Monday, July 16, 2018 -- Conditions such as sleep problems, irritable bowel syndrome and depression are more common among multiple sclerosis patients -- five years before they develop medically recognized signs of the disease, a new study from the University of British Columbia suggests.
Tuesday, June 19, 2018 -- While the DNA sequence remains the same throughout a person's life, the expression of the encoded genes may change with time and contribute to disease development in genetically predisposed individuals.
Monday, July 16, 2018 -- During the five years before people develop the first clinically recognized signs of multiple sclerosis, they are up to four times more likely to be treated for nervous system disorders such as pain or sleep problems, and are 50 per cent more likely to visit a psychiatrist, according to new research from the University of British Columbia.
Wednesday, June 20, 2018 -- Rituximab may be effective for the treatment of relapsing-remitting multiple sclerosis.
Monday, July 09, 2018 -- BACKGROUND AND PURPOSE: MR imaging–pathologic studies have reported that paramagnetic rims on 7T susceptibility-based MR imaging identify, in vivo, the subset of MS lesions with compartmentalized inflammation at the lesion edge and associated remyelination failure. Here, we assessed the reliability of detecting these rims on high-resolution 3T phase images. MATERIALS AND METHODS: High-resolution T2* and phase MR imaging was collected in 20 patients with MS at 3T (3D segmented EPI, 0.65 mm3) and 7T (2D gradient-echo, 0.2 x 0.2 x 1 mm) MR imaging. In each case, 5 discrete chronic (nonenhancing) MS lesions were selected on T2 FLAIR images for rim evaluation. Five raters experienced in MS imaging contributed to the rim assessment, of whom 3 worked independently on
Monday, July 09, 2018 -- BACKGROUND AND PURPOSE: Both clinical and imaging criteria must be met to diagnose neuromyelitis optica spectrum disorders and multiple sclerosis. However, neuromyelitis optica spectrum disorders are often misdiagnosed as MS because of an overlap in MR imaging features. The purpose of this study was to confirm imaging differences between neuromyelitis optica spectrum disorders and MS with visually detailed quantitative analyses of large-sample data. MATERIALS AND METHODS: We retrospectively examined 89 consecutive patients with neuromyelitis optica spectrum disorders (median age, 51 years; range, 16–85 years; females, 77; aquaporin 4 immunoglobulin G–positive, 93%) and 89 with MS (median age, 36 years; range, 18–67 years; females, 68; relapsing-remitting MS, 89%; primary-progressive MS, 7%; secondary-progressive MS, 2%) from 9 institutions across Japan (April
Monday, July 09, 2018 -- Patients with increased disease activity seen on MRI or with elevated CSF NfL should be considered for disease-modifying immune therapy.
Friday, June 29, 2018 -- No correlation was found between baseline 25-hydroxyvitamin D level and annualized relapse rates or time to first relapse.
Wednesday, June 27, 2018 -- The association between α-linolenic acid and multiple sclerosis disease activity was examined.
Monday, June 25, 2018 -- Investigators note that depression should be evaluated and treated in patients with multiple sclerosis and may hinder balance rehabilitation.
Monday, July 02, 2018 -- The posterior cingulate cortex, precuneus, and thalamus were among the earliest regions to become atrophic in both relapse-onset phenotypes and primary-progressive multiple sclerosis.