
Angizaar-50 belongs to the Angiotensin 2 Receptor Blocker class of medicines. Angiotensin II receptor blockers are used for the treatment of high blood pressure and heart failure. These medicines act by relaxing the blood vessels and makes it easier for your heart to pump blood.

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How to use

Read the medicine guide provided by your pharmacist, your doctor, or the medicine company. If you have any questions related to Angizaar-50, ask your doctor or pharmacist. Use Angizaar-50 Tablet as per the instructions provided by your doctor.
You should keep track of your blood pressure levels regularly. Share results with the doctor and discuss your treatment plan if your measurements areabnormally high or low
Angizaar-50 is consumed with or without food. If a child is unable to swallow a tablet, a liquid form (suspension) is given after consultation with the pharmacist or doctor.

Typical Dosage

The typical dose of Angizaar-50 for adults is 50 mg once daily as usual starting dose which can be increased to 100 mg according to the patient's blood pressure response to the medicine. The usual dose for children is 0.7 mg/kg or 0.3 mg/lb once daily (up to 50 mg). The maximum dose for adult patients of Angizaar-50 is 100 mg once daily per day. Angizaar-50 is commonly used at the same time every day. This medicine is not known to be addictive or habit-forming.
This medicine is to be used for longer periods of time. Use of Angizaar-50 may be prescribed for the long-term to control the high blood pressure conditions. Angizaar-50 should be used as directed by the doctor even if you feel well, or even if you think that there is no need for you to use your medicine.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.

Talk to Your Doctor

Discuss with your doctor if your condition persists or worsens or if you develop new symptoms. Discuss with your doctor if swelling of the face, swelling of the lips, swelling of the throat, swelling of the tongue, low blood pressure, weight gain, swelling in feet, swelling in the hands, and swelling in the ankles. If you have issues with the health of your liver, The starting dose of 25 mg once daily is recommended in patients with abnormal liver function. Consult with your doctor before stopping the use of Angizaar-50.
Your doctor may prescribe a lower starting dose of this medicine to understand the impact on the body. Please follow your doctor's recommendations.

Use in Children

If you are giving Angizaar-50 Tablet to a child, be sure to use a product that is for use in children. Use the child's weight or age to find the right dose from the product package or medicine label. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
Medicines may be recommended for uses other than those listed in the medicine guide. You should not use Angizaar-50 Tablet for conditions or symptoms for which it was not prescribed. Do not give Angizaar-50 Tablet to other people, even if they have the same conditions or symptoms that you have. The use of this medicine without the advice of a doctor may cause harm.

Storage

Follow storage instructions on the product package if available. Store Angizaar-50 Tablet at 15°C to 30°C (59°F to 86°F), away from moisture, and away from light. Store this medicine away from children and pets.

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How to take Angizaar-50

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Angizaar-50 depends on the following factors:
  • patient's age
  • patient's weight
  • patient's health
  • the health of the patient's kidneys
  • medicines recommended by your doctor
  • any other medicines in use
  • herbal supplements consumed
  • response to treatment

Angizaar-50 Dosage

Dosage for high blood pressure

Adult
  • Recommended: 50-100 mg once daily as per patient's response to medicine
  • Initial: 50 mg once daily
  • Maximum: 100 mg once daily in morning
Children (children more than 6 years)
  • Initial: 0.7 mg/kg (0.3 mg/lb) once daily
  • Maximum: 50 mg once daily
Children (children (weight greater than 20 kg or 44.1 lb and less than 50 kg or 110.2 lb))
  • Recommended: 25 mg once daily
  • Maximum: 50 mg once daily
Children (children (weight more than 50 kg or 110.2 lb))
  • Recommended: 50 mg once daily
  • Maximum: 100 mg once daily

Dosage for high bp with enlarged heart

Adult
  • Recommended: 50-100 mg once daily depending upon the patient's response to medicine
  • Initial: 50 mg once daily
  • Maximum: 100 mg once daily

