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[Research Articles] DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment

Wednesday, February 13, 2019 -- Increased airway smooth muscle mass, a feature of airway remodeling in asthma, is the strongest predictor of airflow limitation and contributes to asthma-associated morbidity and mortality. No current drug therapy for asthma is known to affect airway smooth muscle mass. Although there is increasing evidence that prostaglandin D2 type 2 receptor (DP2) is expressed in airway structural and inflammatory cells, few studies have addressed the expression and function of DP2 in airway smooth muscle cells. We report that the DP2 antagonist fevipiprant reduced airway smooth muscle mass in bronchial biopsies from patients with asthma who had participated in a previous randomized placebo-controlled trial. We developed a computational model to capture airway remodeling. Our model predicted that a reduction in

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Tuesday, March 26, 2019 -- (Natural News) We all want the best for our little ones, right? Eating a healthy, well-balanced and nutritious diet during pregnancy is crucial to an unborn baby’s development. Researchers from the Copenhagen University Hospital in Denmark recently discovered that taking fish oil supplements during the third trimester of pregnancy could reduce a newborn’s risk of... Read More

Short-Term Exposure to Air Pollution May Increase Asthma Mortality

Friday, March 15, 2019 -- (MedPage Today) -- Odds of death up about 10% compared with low-pollution days in Chinese study

High doses of prenatal vitamin D not associated with children’s asthma risk

Wednesday, March 13, 2019 -- Women who took high doses of vitamin D supplementation during pregnancy did not impact their child’s risk for asthma by the age of 6 years, according to data recently published in JAMA.“The Copenhagen Prospective Studies on Asthma in Childhood 2010 vitamin D randomized clinical trial found that at the age of 3 years, children of women randomized to high-dose vs. standard-dose vitamin D did not have a statistically significant reduced risk of persistent wheeze; however, a clinically important protective effect could not be excluded,” Niklas Brustad, MD, of the Copenhagen

Unreasonable prescription costs leading to life-threatening asthma attacks

Tuesday, February 26, 2019 -- Asthma UK has revealed that people with asthma are rationing their medication due to prescription costs.

Asthma More Common in Opioid-Dependent Patients

Sunday, February 24, 2019 -- (MedPage Today) -- Also, women taking opioids have greatest asthma risk

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