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Why it's used

Unimox 500 Capsule is used to treat certain bacterial infections. These include bacterial infections of the ear, nose, or throat, reproductive tract infections or urinary system infections such as UTI, and skin or respiratory system infections including pneumonia. Unimox 500 is also used to treat bacterial infections in other parts of the body including in teeth from a dental abscess, in the joints, in the blood or heart, and bacterial infections in the brain or the spinal cord caused by bacterial meningitis. Unimox 500 is also used to treat tick-borne bacterial infections, also called as, Lyme disease. It is a prescription medicine. This medicine works by preventing growth of bacteria in the body.
Unimox 500 Capsule may also be taken in combination with other medicines to treat certain conditions as recommended by the doctor. Unimox 500 Capsule is used together with Clarithromycin, or Lansoprazole to treat infections caused by bacteria (Helicobacter pylori) and duodenal ulcer disease. This combination is used to reduce bacterial resistance and to maintain the effectiveness of Unimox 500. Unimox 500 is also used alone with lansoprazole in the patient cannot use clarithromycin.
When not to use
Unimox 500 Capsule will not work against viral infections. Also, this medicine should be used only to treat infections that are proven to be caued by bacteria or strongly suspected to be caused by bacteria.
Penicillin-class Antibacterial
Unimox 500 belongs to a class of medicines called Penicillin-class Antibacterial. Penicillin are a group of antibiotics that are used to treat and prevent different type of bacterial infections.

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How to use

Read the medicine guide provided by your pharmacist, your doctor, or the medicine company. If you have any questions related to Unimox 500, ask your doctor or pharmacist. Use Unimox 500 Capsule as per the instructions provided by your doctor.
Unimox 500 is used with or without food.

Typical Dosage

The typical dose of Unimox 500 for adults is 250-500 mg every 8 hours or 500-875 mg in 12 hours depending on the severity of the infection. The usual dose for children is 20-40 mg/kg/day (9.09-18.18 mg/lb/day) in a divided dose every 8 hours or 25-45 mg/kg/day (11.36-20.45 mg/lb/day) in a divided dose every 12 hours depending on the patients condition. This medicine is generally used for a period of 2-3 days till after the symptoms of the infection disappear for bacterial infections. This medicine is not known to be addictive or habit-forming.
This medicine should be used on an as-needed basis. Unimox 500 should be used as directed by the doctor even if you feel well, or even if you think that there is no need for you to use your medicine.
If you are using the chewable tablet form of this medicine, make sure you chew the medicine before you swallow it.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.
When using this medicine in the injection form, it should be given through veins. The injection is injected or infused slowly into the veins throughout 3-4 minutes. Infusion in the veins should be given throughout 30-60 minutes. Injection in the muscles should be given in those patients where injection in the veins is not possible. Add water for the injection and shake vigorously. For vein infusion preparation, add solution for vein injection to in-line burette or in a minibag over 30-60 minutes. Alternatively the vein injection solution may be transferred from the infusion bag into the vial by using a device, and then drawn back into the bag after dissolution.

Talk to Your Doctor

Discuss with your doctor if you develop new symptoms. Discuss with your doctor if watery and bloody stools, stomach cramps, and fever. If you have any kidney disease, a low dose should be taken up to 250-500 mg every 24 hours. It depends on the severity of the infection.

Use in Children

If you are giving Unimox 500 Capsule to a child, be sure to use a product that is for use in children. Use the child's weight or age to find the right dose from the product package or medicine label. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Lab Tests

Your doctor may request that specific lab tests be performed before you start using Unimox 500 Capsule. Your doctor may ask you to undergo Antibiotic Susceptibility test. This test is required to determine the specific bacterial infection.
Medicines may be recommended for uses other than those listed in the medicine guide. You should not use Unimox 500 Capsule for conditions or symptoms for which it was not prescribed. Do not give Unimox 500 Capsule to other people, even if they have the same conditions or symptoms that you have. The use of this medicine without the advice of a doctor may cause harm.

