Monday, June 18, 2018 -- Novartis and Celgene/Juno release longer term data on important lymphoma indication at EHA
Tuesday, June 19, 2018 -- by Xiaojuan Gao, Jia Li, Yaqi Wang, Shuai Liu, Baohong Yue Recent studies show that Epstein-Barr virus (EBV) positivity might be related to adverse prognosis in patients with diffuse large B-cell lymphoma (DLBCL), but the results are still inconclusive. We conducted this meta-analysis to define the clinical value of EBV infection in DLBCL. All potential articles in PubMed, Web of Science, Medline, and Embase were retrieved. Using the random-effects or fixed-effect model, pooled hazard ratios (HRs) or relative risk (RR) with 95% confidence intervals (CIs) were used to calculate the correlation between EBER and prognosis and clinical features in DLBCL. A total of 13 qualified studies with 4111 patients were identified in our meta-analysis based on the inclusion and
Thursday, June 21, 2018 -- Tumors accumulate high levels of mutant p53 (mutp53), which contributes to mutp53 gain-of-function properties. The mechanisms that underlie such excessive accumulation are not fully understood. To discover regulators of mutp53 protein accumulation, we performed a large-scale RNA interference screen in a Burkitt lymphoma cell line model. We identified transformation/transcription domain-associated protein (TRRAP), a constituent of several histone acetyltransferase complexes, as a critical positive regulator of both mutp53 and wild-type p53 levels. TRRAP silencing attenuated p53 accumulation in lymphoma and colon cancer models, whereas TRRAP overexpression increased mutp53 levels, suggesting a role for TRRAP across cancer entities and p53 mutations. Through clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 screening, we identified a 109-amino-acid region in the N-terminal HEAT repeat region
Wednesday, June 20, 2018 -- Celgene Corporation (NASDAQ:CELG) today announced updated six-month safety and efficacy data from the TRANSCEND (NHL-001) study of lisocabtagene maraleucel (liso-cel; JCAR017), an investigational CD19-directed CAR T cell therapy, in patients with relapsed/refractory (r/r) aggressive B-cell non-Hodgkin lymphoma (NHL) in a presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL. Read more..
Wednesday, June 20, 2018 -- AbbVie (NYSE: ABBV), a research-based global biopharmaceutical company, today announced the U.S. Food and Drug Administration (FDA) has approved, under priority review, VENCLEXTA® (venetoclax tablets) in combination with rituximab for the treatment of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), with or without 17p deletion, who have received at least one prior therapy Read more..
Wednesday, June 20, 2018 -- Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that the U.S.Food and Drug Administration (FDA) has approved KEYTRUDA®, the company’s anti-PD-1 therapy, for the treatment of adult and pediatric patients with refractory primary mediastinal large B-cell lymphoma (PMBCL), or who have relapsed after two or more prior lines of therapy. Read more..
Wednesday, June 20, 2018 -- Trillium Therapeutics recently dosed the first patient in its Phase 1 clinical trial of TTI-622, a checkpoint inhibitor of the immune system being developed for the treatment of relapsed or refractory lymphoma and myeloma. Although the innate immune system is a key ally in fighting cancer, tumor cells may learn to evade immune attacks by activating “hiding” […] The post Trillium Doses First Patient with TTI-622, a Candidate for Treating Myeloma, Lymphoma appeared first on Myeloma Research News.
Monday, June 18, 2018 -- Results of a prospective phase 3 study demonstrated noninferiority of R-THP-COP for diffuse large B cell lymphoma to the standard of care, suggesting the regimen may be an alternative option for these patients.
Monday, June 18, 2018 -- In patients with indolent non-Hodgkin lymphoma, or iNHL, treatment with bendamustine is associated with an increased risk for common and opportunistic infections compared with other chemotherapy regimens, researchers reported in Clinical Infectious Diseases.“Bendamustine is a potent chemotherapy agent increasingly used to treat [iNHL],” wrote Monica Fung, MD clinical fellow in infectious diseases at the University of California, San Francisco, and colleagues. “While effective, it causes significant T-cell lymphopenia, which may increase risk of infection. We examined
Monday, June 18, 2018 -- (MedPage Today) -- Preexisting aberrant B-cell clone implicated