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Why it's used

Kadiflam Tablet is a prescription medicine that is used to relieve pain and inflammatory conditions of joints. This medicine works by restricting the functions of natural enzymes (Cyclooxygenase -1 and Cyclooxygenase-2) in the body which prevents the release of inflammatory agents. Kadiflam Tablet is also used to relieve pain and inflammatory conditions caused by injuries and diseases affecting body movements, and to relieve pain and inflammation associated with other painful conditions such as fracture, trauma, low back pain, dislocations, dental and other minor operation, tearing or stretching of tissue that connects bones and joints, or pulled muscle.
Kadiflam Tablet may also be used along with other medicines in the treatment of certain conditions as recommended by the doctor. It is used with opioid analgesics for the management of mild to severe pain.
When not to use
Kadiflam Tablet cannot be used to treat pain that occurs after or before heart bypass surgery.
Nonsteroidal Anti-inflammatory Drugs
Kadiflam belongs to the Nonsteroidal Anti-inflammatory Drugs class of medicines. Nonsteroidal anti-inflammatory drugs, also called as NSAIDs, help reduce fever, decrease pain, and prevent clotting of blood. NSAIDs also reduce inflammation in the body when used in higher doses.

How to use

Read the medicine guide provided by your pharmacist, your doctor, or the medicine company. If you have any questions related to Kadiflam, ask your doctor or pharmacist. Use Kadiflam Tablet as per the instructions provided by your doctor.
Kadiflam Tablet is a pain reliever. Pain relievers work the best if used as soon as you feel any pain. They may not work as well if they are delayed until the pain has worsened.
Kadiflam is used with or after food when taken by mouth.
The typical dose of Kadiflam for adults is 100-200 mg in one day. This medicine is not known to be addictive or habit-forming.
This medicine should be used on an as-needed basis.
Discuss with your doctor if you develop new symptoms.
Your doctor may prescribe a lower starting dose of this medicine to understand the impact on the body. Please follow your doctor's recommendations. A lower dose of this medicine may be recommended to reduce the risk of side-effects.
The safety and effectiveness of using Kadiflam Tablet in children has not been established.
To decrease the possibility of side-effects, you might be recommended to use the extended-release form of this medicine by your dcotor. The extended-release medicine helps in maintaining a steady level of the medicine in your body for a longer period of time. Do not crush or chew the medicine, unless indicated on the package or by your doctor.
If using the delayed-release form of this medicine, do not crush or chew the medicine, unless indicated on the package. Crushing or chewing of the medicine can result in unpleasant taste resulting in patients not following the medicine schedule. Crushing or chewing can also release all of the medicine at once, resulting in a decrease of effectiveness and a possible increase in side-effects.
Kadiflam injection is intended to use in the veins only. Inject over 15 seconds every 6 hours as desired.
Avoid consuming alcohol together with Kadiflam.
Medicines may be recommended for uses other than those listed in the medicine guide. You should not use Kadiflam Tablet for conditions or symptoms for which it was not prescribed. Do not give Kadiflam Tablet to other people, even if they have the same conditions or symptoms that you have. The use of this medicine without the advice of a doctor may cause harm.
Wash your hands thoroughly after touching or handling Kadiflam.
Follow storage instructions on the product package if available. Store Kadiflam Tablet at 20-25°C (68 to 77°F) for injection and at 15-30°C (59-86°F) for the tablet, away from moisture, and away from light. Store this medicine away from children and pets.