Storage

Follow storage instructions on the product package if available. Store Unimox 500 Capsule at or below 25°C (77° F), away from moisture, and away from light. Store this medicine away from children and pets.

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How to take Unimox 500

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Unimox 500 depends on the following factors:
  • patient's age
  • patient's weight
  • patient's health
  • the health of the patient's liver

Unimox 500 Dosage

Dosage for mild to moderate bacterial infections

Adult (weight more than or equal to 40 kg (88.2 lb))
  • Recommended: 250 mg every 8 hours or 500 mg every 12 hours orally

Dosage for severe infections of the ear, nose, and throat

Adult (weight more than or equal to 40 kg (88.2 lb))
  • Recommended: 500 mg every 8 hours or 875 mg every 12 hours orally and 750 mg - 2000 mg every 8 hours or 2000 mg every 12 hours (injection)

Dosage for mild to moderate infections of the skin

Adult (weight more than or equal to 40 kg (88.2 lb))
  • Recommended: 250 mg every 8 hours or 500 mg every 12 hours orally

Dosage for severe infections of the skin

Adult (weight more than or equal to 40 kg (88.2 lb))
  • Recommended: 500 mg every 8 hours or 875 every 12 hours orally

Dosage for mild to moderate genitourinary tract infection

Adult (weight more than or equal to 40 kg (88.2 lb))
  • Recommended: 250 mg every 8 hours or 500 mg every 12 hours orally

Dosage for severe genital and urinary tract infection

Adult (weight more than or equal to 40 kg (88.2 lb))
  • Recommended: 500 mg every 8 hours or 875 mg every 12 hours orally

Dosage for lower respiratory tract infection

Adult (weight more than or equal to 40 kg (88.2 lb))
  • Recommended: 500 mg every 8 hours or 875 mg every 12 hours orally and 750 mg to 2000 mg every 8 hours or 2000 mg every 12 hours (injection)
  • Maximum: 12000 mg/day (injection)

Dosage for artificial joint infections

Adult (weight greater than or equal to 40 kg (88.2 lb))
  • Recommended: 750 mg to 2000 mg every 8 hours or 2000 mg every 12 hours (injection)
  • Maximum: 12000 mg/day (injection)

Dosage for prevention of heart infection

Adult (weight greater than or equal to 40 kg (88.2 lb))
  • Recommended: 2000 mg single dose 30 to 60 minutes before the operation (injection)

Dosage for heart infection

Adult (weight greater than or equal to 40 kg (88.2 lb))
  • Recommended: 1000 mg to 2000 mg every 4 to 6 hours (injection)
  • Maximum: 12000 mg/day (injection)

Dosage for inflammation of the brain and spinal cord membrane

Adult (weight greater than or equal to 40 kg (88.2 lb))
  • Recommended: 1000 mg to 2000 mg every 4 to 6 hours (injection)
  • Maximum: 12000 mg/day (injection)

Dosage for tick-borne illness (Lyme disease)

Adult (weight greater than or equal to 40 kg (88.2 lb))
  • Recommended: 2000 mg every 8 hours in the late stage of the disease (injection)

Dosage for bacterial blood infection

Adult (weight greater than or equal to 40 kg (88.2 lb))
  • Recommended: 1000 mg to 2000 mg every 4 to 8 hours (injection)
  • Maximum: 12000 mg/day (injection)

Children and Older Adults

View dosage instructions for children and older adults from the dosage for Unimox 500 page.

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Capsule
Strength: 250 mg, 500 mg
Oral Suspension
Strength: 125 mg/5 mL, 200 mg/5 mL, 250 mg/5 mL, 400 mg/5 mL
Powder for Injection
Strength: 50 mg, 250 mg, 500 mg, 1000 mg
Tablet
Strength: 125 mg, 200 mg, 250 mg, 400 mg, 500 mg, 775 mg, 875 mg

Missed Dose

Talk to your doctor if you miss a dose of Unimox 500.

