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Secondary osteoporosis, rheumatoid arthritis improve FRAX accuracy in multiple sclerosis

Monday, February 04, 2019 -- The Fracture Risk Assessment Tool, or FRAX, underestimated the observed 10-year risk for major osteoporotic fracture by up to 5% among adults with multiple sclerosis; however, calibration improved when including secondary osteoporosis or rheumatoid arthritis as proxies for additional risk, according to findings published in the Journal of Bone and Mineral Research.“Our study extends the range of clinical conditions where FRAX has been shown to be of value for assessing fracture risk, but it may underestimate that risk in people with multiple sclerosis (MS),” William D. Leslie, MD,

A 3T Phase-Sensitive Inversion Recovery MRI Sequence Improves Detection of Cervical Spinal Cord Lesions and Shows Active Lesions in Patients with Multiple Sclerosis [SPINE]

Wednesday, February 13, 2019 -- BACKGROUND AND PURPOSE: Magnetic Resonance Imaging is the modality of choice to detect spinal cord lesions in patients with Multiple Sclerosis (MS). However, this imaging is challenging. New sequences such as phase-sensitive inversion recovery have been developed to improve detection. Our aim was to compare a 3D phase-sensitive inversion recovery and a conventional imaging dataset including postcontrast T2WI and T1WI to detect MS spinal cord lesions. MATERIALS AND METHODS: This retrospective single-center study included 100 consecutive patients with MS (mean age, 41 years) from January 2015 to June 2016. One senior neuroradiologist and 1 junior radiologist blinded to clinical data checked for new spinal cord lesions, individually analyzing conventional and 3D phase-sensitive inversion recovery datasets separately, placing a 3-week

Intereye RNFL differences useful for predicting optic nerve lesion in multiple sclerosis

Friday, February 01, 2019 -- The optic nerve is a frequent site for involvement in multiple sclerosis (MS). Using OCT, the authors sought to determine optimal thresholds for intereye difference in peripapillary retinal nerve fiber layer (RNFL) thickness that are most predictive of a unilateral optic nerve lesion.

Movement Disorders Highly Prevalent in Early Multiple Sclerosis

Thursday, January 24, 2019 -- Investigators observed a wide variety of movement disorders — including restless legs syndrome, tremor, and tonic spasms — associated with early demyelinating diseases.

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