Sunday, March 18, 2018 -- The Taiwan Centers for Disease Control (Taiwan CDC) reported Thursday on a meningococcal meningitis death in an one-year-old girl who resides in northern Taiwan. Taiwan CDC reports the timeline: On March 2, she developed symptoms, including cold and fever, and sought medical attention at a clinic. Her conditions improved after taking the medication. On March, 11, […] The post Taiwan reports meningococcal meningitis death in young child appeared first on Outbreak News Today.
Tuesday, March 20, 2018 -- Researchers at the University’s Institute of Infection and Global Health are developing a new commercial blood test to improve the diagnosis and management of patients with suspected meningitis. The £1.6m project, which is funded by the Medical Research Council and industrial partner Fast Track Diagnostics, could also help cut unnecessary antibiotic treatment – a practice that is indirectly […] The post Meningitis blood test being developed by University of Liverpool researchers appeared first on Outbreak News Today.
Tuesday, March 20, 2018 -- Children in South Asia and Africa continue to face the threat of infection from meningitis. Despite progress in vaccines, there are still poor health infrastructures in key areas and inadequate access to medical services. The World Health Organization (WHO) says promoting vaccination programs faces challenges, with outbreaks of several forms of meningitis causing child mortality rates as high as 60 percent across Sub-Saharan Africa. Meningitis still threatens children Mathuram Santosham, a professor of pediatrics and pediatric medicine at John Hopkins Bloomberg School of Medicine, said while vaccinations programs have been very successful in the West and developed regions, children in developing countries remain at risk. "The disease pretty much disappeared in the U.S., Europe and other countries. It's now working
Monday, March 19, 2018 -- by Vasudevan Bakthavatchalu, Katherine J. Wert, Yan Feng, Anthony Mannion, Zhongming Ge, Alexis Garcia, Kathleen E. Scott, Tyler J. Caron, Carolyn M. Madden, Johanne T. Jacobsen, Gabriel Victora, Rudolf Jaenisch, James G. Fox Immune-compromised mouse models allow for testing the preclinical efficacy of human cell transplantations and gene therapy strategies before moving forward to clinical trials. However, CRISPR/Cas9 gene editing of the Wsh/Wsh mouse strain to create an immune-compromised model lacking function of Rag2 and Il2rγ led to unexpected morbidity and mortality. This warranted an investigation to ascertain the cause and predisposing factors associated with the outbreak. Postmortem examination was performed on 15 moribund mice. The main lesions observed in these mice consisted of ascending urogenital tract infections, suppurative
Monday, March 19, 2018 -- In resource-limited settings, a shorter 1-week course of amphotericin B plus flucytosine is the most effective option for induction therapy in patients with HIV-associated cryptococcal meningitis, according to findings from a phase 3 trial published in The New England Journal of Medicine.Results from the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) trial also suggested that an oral combination of fluconazole plus flucytosine is an effective and sustainable option in places where amphotericin B is unavailable or cannot be administered safely, Síle F. Molloy, PhD,
Friday, March 16, 2018 -- The results of the ACTA trial were presented at the 9th IAS Conference on HIV Science held in Paris from 23 to 26 July 2017. Professor Thomas Harrison and his colleagues at St George's University of London, the Institut Pasteur in Paris, Paris Descartes University (Hôpital Necker-Enfants Malades), the ANRS site in Cameroon, and the MRC sites in Malawi, Tanzania, and Zambia show in this trial that new therapeutic regimens are of benefit in HIV-infected patients with cryptococcal meningitis.