Overdose

What to do if you overdose on Unimox 500?
In case of overdosage, discontinue the medicine, treat the symptoms and provide supportive measures. Also, adequate fluid intake and increased urination should be maintained. Unimox 500 can be removed from the blood by artificial blood purifying technique (hemodialysis). The openness of the tube should be regularly checked in patients having a thin tube inserted into the bladder.
Symptoms of an overdose of Unimox 500
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Unimox 500 Capsule, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Unimox 500

Before you use Unimox 500, tell your doctor of your medical and health history including the following:
  • HIV
  • cancer of white blood cells
  • heart disease or history of heart failure
  • kidney related health problems
  • sore throat
  • urinary problem
  • viral fever (also called glandular fever)
Before you use Unimox 500 Capsule, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic to penicillin antibiotics, or cephalosporin.

Use in Pregnancy

Unimox 500 Capsule should be used in pregnancy only when required. No adequate and well-controlled studies of Unimox 500 have been done in pregnant women. It should be used during pregnancy only if needed.

Use while Breastfeeding

Consult with your doctor on the use of Unimox 500 during breastfeeding. This medicine can pass into breast milk and may affect the babies that cause diarrhea and fungal infection.

Impact on Fertility

Consult with your doctor on the use of Unimox 500 Capsule, if you are trying to conceive. There are no known effects on fertility when using this medicine. Its best to discuss with your doctor if you are having fertility related issues.

Seizures

Unimox 500 Capsule can make you feel sleepy. Be careful while driving, using machinery, or doing any other activity that needs you to be alert. The consumption of alcohol with Unimox 500 Capsule can make you feel more sleepy. Unimox 500 Capsule may cause seizures in some people. Discuss with your doctor if you perform activities where a loss of consciousness may cause you or others harm.

Side-effects in Older Patients

Unimox 500 Capsule may increase side-effects in older patients.

Unimox 500 Side-effects

The following side-effects may commonly occur when using Unimox 500 Capsule. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use of Unimox 500 Capsule may cause the following side-effects:
  • abnormally active
  • behavioral changes
  • black hairy tongue
  • dizziness
  • hives
  • itching of the skin
  • sleeplessness
  • sore mouth or tongue
  • tooth discoloration (brown, yellow, or gray staining)
  • yeast infection of mouth, skin and nails
The following severe side-effects may also occur when using Unimox 500 Capsule:
  • Severe skin reactions due to allergy (possibly fatal)
    If this happens, immediate emergency treatment with supportive measures should be given to the patient.
  • Blood disorders (prolongation of the bleeding time)
  • Kidney and urinary tract disorders
    Symptoms: cloudy urine
  • Brain disorders (possibly fatal)
    Symptoms: dizziness convulsions
  • Immune system disorders
    Symptoms: accumulation of fluid under the skin life-threatening allergic reaction
  • Diarrhea associated with bacteria Clostridium difficile (can be possibly fatal)
    Symptoms: diarrhea
    If this occurs, the ongoing antibiotic use may need to be discontinued. Also, suitable fluid and electrolytes, protein supplements, antibiotic treatment, and surgical evaluation should be given to such patients.
  • Liver dysfunction
  • Symptoms: hallucinations
  • Decrease in potassium level
Your doctor has prescribed Unimox 500 Capsule because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Unimox 500 Capsule.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Antibacterial Drugs

Patients using antibacterial drugs including Unimox 500 are at an increased risk. These patients may suffer from diarrhea associated with Clostridium difficile bacteria that can lead to severe inflammation of the colon. If this happens, stop using this medicine and take antibiotics, protein supplements or maintain the balance of body fluid and electrolyte. If necessary, surgical evaluation should be done.

Development of Drug Resistant Bacteria

Unimox 500 is not likely to provide benefit unless the patient uses it to treat a bacterial infection. Otherwise, the risk of developing drug-resistant bacteria is increased by the use of Unimox 500.

Viral Infection

Patients with viral infection (also called mononucleosis) caused by Epstein-Barr virus are at increased risk when using this medicine. These patients may suffer from skin rash. It is advised that Unimox 500 should not be used in these patients.

