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Why it's used

Xepabet Tablet is used to treat diabetes that occurs before the age of 25 years (called as maturity onset diabetes mellitus). This medicine works by raising the level of insulin produced by the pancreas. This medicine helps by lowering the blood glucose level.
When not to use
Xepabet should not be used to treat high blood sugar level due to the little or absence of insulin production (juvenile onset diabetes mellitus).
Sulfonylurea
Xepabet is a prescription medicine that belongs to a class of medicines called Sulfonylurea. Sulfonylureas are a class of antidiabetic drugs used in the management of diabetes mellitus type 2. These medicines act by increasing the release of insulin from the pancreas.

How to use

Follow directions on the product label, information guide, and provided by your doctor before using Xepabet. Eat this medicine as per your doctor's instructions.
You should track your blood sugar regularly. Discuss your results with the doctor specifically if your measurements are too low or too high. Your treatment plan may need changes.
Xepabet is eaten with or without food. To minimize low blood sugar, take this medicine with food. This medicine should be taken a whole with a glass of water.
The typical adult dose of Xepabet is 40-80 mg daily based on patient's response if higher dose required then taken twice daily and single dose should not be increased above 160 mg (not more than 320 mg/day). The maximum dose for adults of Xepabet is 320 mg in two divided doses daily per day. Xepabet is typically used at the same time every day. There are no known habit-forming tendencies with this medicine.
Xepabet is to be used for longer periods of time.
Tell your doctor if you develop new symptoms. Talk to your doctor if feeling ill, fever, stress, infection, injury, and need surgery.
To see the impact of Xepabet Tablet on the body, your doctor may recommend a lower initial dose. Please follow your doctor's instructions carefully.
The safety and effectiveness of using this medicine in children has not been established.
To decrease the possibility of side-effects, you might be recommended to use the extended-release form of this medicine by your doctor. The extended-release medicine helps in maintaining a steady level of the medicine in your body for a longer period of time. Do not crush or chew the medicine, unless indicated on the package or by your doctor.
Avoid drinking alcohol with Xepabet.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Xepabet Tablet for symptoms for which it was not prescribed. Do not give Xepabet Tablet to others who may have similar symptoms as you. Self-medication can cause harm.
Store Xepabet Tablet below 25°C (77°F), and away from moisture. Keep this medicine away from children and pets.

How to take Xepabet

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Xepabet depends on the following factors:
  • response to treatment

Xepabet Dosage

Dosage for diabetes that occur before the age of 25 years (called as maturity onset diabetes mellitus)

Adult
  • Recommended: 40-320 mg in two divided doses daily and single dose should be less than or up to 160 mg
  • Initial: 40-80 mg daily
  • Maximum: 320 mg daily

Forms

Tablet
Strength: 80 mg
Extended Release Tablet
Strength: 30 mg and 60 mg

Missed Dose

The missed dose of Xepabet should be taken immediately when you remember it, skip the dose if its almost time for the next dose. Then continue with the regular schedule. Do not take a double dose to make up for the missed dose.

Overdose

What to do if you overdose on Xepabet?
If this happens, contact your doctor immediately. Take some sugar or carbohydrates to raise blood sugar level to treat symptoms of low blood sugar. In such case, dosage adjustment, change in diet and strict monitoring are recommended. If the symptoms are severe or prolonged such as coma, seizures or other nervous system disorders (neurological disorders), it requires immediate hospitalization. In coma due to low blood sugar level, an injection of 50 ml of glucose solution (20-30%) should be given in the vein followed by infusion of a dilute glucose solution (10%) at a rate above 1000 mg/L. The patients should be monitored closely and depending on the patient's condition after this time, the doctor will decide if further monitoring is necessary.
Symptoms of an overdose of Xepabet
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Xepabet Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Xepabet

