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Intelligence » Anemia » Last Week

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Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia

Thursday, December 13, 2018 -- Anemic stress induces a physiological response that includes the rapid production of new erythrocytes. This process is referred to as stress erythropoiesis. It is best understood in the mouse where it is extramedullary and utilizes signals and progenitor cells that are distinct from bone marrow steady-state erythropoiesis. The development of stress erythroid progenitors occurs in close association with the splenic stress erythropoiesis niche. In particular, macrophages in the niche are required for proper stress erythropoiesis. Here we show that the expansion of the niche occurs in concert with the proliferation and differentiation of stress erythroid progenitors. Using lineage tracing analysis in 2 models of anemic stress, we show that the expansion of the splenic niche is due to the

FibroGen Announces Approval of Roxadustat in China for the Treatment of Anemia in Chronic Kidney Disease Patients on Dialysis Nasdaq:FGEN

Monday, December 17, 2018 -- (MENAFN - GlobeNewsWire - Nasdaq) itemprop="articleBody">China is the first country to approve roxadustat First-in-class roxadustat offers a new, effective oral treatment SAN F...

Limiting blood transfusions for moderate anemia safe

Monday, December 17, 2018 -- In recent years, the prevalence of moderate anemia after hospitalization has increased while red blood cell transfusions have decreased, but morbidity, mortality and rehospitalization have not been adversely affected, according to findings published in Annals of Internal Medicine.Other researchers argued that the study design limits the applicability and clinical value of the reported results.“Randomized clinical trial findings support decreased red blood cell (RBC) transfusion and short-term tolerance of in-hospital anemia,” Nareg H. Roubinian, MD, MPHTM, from Kaiser Permanente