How to take Kadiflam

Your dose and how often you take Kadiflam will depend on the following factors:
  • age
  • weight
  • patient's health
  • response to the medicine

Kadiflam Dosage

Dosage for painful and stiff joints (osteoarthritis)

Adult
  • Recommended: 100-150 mg/day in divided doses (50 mg twice or thrice a day or 75 mg twice a day)

Dosage for swollen and painful joints (rheumatoid arthritis)

Adult
  • Recommended: 150-200 mg/day in divided doses (50 mg three or four times a day or 75 mg twice a day)

Dosage for long-term inflammation of the joints of the spine (ankylosing spondylitis)

Adult
  • Recommended: 100-125 mg/day, taken as 25 mg four times a day, with an extra dose of 25-mg at bedtime if necessary

Minimum Age

18 years

Forms

Tablet
Strength: 25 mg, 50 mg, 75 mg
Injection
Strength: 37.5 mg/mL

Special Instructions

Acute pain
A dose of 37.5 mg is given through an injection in the veins over 15 seconds after every 6 hours as needed. Do not exceed the dose more than 150 mg/day.

Overdose

What to do if you overdose on Kadiflam?
If you have taken more than the recommended dose of Kadiflam, an activated charcoal (60 to 100 g in adults, 1 to 2 g/kg in children) may be given. Passing the contents of the bowels out of the body (osmotic cathartic) within 4 hours of ingestion with large overdose (5 to 10 times the usual dose) should be recommended.
Symptoms of an overdose of Kadiflam
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Kadiflam Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Kadiflam

Before you use Kadiflam Tablet, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic to aspirin, or other NSAIDs.
Before you use Kadiflam, tell your doctor of your medical history including asthma, hives, allergic-type reactions, ulcer disease, stomach and intestinal bleeding, heart disease, or heart surgery. Patients with asthma, hives, allergic-type reactions and ulcer disease may experience severe and rarely fatal allergic reactions. Patients with stomach and intestinal bleeding may experience severe stomach bleeding on using this medicine. Patients with a history of heart disease are at an increased risk of thrombotic heart disease, heart attack, and stroke. Before having any surgery when using Kadiflam, tell your doctor and dentist about all the medicinal products you use including prescription and non-prescription medicines, and any herbal supplements.
The use of this medicine may change transaminases (alanine transaminase and aspartate transaminase). Kadiflam increases transaminases levels in the liver which may lead to severe liver reactions. Monitor transaminases within 4 to 8 weeks after taking Kadiflam.
The use of Kadiflam Tablet may change blood pressure. Using Kadiflam may lead to occurrence or worsening of high blood pressure. Blood pressure monitoring is required in the starting and during the course of therapy.
The use of this medicine may change hemoglobin. Blood deficiency (also known as anaemia) can occur in patients using this medicine. Check hemoglobin levels of patients who show any signs and symptoms of anemia.
The use of this medicine may change Complete blood count. Bleeding can occur in patients taking Kadiflam and monitor signs and symptoms of bleeding. Check complete blood count in patients on long-term treatment with Kadiflam.
The use of Kadiflam Tablet may change bleeding time. Patients with bleeding disorders or taking anticoagulants may experience increased bleeding time when using Kadiflam. Such patients should be monitored for platelet function.
Limit the consumption of alcohol with Kadiflam Tablet. Drinking alcohol may cause increased risk of stomach and intestinal bleeding.
Kadiflam Tablet is not safe for use in pregnant women. If you are pregnant or planning to become pregnant, you should discuss the impact this medicine may have on the baby before you start to use this medicine. This medicine may cause harm to an unborn baby such as heart dysfunction (also known as premature closure of the ductus arteriosus). Kadiflam Tablet belongs to the NSAID class of medicines. NSAIDs should not be taken after 29 weeks of pregnancy as these medicines may cause serious harm to the unborn baby. Kadiflam Tablet should be used while breastfeeding only when required. It is not known whether this medicine passes into breast milk. This medicine should be used during breastfeeding only after considering the importance of the drug to the mother. Kadiflam Tablet may impact fertility in women. If you are trying to conceive, discuss with your doctor on the use of this medicine. Use of Kadiflam may decrease the conceiving abilities in women planning to become pregnant. Therefore, Kadiflam should be discontinued in women having difficulties in conceiving or who are receiving infertility treatment.
Kadiflam Tablet can make you feel sleepy. Be careful while driving, using machinery, or doing any other activity that needs you to be alert. The consumption of alcohol with Kadiflam Tablet can make you feel more sleepy. Kadiflam Tablet may cause seizures in some people. Discuss with your doctor if you perform activities where a loss of consciousness may cause you or others harm.
This medicine can cause stomach bleeding. The use of alcohol/tobacco with Kadiflam may increase your stomach bleeding risk. If you drink alcohol or smoke regularly, please discuss with your doctor. This medicine may increase your sensitivity to sunlight. If this happens, limit your time outdoors and do not tan to prevent sunburns. Cover your skin when you are outdoors or use a sunscreen. In case you get a sunburn, consult with your doctor.
Long-term use of this medicine may lead to kidney disorder (Renal Papillary Necrosis), kidney damage, heart attack, stroke, ulcers, and stomach and intestinal bleeding.