Before you use Xepabet, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Discuss with your doctor if you are allergic to sulfonylureas, sulfonamide antibiotics, or thiazide diuretics.
Before you use Xepabet Tablet, tell your doctor of your medical history including kidney problems, liver problems, abnormal growth in the pancreas (called insulinoma), hormonal problems (adrenal, pituitary and thyroid problems), heart failure, or a genetic disorder called Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD). Before having any surgery, discuss with your doctor and dentist about medicines you use including prescription medicines, non-prescription medicines, and herbal supplements.
The use of Xepabet Tablet may change blood glucose levels. This medicine may cause a low blood glucose level. It is advised to monitor blood glucose levels regularly.
Consult with your doctor on the use of Xepabet Tablet during pregnancy or if you are planning to become pregnant. If this medicine is used during pregnancy, it may affect the developing baby. Xepabet Tablet is not safe for use in women who are breastfeeding. If you are breastfeeding, discuss with your doctor if you should either discontinue breastfeeding, or stop using this medicine during this period. It is unknown if Xepabet passes into breast milk. However, other sulfonylureas pass into breast milk and increase the risk of low blood glucose in the baby. Consult with your doctor on the use of Xepabet Tablet, if you are trying to conceive.
Avoid drinking alcohol with Xepabet. Consumption of alcohol may cause a low blood glucose level, and coma.
Xepabet can make you feel sleepy. Be careful, especially while driving, while using heavy machinery, or when doing any activity that needs you to be completely alert. The consumption of alcohol with Xepabet can worsen the sleepiness. Xepabet may cause seizures in some people. Hence, you should discuss with your doctor before performing any activities where a loss of consciousness may cause harm to you or others.
This medicine may increase your sensitivity to sunlight and make you prone to sunburn. If this happens, limit your time outdoors to prevent sunburn. Use a sunscreen and cover your skin when you are outdoors. If you get sunburns on your body, consult with your doctor.
Older patients may have a higher incidence of side-effects when using Xepabet Tablet. Elderly patients may see an increased risk of low blood glucose level.

Xepabet Side-effects

The following side-effects may commonly occur when using Xepabet Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in older patients on the use of Xepabet Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:
Rarely, the use of Xepabet Tablet may cause the following side-effects:
  • aggression
  • confusion
  • develop bruising or bleeding
  • dizziness (dizziness or giddiness)
  • double vision
  • drowsiness
  • fainting
  • fatigue
  • feeling of fullness in the stomach
  • feeling of powerlessness
  • feeling or being sick
  • flu-like symptoms, with blisters, red rashes, or sores around lips, mouth, genital and anal region
  • hay fever like symptoms
  • headache
  • heartburn
  • hives
  • hives on the skin
  • indigestion (dyspepsia)
  • insomnia
  • intense hunger
  • itching
  • itchy, red veins
  • lack of energy (lassitude)
  • lack of focus
  • language disorder (aphasia)
  • loss of appetite
  • loss of self-control
  • mild rash
  • mouth ulcers
  • nausea
  • numbness
  • pale skin
  • palpitations
  • rash (maculopapular rashes)
  • reddish or purplish patches under the skin
  • redness of the skin
  • reduced awareness and slowed reactions
  • sensory disorders
  • severe chills
  • severe itching
  • sore throat
  • speech disorders
  • stomach pain (abdominal pain)
  • stomach upset
  • sweating
  • sweaty skin (clammy skin)
  • swelling of the face, lips, tongue, throat or other parts of the body
  • trembling
  • tremor
  • weight loss
The following severe side-effects may also occur when using Xepabet Tablet:
  • liver diseases (hepatobiliary disorders) (life-threatening liver failure)
    Symptoms: increased level of liver enzymes (aspartate aminotransferase, alanine transaminase, alkaline phosphatase), inflammation of the liver (hepatitis), yellowing of the skin, yellowing of the eyes, dark urine, pale stools and jaundice
    These side-effects go away upon discontinuation of Xepabet. This medicine should be discontinued if a liver disease such as cholestatic jaundice occurs.
  • skin and soft tissue disorders (skin and subcutaneous tissue disorders)
    Symptoms: rash (maculopapular rashes), severe itching, hives, redness of the skin (erythema), blisters on the skin and allergy to sunlight (photosensitivity skin reactions)
  • blood and lymphatic system disorders (such as anaemia, granulocytopenia)
    These side-effects go away upon discontinuation of Xepabet.
  • stomach and intestinal disorders (gastrointestinal disturbances)
    Symptoms: stomach pain (abdominal pain), nausea, vomiting, indigestion (dyspepsia), diarrhea, constipation, vomiting blood, passing bloody and black or tarry stools
    This medicine should be taken with a meal to avoid or decrease the incidence of such side-effects.
  • low blood sugar level (hypoglycaemia) (coma and can be possibly fatal)
    Symptoms: headache, intense hunger, nausea, vomiting, lack of energy (lassitude), insomnia, agitation, aggression, lack of focus, reduced awareness, slowed reactions, depression, confusion, visual disorders, speech disorders, language disorders (aphasia), tremor, paralysis, sensory disorders, dizziness, feeling of powerlessness, loss of self-control, delirium, seizures, shallow breathing (shallow respiration), decreased heartbeat, drowsiness, loss of consciousness, sweating, sweaty skin (clammy skin), anxiety, increased heartbeat, high blood pressure, palpitation, chest pain and irregular heartbeat
    If a severe episode of diabetes occurs, immediate treatment or hospitalization is needed even if briefly controlled by taking sugar.
  • eye disorders
    Symptoms: temporary visual disturbances
  • allergic reactions
    Symptoms: shortness of breath, wheezing, difficulty in breathing, facial swelling, swelling of the lips, swelling of the tongue, swelling of the throat, swelling of other body parts, severe rash, itching, hives, fainting and hay fever like symptoms
    This medicine should not be used if an allergic reaction occurs, and contact the doctor immediately.
  • chest pain due to the reduced blood supply to the heart (angina)
    Symptoms: chest pain
    If this happens, contact the doctor immediately.
  • flu like symptoms (can be fatal)
    Symptoms: red rashes, sores around the mouth, sores around the lips and sores around the genital and anal region
    If such side effects occur, contact the doctor immediately.
Your doctor has prescribed this Xepabet because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Xepabet.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Low blood glucose level