Birth Defect Called Phenylketonuria

Patients with increased phenylalanine levels in the body are at an increased risk when using chewable tablets of Unimox 500. The chewable tablets should not be used in these patients if it contains phenylalanine. The oral suspension of Unimox 500 can be used in these patients because it does not contain phenylalanine.

History of Brain and Spinal Cord Disorders

Patients using Unimox 500 in high doses and have a history of seizures, epilepsy, or brain and spinal cord disorders are at an increased risk. These patients may suffer from seizures.

Kidney Dysfunction

Patients with kidney dysfunction are at an increased risk when using this medicine. In such patients, the dose should be adjusted according to the condition.

Skin Reactions

Patients using Unimox 500 are at an increased risk of developing serious skin reactions. If this happens, stop using this medicine.

Lyme Disease

Patients with a bacterial infection caused by a tick bite (Lyme disease) are at an increased risk when using this medicine. These patients may suffer from allergic reactions called Jarisch-Herxheimer reaction.

Prolonged Therapy

Patients at prolonged therapy with Unimox 500 are at an increased risk. These patients may develop changes in blood count and increase in liver enzymes. In such patients, monitoring of blood cells production, kidney and liver function is required.

Blood Thinners

Patients using blood thinners are at an increased risk when using this medicine. In these patients, blood clotting time is increased. The dose adjustment of blood thinners is required.

Cloudy Urine

Patients with reduced urine output and bladder catheters are at an increased risk when using this medicine. These patients may suffer from cloudy urine. It is advised to maintain urinary output and adequate fluid intake to reduce the chances of cloudy urine. In patients with bladder catheters, a regular checkup is recommended.

Interactions with Unimox 500

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Unimox 500 Capsule. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Antigout Agents

Unimox 500 Capsule interacts with Antigout Agents such as allopurinol, which is used to treat gout. There is an increase in the incidence of rashes in patients receiving these drugs together.

Oral Anticoagulants

There may be an interaction of Unimox 500 with Oral Anticoagulants, which help by preventing the formation of blood clot. When Unimox 500 is used with oral anticoagulants, increase in prothrombin time has been reported which results in the increase in the bleeding time. The patient should be monitored when this medicine is taken in combination with anticoagulants. The adjustment in the dose of oral anticoagulants may also be necessary.

Uricosuric Agent

Unimox 500 Capsule may interact with Uricosuric Agent such as probenecid, which is used to treat gout. When Unimox 500 is used with probenecid, it may increase the level of Unimox 500 in the blood. The combined use of probenecid with this medicine is not recommended.
Your doctor's guidelines may need to be followed while taking this medicine along with antibacterials, which are used to treat bacterial infection. The antibacterials such as macrolides, tetracyclines sulfonamides and chloramphenicol may interfere with the effectiveness of Unimox 500.

Oral Contraceptives

Special instructions need to be followed while taking this medicine along with Oral Contraceptives, which are used to prevent pregnancy. When Unimox 500 is used with oral contraceptives, it may effect microorganisms present in the digestive tract. This results in decreased estrogen reabsorption and thus reduces the effectiveness of oral contraceptives.

Sex Steroids

Special instructions need to be followed while taking this medicine along with Sex steroids such as oestriol, which is a female sex hormone. When Unimox 500 is taken by pregnant women, a decrease in the level of estrogens in the blood has been noted.

Chemical Reagents

Unimox 500 Capsule interacts with Chemical Reagents such as Benedict’s solution or Fehling’s solution. The presence of high levels of Unimox 500 in the urine may results in false-positive reactions while performing glucose testing. Glucose tests based on enzymatic glucose oxidase reactions are recommended.

Antimetabolites

There may be an interaction of Unimox 500 with Antimetabolites such as methotrexate, which is mainly used to treat cancer. Unimox 500 may reduce the excretion of methotrexate which results in its increased level in the blood.

Tetracyclines

Unimox 500 Capsule may interact with Tetracyclines, which are used to treat infections. Tetracyclines and other antibacterial drugs may interfere with the effectiveness of Unimox 500.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Unimox 500 is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Unimox 500 Capsule .
Bacterial Infections
Urinary Tract Infections
Pneumonia
Lyme Disease

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