Dosage for high bp with protein in urine

Adult
  • Recommended: 50-100 mg once daily based on the patient's blood pressure conditions
  • Initial: 50 mg once daily
  • Maximum: 100 mg once daily

Dosage for diabetic patients with kidney disease

Adult
  • Recommended: 50-100 mg once daily based on the patient's blood pressure conditions
  • Initial: 50 mg once daily
  • Maximum: 100 mg once daily

Dosage for patients with loss of blood volume

Adult
  • Initial: 25 mg once daily

Minimum Age

6 years

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 25 mg, 50 mg, and 100 mg
Suspension
Strength: 2.5 mg/mL
Tablet, film coated
Strength: 25 mg, 50 mg, and 100 mg

Missed Dose

Take the missed dose as soon as you remember. Do not take a second dose to make up for the dose that you may have missed. Just continue with the next dose.

Overdose

What to do if you overdose on Angizaar-50?
If you have taken more than the recommended dose of Angizaar-50 and symptoms like low blood pressure occur, treat the symptoms and provide supportive measures. The toxic effect can be reduced by taking activated charcoal. Activated Charcoal is a form of carbon that has small, low-volume pores. These pores help trap chemicals as in the case of poisoning.
Symptoms of an overdose of Angizaar-50
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Angizaar-50 Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Angizaar-50

Before you use Angizaar-50, tell your doctor of your medical and health history including the following:
  • diabetes
  • heart failure
  • kidney problems
  • liver problems
  • severe conditions of vomiting
  • severe diarrhea
Before you use Angizaar-50 Tablet, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
The use of this medicine may change red blood cells count (hemoglobin) and the ratio of the volume of red blood cells to the total volume of blood (hematocrit). A small decrease in hemoglobin and hematocrit value has been reported in patients while using this medicine.
The use of this medicine may change blood urea nitrogen. A minor increase in blood urea nitrogen level has been seen in patients while using this medicine.
The use of Angizaar-50 Tablet may change electrolyte level.
The use of this medicine may change blood pressure.
The use of Angizaar-50 Tablet may change blood creatinine levels. A minor increase in blood creatinine level has been reported in patients while using this medicine.

Dizziness

Angizaar-50 Tablet can make you feel sleepy. Be careful when using any machinery, driving a vehicle, or doing any other activity that needs you to be fully alert. The consumption of alcohol with Angizaar-50 Tablet can worsen the sleepiness.

Use in Pregnancy

The use of Angizaar-50 is known to be not safe for use in pregnant women. If you are planning to become pregnant or are currently pregnant, you should discuss with your doctor the potential impact of this medicine on the baby before you start to using it. The use of this medicine in pregnant women can cause injury to the developing fetus and is possibly fatal to the unborn baby.

Use while Breastfeeding

The use of Angizaar-50 Tablet is not safe for use in women who are breastfeeding. If you are breastfeeding a baby, discuss with your doctor if you should either discontinue breastfeeding or stop using this medicine while breastfeeding. It is unknown that if this medicine may pass into breast milk or not.

Use while Conceiving

Consult with your doctor on the use of Angizaar-50, if you are trying to conceive.

Increased Risks

This medicine may increase your sensitivity to sunlight. If this happens, use a sunscreen and cover your skin when you are outdoors. Limit your time in the sun.

What precautions should be taken during Pregnancy and Nursing, and administering Angizaar-50 to Children or the Older Adults?

Pregnant Women

Contraindication
Warning: The use of this medicine during the second and third trimester of pregnancy reduces the functioning of kidneys and may increase the risk of abnormal growth of lungs and skeletal bone defects in the fetus.

Breastfeeding

Contraindicated or Not Recommended
Warning: Choose an alternative method of breastfeeding rather than using Angizaar-50.

Younger Adults Population

Possibly safe
Warning: This medicine is not recommended in children of age less than 6 years or in children with abnormal functioning of kidney.

Older Adults Population

Possibly safe
Warning: As no differences are found in efficacy and safety data for elderly patients, so this medicine can safely be given to elderly patients more than 75 years.