Patients who intake low-calorie diet, skipping meals, lack of sufficient nutrients and the imbalance between carbohydrate intake and physical exercise are at an increased risk when using this medicine. Patients having irregular meal time, kidney insufficiency, severe liver insufficiency, hormonal disorders (such as thyroid disorders, adrenal insufficiency and decreased hormone secretion by the pituitary gland) and the overdose of Xepabet or alcohol intake are also at an increased risk when using this medicine. Such patients may have an increased risk of low blood glucose level. It is necessary to give proper instructions to the patient and the dosage should be carefully selected.

Kidney and liver insufficiency

Patients with kidney and liver an insufficiency are at increased risk when using this medicine. In these patients, low blood glucose level may occur for a prolonged time. If this happens, proper management should be started.

Poor blood glucose control

Patients receiving antidiabetic treatment are at an increased risk when using this medicine. In such patients, blood glucose control may be affected by fever, infection, trauma, or surgery. The blood glucose level lowering effect of oral antidiabetic medicines is reduced over time in several cases. This may be due to a rise in the severity of diabetes, or to a decreased response to treatment. This is known as a secondary failure. In some cases, this may be necessary to give insulin. The sufficient dose adjustment and proper diet should be given before assigning the patient as a secondary failure.

Anemia due to the breakdown of red blood cells (called as hemolytic anemia)

Patients with a genetic disorder called Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD) are at an increased risk when using this medicine. These patients may develop hemolytic anemia. It is advised to use caution in these patients and a non-sulfonylurea as an alternative should be used.

Measurement of levels of glucose in hemoglobin (glycated hemoglobin levels)

Measurement of glycated hemoglobin levels is needed to estimate the blood glucose control. Self-monitoring of blood glucose level may also be useful.

Patients with the risk of low blood sugar

The risk of low blood sugar and conditions that influence its development, symptoms, and treatment should be disclosed to the patient and family members. The importance of receiving dietary advice, regular exercise, and regular monitoring of blood glucose levels should be informed to the patient.

