Tuesday, June 19, 2018 -- by Julian Rothen, Carl Murie, Jason Carnes, Atashi Anupama, Salim Abdulla, Mwajuma Chemba, Maxmillian Mpina, Marcel Tanner, B. Kim Lee Sim, Stephen L. Hoffman, Raphael Gottardo, Claudia Daubenberger, Ken Stuart Malaria continues to be one of mankind’s most devastating diseases despite the many and varied efforts to combat it. Indispensable for malaria elimination and eventual eradication is the development of effective vaccines. Controlled human malaria infection (CHMI) is an invaluable tool for vaccine efficacy assessment and investigation of early immunological and molecular responses against Plasmodium falciparum infection. Here, we investigated gene expression changes following CHMI using RNA-Seq. Peripheral blood samples were collected in Bagamoyo, Tanzania, from ten adults who were injected intradermally (ID) with 2.5x104 aseptic, purified, cryopreserved P.
Monday, June 18, 2018 -- Treatment regimens currently recommended for uncomplicated Plasmodium falciparum malaria may be inadequate for pregnant women during the second and third trimesters and for young children. Findings from a study published in PLoS Medicine demonstrate that increasing the duration and frequency of treatment may be more beneficial for this population.“The fixed-dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria,” Frank Kloprogge, a senior research fellow at the Institute for Global Health, University