Kadiflam Side-effects

The following side-effects may commonly occur when using Kadiflam Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in older patients on the use of Kadiflam Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:
  • kidney insufficiency
Rarely, the use of Kadiflam Tablet may cause the following side-effects:
The following severe side-effects may also occur when using Kadiflam Tablet:
  • heart disorder such as stroke and heart attack (possibly fatal)
    The patient should get medical advice when experiencing such signs and symptoms.
  • serious skin adverse disorders such as redness and peeling of the skin (exfoliative dermatitis) and severe skin reaction (possibly fatal)
    Symptoms: skin rash, blisters, fever, itching, skin discoloration and hives
    Discontinue the use of the drug at the first appearance of skin rash or any other signs of allergy.
  • gastrointestinal disorders (possibly fatal)
    Symptoms: stomach and intestinal bleeding, ulceration, and ruptured lining of the small intestine, stomach, or large intestine, diarrhea, dry mouth, indigestion, inflammation of the gastrointestinal tract (gastroenteritis), decreased appetite, nausea, rectal hemorrhage and swelling and sores inside the mouth
    The medicine should be discontinued. Monitor the patients for signs or symptoms of gastrointestinal bleeding
  • severe liver reactions, including the decrease in liver size (fulminant hepatitis) with and without jaundice, jaundice and liver failure ((possibly) fatal and liver transplantation)
    Symptoms: increased number of eosinophiles (eosinophilia), rash, abdominal pain, diarrhea and dark urine
    If the symptoms persist or worsen, the medicine should be discontinued.
  • metabolic and nutritional disorders
    Symptoms: creatinine increased
  • nervous system disorders
    Symptoms: depression, dizziness, drowsiness, lethargy and burning sensation in the parts of the body
  • respiratory system disorder (possibly fatal and leads to bronchospasm)
    Symptoms: asthma, shortness of breath (dyspnea), sudden contraction of the larynx (laryngismus), inflammation of the larynx (laryngitis) and inflammation of the pharynx (pharyngitis)
  • musculoskeletal disorders
    Symptoms: leg cramps and muscle pain
  • sensory organ disorders
    Symptoms: abnormal vision, blurred vision, cataract, ear pain, eye disorder, eye pain, changes in taste and loss of hearing
Your doctor has prescribed this medicine because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious cases of side-effects. This page does not contain a complete list of all possible side-effects.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

History of stomach ulcers

Patients with the history of stomach ulcer or stomach and intestine disease are at an increased risk when using this medicine. These patients are at higher risk for developing bleeding in the stomach or intestine when using this medicine. Patients should start with the lowest dose for the shortest duration to decrease the risk of bleeding.

Patients with open skin wounds, infections, inflammations, or redness or peeling of the skin (exfoliative dermatitis)

Such patients are at an increased risk when using this medicine. This may affect absorption and tolerability of the Kadiflam. It can cause serious skin adverse events such as severe skin reaction, and redness or peeling of the skin (exfoliative dermatitis). Patients should discontinue the medicine at the first appearance of skin rash.