Angizaar-50 Side-effects

The following side-effects may commonly occur when using Angizaar-50 Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use of Angizaar-50 Tablet may cause the following side-effects:
The following severe side-effects may also occur when using Angizaar-50 Tablet:
  • Symptoms: low levels of thrombocytes
  • Metabolic and nutrition disorders
    Symptoms: low sodium level in the blood
  • Skin disorders
    Symptoms: increased sensitivity to light
  • Stomach and intestinal disorders
    Symptoms: constipation
  • Immune system disorders
    Symptoms: life-threatening allergic reaction (anaphylaxis), swelling of the lower layer of skin inflammation of the blood vessels (vasculitis)
  • Symptoms: depression
  • Liver disorders
    Symptoms: inflammation of the liver inflammation of the pancreas
  • Heart disorders
Your doctor has prescribed Angizaar-50 Tablet because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Angizaar-50 Tablet.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Angizaar-50 by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
  • swelling of the face
  • swelling of the larynx and glottis
  • swelling of the lips
  • swelling of the throat
  • swelling of the tongue
You should discontinue the use of this medicine and get emergency treatment as soon as possible.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Pregnant Women

Women during second and third trimester of pregnancy are at an increased risk when using this medicine. Use of Angizaar-50 may cause side effects to an unborn baby which includes an incomplete development of the skull, failure of the kidneys to produce urine, low blood pressure, kidney failure, and can be possibly fatal. Discontinue the use of Angizaar-50 as soon as pregnancy is detected.

Decreased Blood Volume And Salt Level

Such patients may have a decrease in blood pressure while using Angizaar-50. A low dose is recommended before starting the therapy with Angizaar-50.

Worsening of the Functioning of Kidneys

Patients using Angizaar-50 are at an increased risk of kidney failure due to obstruction in the activity of the renin-angiotensin system and diuretics which helps to control the high blood pressure conditions. Consider proper monitoring or discontinuation of the therapy in patients who develop a decrease in the functioning of kidneys while using Angizaar-50.

Increased Potassium Levels in the Blood (Hyperkalemia)

Hyperkalemic patients are at an increased when using this medicine. Proper monitoring of potassium levels in the blood is achieved by discontinuation or lowering the dose of Angizaar-50 in such patients.

Abnormal Functioning of the Liver

Such patients may have increased levels of Angizaar-50 in the blood. A low dose of Angizaar-50 should be given to patients with a history of abnormal liver functioning.

Heart And Brain Diseases

These patients may have an increased risk of heart attack or stroke.

Heart Failure

Patients with heart failure are at an increased risk when using this medicine. These patients may have an increased risk of severe low blood pressure and abnormal functioning of the kidney. Take necessary precautions while using this medicine in these patients.

Blood Pressure Lowering Agents

Such patients may have an increased risk of high potassium levels in blood, low blood pressure and kidney failure. The combined therapy of these agents with Angizaar-50 is not recommended as it may lead to blockage of the renin-angiotensin-aldosterone system.

Electrolyte Imbalance

Patients with abnormal functioning of the kidney with or without diabetes are at an increased risk when using this medicine. Such patients may have an increased risk of high potassium levels in the blood in diabetic patients with kidney disease. Careful monitoring of potassium levels in the blood and kidney parameter (creatinine clearance value) is required in patients with heart failure.

Abnormally Thickened Heart Muscles

Patients with narrowing of large blood vessels of heart or abnormally thickened heart muscles are at increased risk while usimg this medicine. Angizaar-50 should be taken with caution in such patients.

Increased Hormonal Levels (Aldosterone)

Children with abnormal functioning of the kidney are at an increased risk when using this medicine. Such patients will not respond adequately to blood pressure lowering effects. Use of Angizaar-50 is not recommended in these patients.

