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    Arthritis highly prevalent in older adults with depression

    Thursday, September 20, 2018 -- A study published in the International Journal of Geriatric Psychiatry reported that arthritis was highly prevalent among older adults with varying degrees of depression.“Depression is highly prevalent yet one of the most undertreated and poorly understood psychosocial factors related to arthritis, with nearly half of older adults with both chronic pain and depression receiving either inadequate or no mental health care,” Jessica M. Brooks, PhD, from the department of psychiatry, Geisel School of Medicine and Centers for Health and Aging, Dartmouth College, and colleagues wrote.

    Arthritis common in individuals with varying degrees of depression, finds study

    Wednesday, September 19, 2018 -- Arthritis is common in individuals with varying degrees of depression, according to a new International Journal of Geriatric Psychiatry study.

    Ketamine Infusions Reduce Suicidal Ideation in Depression: Characterizing Different Responses

    Tuesday, September 18, 2018 -- Researchers found 3 distinct subgroups of patients in relation to suicidal ideation and effects of ketamine, with one group's suicidal ideation completely eliminated and the other group's improvement independent of depressed mood.

    A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression

    Wednesday, September 19, 2018 -- The serotonin-1A (5-HT1A) receptor is a key regulator of serotonergic activity and is implicated in mood and emotion. However, its post-transcriptional regulation has never been studied in humans. In the present study, we show that the "intronless" human 5-HT1A gene (HTR1A) is alternatively spliced in its 3'-UTR, yielding two novel splice variants. These variants lack a ~1.6 kb intron, which contains an microRNA-135 (miR135) target site. Unlike the human HTR1A, the mouse HTR1A lacks the splice donor/accepter sites. Thus, in the mouse HTR1A, splicing was not detected. The two spliced mRNAs are extremely stable, are resistant to miR135-induced downregulation, and have greater translational output than the unspliced variant. Moreover, alternative HTR1A RNA splicing is oppositely regulated by the splice

    New study to explore genetic links to depression and anxiety

    Tuesday, September 18, 2018 -- Researchers are calling for 40,000 people with depression or anxiety in England to join an online study hoping to explore any genetic links to these conditions.

    Pain Severity May Partly Mediate the Association Between Depression and Physical Performance in Knee OA

    Thursday, September 20, 2018 -- Pain may partly mediate the observed association between physical performance and depressive symptoms in patients with radiographic knee osteoarthritis.

    Combination Cognitive Behavioral Therapy With Fluoxetine Effective for Adolescent Depression

    Wednesday, September 19, 2018 -- These data suggest that combination therapy not only produces greater proportional response in depression symptoms it is also effective in a broader range of individuals.

    Autism Spectrum Disorders Associated With Depression in Young Adults

    Thursday, September 20, 2018 -- Investigators examined whether individuals with ASD were more likely to be diagnosed with depression in adulthood.

    Chronic VNS May Improve Quality of Life in Major Depressive Disorders

    Tuesday, September 18, 2018 -- Adjunctive vagus nerve stimulation may result in greater improvements in quality of life in patients with treatment-resistant depression.

    Cost-Effective Telehealth Alternatives for Veterans With Depression

    Thursday, September 20, 2018 -- Researchers working with a population of veterans found that the healthcare utilization costs of telehealth services were significantly cheaper compared with in-person visits, with only a relatively small difference in quality of life.

    Gestational Diabetes Associated With Increased Risk for Postpartum Depression

    Wednesday, September 19, 2018 -- These findings suggest an increased risk for postpartum depressive symptoms in mothers with gestational diabetes, independent of depressive symptomatology during pregnancy.

    Transdermal Nicotine Boosts Mood and Cognitive Function in Late-Life Depression

    Tuesday, September 18, 2018 -- Results showed a significant change in depression severity with a mean MADRS reduction of 18.45 and a response rate of 86.7%.