Use in pregnant or breastfeeding women

Pregnant women is at an increased risk when using this medicine. This medicine should not be used by pregnant women.

Patients with aspirin-sensitive asthma or patients without prior exposure to Kadiflam

Patients with aspirin-sensitive asthma or patients without prior exposure to Kadiflam are at an increased risk when using this medicine. Severe or life-threatening allergic reaction (anaphylactoid reactions) may occur. Use this medicine with caution in patients with existing asthma.

Patients undergoing diuretics and ACE-inhibitors therapy

Patients taking diuretics and ACE-inhibitors therapy are at an increased risk when using this medicine. Long-term use of Kadiflam may result in damaged kidney cells and other kidney injuries. Patients should be cautious while taking this medicine.

Abnormal functioning of kidneys, heart failure and liver dysfunction

Patients with abnormal functioning of kidneys, heart failure and liver dysfunction are at an increased risk when using this medicine. Long-term use of Kadiflam may result in damaged kidney cells and other kidney injuries. Patients should be cautious while taking this medicine.

Elderly patients

Elderly patients are at an increased risk when using this medicine. Long-term use of Kadiflam may result in damaged kidney cells and other kidney injuries. Patients should be cautious while taking this medicine.

Patients undergoing Kadiflam therapy

Patients taking Kadiflam are at an increased risk when using this medicine. Elevation of transaminases, high blood pressure, heart disease and bleeding may occur. Long-term use of Kadiflam can result in damaged kidney cells and other kidney injuries. The medicine should be discontinued immediately if increased transaminases or blood pressure persist or worsen.

Stomach and intestinal adverse events

Elderly patients, combined use of oral corticosteroids or anticoagulants and Kadiflam, patients who are on longer duration of NSAID therapy, alcohol use, smoking, have poor general health status, and older age are at an increased risk for serious stomach and intestinal events such as bleeding, ulceration and perforation. Patients should use the lowest effective dose for the shortest duration to reduce the risk of stomach or intestinal bleeding.

Use for heart disease

Patients with heart diseases such as thrombotic heart events, heart attack, and stroke may be at an increased risk. It may cause an increased risk of serious thrombotic heart events, heart attack, and stroke, which can be fatal. Patients should know about the signs or symptoms of serious heart disease and measures to take if they occur. Treatment should be started with the lowest effective dose for the shortest duration to minimize the risk of serious heart disease.

Topical use of Kadiflam

Patients using Kadiflam topically are at an increased risk when using this medicine. These patients are at an increased risk of irritation in the eyes. Such patients should wash their eyes and consult the doctor if irritation persists for more than one hour.

Undergoing corticosteroid therapy

Patients taking corticosteroid therapy are at an increased risk when using this medicine. These patients are at an increased risk of corticosteroid-induced illness after sudden discontinuation or substitution of corticosteroids with Kadiflam. Patients should discontinue corticosteroids slowly.

Patients with coagulation disorders

Patients with coagulation disorders are at an increased risk when using this medicine. These patients may experience prolonged bleeding when using Kadiflam. Careful monitoring should be done of the patients who are affected by the change in the platelet function.

Patients with non-infectious and painful conditions

Patients with non-infectious and painful conditions are at an increased risk when using this medicine. Using Kadiflam in these patients may reduce the use of diagnostic signs such as fever and inflammation.

Exposure to sun

Patients with sun exposure are at an increased risk when using this medicine. These patients are at an increased risk of ultraviolet light-induced skin cancer. Such patients should avoid exposure to sunlight.