Interactions with Angizaar-50

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Angizaar-50 Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Drugs Increasing Blood Potassium Level

Angizaar-50 Tablet may interact with drugs which increase blood potassium level. The use of Angizaar-50 with these drugs (for example potassium-sparing diuretics, amiloride, triamterene, spironolactone, heparin, potassium supplements or salt substitutes) may raise the levels of potassium in the blood. The combined use of Angizaar-50 with these drugs is not recommended. Proper monitoring of potassium levels in the blood is required.

Antimanic Agent

There may be an interaction of Angizaar-50 with Antimanic Agent such as lithium, which is used to treat depression. The combined use of Angizaar-50 with lithium may lead to harmful effects and increased levels of lithium in blood. The blood lithium level should be monitored when both the medicines used in combination.

Nonsteroidal Anti-Inflammatory Drugs

Angizaar-50 Tablet interacts with nonsteroidal anti-inflammatory drugs, which are used to reduce pain, fever, and inflammation. The patients using Angizaar-50 and non-steroidal anti-inflammatory drugs may see an increased risk of worsening of functioning of kidney, kidney failure, increased potassium levels in the blood, and blood pressure lowering effects. The functioning of the kidney should be monitored periodically in patients receiving Angizaar-50 and NSAID therapy.

Cytochrome P450 2C9 Enzyme Inhibitors

Special instructions need to be followed while taking this medicine along with cytochrome P450 2C9 enzyme inhibitors (for example, rifampicin) which are used to treat bacterial infections. The combined use of Angizaar-50 with rifampicin may lead to decreased levels of an active metabolite of Angizaar-50 in the blood.

Other Renin-Angiotensin System (RAS) Inhibitors

Your doctor's guidelines may need to be followed while taking this medicine along with other renin-angiotensin system (RAS) inhibitors, which are used to treat high blood pressure. The use of Angizaar-50 with other renin-angiotensin system inhibitors (angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, lisinopril or aliskiren) may lead to an increased risk of low blood pressure, fainting, increased potassium level in the blood, and acute kidney failure. Avoid the combined use of Angizaar-50 with another renin-angiotensin system (RAS) inhibitors in patients with abnormal functioning of the kidneys.

Antihypertensive Agents

Angizaar-50 Tablet may interact with other antihypertensive agents, anti-depressants, anti-psychotics, central nervous system depressants and anti-cancer drugs (tricyclic antidepressants, baclofene and amifostine) which are used to treat high blood pressure, depression, anxiety, muscle spasms and cancer. When Angizaar-50 is used with other antihypertensive agents may increase the risk of low blood pressure.

Potassium Sparing Diuretics And Heparin

There may be an interaction of Angizaar-50 with Potassium Sparing Diuretics (amiloride, triamterene, spironolactone) and Heparin, which are used to treat high blood pressure and prevents blood clotting. Use of Angizaar-50 with potassium-sparing diuretics may increase the level of potassium in the blood. The combined use of both the medicines is not recommended.

Interactions of Angizaar-50 by Severity

Severe

The following medicines are usually not to be taken together without consulting with your doctor or pharmacist.

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Angizaar-50 be not used?

Allergy to Angizaar-50 or Its Components

This medicine should not be used in patients who are allergic to this medicine or its components. These patients may have the following symptoms if they use this medicine:
  • swelling of the face
  • swelling of the lips
  • swelling of the tongue
  • swelling of the throat

Use of Aliskiren in Diabetic Patients

This medicine is not recommended in diabetic patients who are using aliskiren. Such patients may see an increased risk of stroke and heart failure. These patients may have the following symptoms if they use this medicine:

Severe Abnormal Functioning of the Liver

This medicine should not be used in these patients.

Second And Third Trimester of Pregnancy

This medicine should not be used in women during second and third trimester of pregnancy. This medicine may lead to increased congenital (birth) defects such as abnormal growth development in the fetus. These patients may have the following symptoms if they use this medicine:

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Angizaar-50 is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Angizaar-50 Tablet .
High Blood Pressure
Stroke
Diabetic Kidney Disease
Heart Diseases

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