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    Lupus nephritis remission predicts long-term renal survival

    Tuesday, March 20, 2018 -- Beulah JiAmong patients with lupus nephritis, achieving renal remission 2 years after initial diagnosis is a significant predictor of long-term renal survival, according to findings published in the Journal of Rheumatology.“Approximately 25% to 50% of systemic lupus erythematosus (SLE) patients develop clinically significant lupus nephritis and despite improvements in both diagnosis and treatment over the last few decades it remains an indicator of poor prognosis,” Beulah Ji, MD, a project physician leader for GlaxoSmithKline R&D, told Healio Rheumatology. “Clinical

    [Articles] Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

    Thursday, March 15, 2018 -- These data show that a progressive improvement in disease activity is associated with correction of pro-inflammatory T-cell lineage specification in patients with active systemic lupus erythematosus during 12 months of sirolimus treatment. Follow-up placebo-controlled clinical trials in diverse patient populations are warranted to further define the role of mTOR blockade in treatment of systemic lupus erythematosus.

    Autoimmune Reactivity to Malondialdehyde in SLE Linked to High Disease Activity, Lupus Nephritis

    Thursday, March 15, 2018 -- Researchers investigated serum IgG anti-MDA expression and associations with disease activity in patients with systemic lupus erythematosus.

    Examining Remission Status as a Predictor of Long-Term Renal Survival in Lupus Nephritis

    Monday, March 19, 2018 -- Remission status was a significant and useful predictor of renal survival, in patients with lupus nephritis.