Interactions with Xepabet

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Xepabet Tablet may interact with miconazole, which is used to treat fungal infection. When Xepabet is used with miconazole, the blood glucose level lowering effect of Xepabet is increased and it may result in symptoms of low blood sugar level or even coma. This medicine should not be used in combination with miconazole.
There may be an interaction of Xepabet with phenylbutazone, which is used to treat mild to moderate pain, fever, and inflammation in the body. When Xepabet is used with phenylbutazone may increase the blood glucose lowering effect of Xepabet. It is advised to use another anti-inflammatory agent and tell the importance of self-monitoring to the patient. If required, the dose of Xepabet may be adjusted during and after treatment with phenylbutazone.
Xepabet Tablet interacts with alcohol. When the Xepabet is used with alcohol, the blood sugar level lowering effect of Xepabet is increased and it may lead to the onset of low blood sugar related coma. When using Xepabet, use of alcohol or alcohol containing medicines should be avoided.
Special instructions need to be followed while taking this medicine along with other blood sugar level lowering agents (for example, insulins, acarbose, biguanides), which are used to treat high blood sugar level. When one of these medicines is used with Xepabet, the blood sugar lowering effect is increased.
Your doctor's guidelines may need to be followed while taking this medicine along with danazol, which is used to treat abnormal growth of endometrial tissues (endometriosis) and breast lumps (fibrocystic breast disease) in women. When Xepabet is used with danazol, it can cause diabetes. Xepabet should not be used with danazol. The dose of an antidiabetic agent should be adjusted during and after treatment with danazol. The patient should be informed about the importance of blood sugar or urine monitoring.
Xepabet Tablet may interact with chlorpromazine, which is used to treat mental disorders. The high dosages of chlorpromazine raise blood glucose levels. The patient should use caution when using Xepabet and chlorpromazine together. Inform the patient about the monitoring of blood glucose level. The dose adjustment of antidiabetic agent may be necessary during and after treatment with chlorpromazine.
There may be an interaction of Xepabet with glucocorticoids and tetracosactrin, which are used to treat inflammation. Glucocorticoids and tetracosactrin may cause a rise in the blood glucose levels with possibly increased levels of ketone bodies (ketosis). The patient should use caution when using Xepabet and glucocorticoids or tetracosactrin together. The dose of an antidiabetic agent should be adjusted during and after treatment with glucocorticoids and tetracosactrin. The patient should be informed about the importance of blood sugar monitoring, especially at the starting of treatment.
Xepabet Tablet interacts with ritodrine and salbutamol, which are used to control premature labor and to treat asthma respectively. When Xepabet is used with ritodrine and salbutamol injection in the vein, the blood glucose level increases due to beta-2 agonist effect of ritodrine and salbutamol. The patients should be regularly monitored for changes in blood glucose level. Insulin can be used as an alternative medicine instead of Xepabet if required.
Special instructions need to be followed while taking this medicine along with terbutaline, which is used to treat asthma and to control premature labor. When Xepabet is used with terbutaline injection in the vein, the blood glucose level increases due to beta-2 agonist effect of terbutaline. In such patients, blood glucose level should be strictly monitored. Use insulin as an alternative medicine, if required.
Your doctor's guidelines may need to be followed while taking this medicine along with blood thinners (warfarin), which is used to prevent blood clots. When Xepabet is used with blood thinners such as warfarin, it may increase the risk of blood clot formation. The dose adjustment of the blood thinners may be required in such patients.
Xepabet Tablet may interact with octreotide, which is used to treat severe diarrhea or abnormal growth of cells (tumors) in intestine or pancreas. When Xepabet is used with octreotide, the blood glucose level lowering effect of Xepabet increases.
There may be an interaction of Xepabet with sulfinpyrazone, which is used to treat red, stiff and painful joints (gout). When Xepabet is used with sulfinpyrazone, the blood glucose level lowering effect of Xepabet increases.
Xepabet Tablet interacts with antibiotics (tetracycline compounds and chloramphenicol), aminoglutethimide, which is used to treat seizures and breast cancer and testosterone, which is used to treat hormonal imbalance. If Xepabet and aminoglutethimide are used together, there is an increase in the breakdown of Xepabet.
Special instructions need to be followed while taking this medicine along with fluconazole, histamine 2-receptor antagonists, monoamine oxidase inhibitor (MAOIs), and sulfonamides; which are used to treat fungal infection, stomach ulcers, depression, and bacterial infection respectively. When one of these medicines is used with Xepabet, the blood sugar lowering effect is increased.
Your doctor's guidelines may need to be followed while taking this medicine along with beta-blockers, angiotensin converting enzyme inhibitors (captopril, enalapril); which are used to treat high blood pressure and nonsteroidal anti-inflammatory agents, which are used to treat fever, mild to moderate pain and inflammation. When Xepabet is used with any one of these medicines, there is an increase in blood sugar lowering effect.
This page does not contain all the possible interactions of Xepabet Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Xepabet is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.

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