Intelligence » Tuberculosis » Last Week

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    To Fight Tuberculosis in the Global South, Look to Apple as a Model

    Friday, March 16, 2018 -- Artist’s rendering of Mycobacterium tuberculosis, the bacterium that causes tuberculosis.

    PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection

    Monday, March 19, 2018 -- by Anneliese S. Ashhurst, Thaigarajan Parumasivam, John Gar Yan Chan, Leon C. W. Lin, Manuela Flórido, Nicholas P. West, Hak-Kim Chan, Warwick J. Britton Tuberculosis places a staggering burden on human health globally. The new World Health Organisation End-TB Strategy has highlighted the urgent need for more effective TB vaccines to improve control of the disease. Protein-based subunit vaccines offer potential as safe and effective generators of protective immunity, and the use of particulate vaccine formulation and delivery by the pulmonary route may enhance local immunogenicity. In this study, novel particulate subunit vaccines were developed utilising biodegradable poly(lactic-co-glycolic acid) (PLGA) slow-release particles as carriers for the Mycobacterium tuberculosis lipoprotein MPT83, together with the adjuvants trehalose-dibehenate (TDB) or Monophosphoryl lipid

    Tuberculosis treatment outcomes in Ethiopia from 2003 to 2016, and impact of HIV co-infection and prior drug exposure: A systematic review and meta-analysis

    Monday, March 19, 2018 -- by Setegn Eshetie, Mucheye Gizachew, Animut Alebel, Dick van Soolingen Background Knowledge of tuberculosis (TB) treatment outcomes is substantially needed to assess the performance of national TB controls programs (NTPs). To date, the overall estimates of treatment outcomes have not been determined in Ethiopia. Therefore, this meta-analysis was undertaken to produce pooled estimates of TB treatment outcomes and to analyze the impact of prior anti-TB drug exposure and HIV co-infection. Methods Potentially relevant studies were retrieved from PubMed, EMBASE, and MEDLINE online databases. The unpublished studies have been retrieved from the grey literature through Google and Google Scholar. The pooled estimates were calculated using random effect model. The summary estimates were also presented using Forest plots and Tables. The