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    PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins

    Tuesday, June 19, 2018 -- Zika virus infection stimulates a type I interferon (IFN) response in host cells, which suppresses viral replication. Type I IFNs exert antiviral effects by inducing the expression of hundreds of IFN-stimulated genes (ISGs). To screen for antiviral ISGs that restricted Zika virus replication, we individually knocked out 21 ISGs in A549 lung cancer cells and identified PARP12 as a strong inhibitor of Zika virus replication. Our findings suggest that PARP12 mediated the ADP-ribosylation of NS1 and NS3, nonstructural viral proteins that are involved in viral replication and modulating host defense responses. This modification of NS1 and NS3 triggered their proteasome-mediated degradation. These data increase our understanding of the antiviral activity of PARP12 and suggest a molecular basis for the

    Ornamental Bromeliad Plants Contribute to Zika-Carrying Mosquitoes

    Sunday, June 17, 2018 -- Interview with: André Wilke, Ph.D. Post Doctoral Associate Division of Environment & Public Health Department of Public Health Sciences University of Miami Miller School of Medicine Clinical Research Building Miami, Florida 33136 What is the background for this … Continue reading →

    Rhesus macaque model could be useful to test therapies for congenital Zika virus syndrome

    Thursday, June 21, 2018 -- Rhesus macaque monkeys infected in utero with Zika virus develop similar brain pathology to human infants, according to a report by researchers at the California National Primate Research Center and School of Veterinary Medicine at the University of California, Davis, published June 20 in Nature Communications.