Interactions with Kadiflam

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Your doctor's guidelines may need to be followed while taking this medicine along with lithium, which is used to treat mental disorders. Kadiflam increases the level of lithium in the blood. Patients should be observed for the signs of harmful effects due to the increased amount of lithium in the body.
Kadiflam Tablet interacts with Antihypertensive agents (beta-blockers, angiotensin converting enzyme (ACE) inhibitors), which are used to treat high blood pressure and heart failure. Kadiflam decreases the blood pressure lowering effect of antihypertensive drugs. Precaution should be taken in patients using Kadiflam with antihypertensives. The blood pressure should be regularly monitored in elderly patients. Patients who are at an increased risk of kidney failure should be monitored for the functioning of kidneys and should be properly hydrated.
There may be an interaction of Kadiflam with anticoagulants (warfarin and NSAIDs) and antiplatelets, which are used to prevent the blood clot. When Kadiflam is used with anticoagulants and antiplatelets, it increases the risk of stomach and intestinal bleeding. Patients should be cautious when taking both medicines together. Closely monitor such patients if required.
Kadiflam Tablet may interact with aspirin, which is used to treat pain, fever, or inflammation. When Kadiflam is used with aspirin, it potentially increases the undesired harmful effects. Patients should not take both medicines together.
Special instructions need to be followed while taking this medicine along with diuretics (furosemide and thiazides), which are used to treat heart failure and high blood pressure. Kadiflam may reduce the sodium excretion (natriuretic) effect of furosemide and thiazides in the urine. When Kadiflam is used with diuretics, patients should be observed for the signs of kidney failure to assure the ability for the production of urine.
Your doctor's guidelines may need to be followed while taking this medicine along with voriconazole, which is used to treat fungal infections. When Kadiflam is used with voriconazole, it may lead to undesirable effects of Kadiflam. The patient should be cautious when using Kadiflam with voriconazole. Also, the dose adjustment is recommended in such patients.
Kadiflam Tablet interacts with topical treatments (sunscreen, insect repellant, lotion, moisturizer and cosmetics). Before any topical treatment to the same surface treated with Kadiflam, patients should wait until the treated area gets completely dry.
Special instructions need to be followed while taking this medicine along with digoxin, which is used to treat heart failure. Kadiflam increases the level of digoxin in the blood. When Kadiflam is used with digoxin, it is recommended to monitor digoxin levels in the blood.
There may be an interaction of Kadiflam with cyclosporine, which is used to prevent organ rejection of the heart, kidney, and liver. When Kadiflam is used with cyclosporine, it may increase the cyclosporin induced kidney damage. Patients should take necessary precautions while taking cyclosporin in combination with Kadiflam. Also, a lower dose of cyclosporin is recommended in such case.
Kadiflam Tablet may interact with methotrexate, which is used to treat breast cancer and neck cancer. Kadiflam restricts the accumulation of methotrexate in kidneys, which may lead to harmful effects of methotrexate. Patients should be cautious when using both medicines together.
Kadiflam Tablet may interact with rifampin, which is used to treat bacterial infections. When Kadiflam is used with rifampin, it may lead to decreased effectiveness of Kadiflam. The patient should be cautious when using Kadiflam with rifampin. Also, the dose adjustment is recommended in such patients.
Your doctor's guidelines may need to be followed while taking this medicine along with mifepristone, which is used to cause an abortion during the early part of a pregnancy. Kadiflam decreases the absorption of mifepristone. Kadiflam should not be used for 8-12 days after taking mifepristone.
Special instructions need to be followed while taking this medicine along with colestipol and cholestyramine:, which are used to lower blood cholesterol levels. These medicines can decrease the absorption of Kadiflam. Take Kadiflam at least one hour before or 4 to 6 hours after taking colestipol/cholestyramine.
Kadiflam Tablet interacts with quinolones, which are used to treat bacterial infections. When Kadiflam is used with quinolones, it may cause seizures. Patients should be cautious when using both medicines together.
There may be an interaction of Kadiflam with antidiabetics, which are used to treat high blood glucose. When Kadiflam is used with antidiabetics, it can either increase or decrease the blood glucose levels. Monitoring of the blood glucose level is recommended in patients taking both medicines together.
This page does not contain all the possible interactions of Kadiflam Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Kadiflam is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.

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