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Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets

Thursday, December 13, 2018 -- by Joanna L. Kaplan, Joshua A. Stern, Andrea J. Fascetti, Jennifer A. Larsen, Hannah Skolnik, Gordon D. Peddle, Richard D. Kienle, Andrew Waxman, Michael Cocchiaro, Catherine T. Gunther-Harrington, Tyler Klose, Kendra LaFauci, Bonnie Lefbom, Maggie Machen Lamy, Rebecca Malakoff, Satoko Nishimura, Maureen Oldach, Steven Rosenthal, Christopher Stauthammer, Lynne O’Sullivan, Lance C. Visser, Regan William, Eric Ontiveros Introduction Golden retrievers are over-represented in cases of taurine-deficient dilated cardiomyopathy and recently a surge in cases has prompted further investigation. Objective To describe the clinical, dietary, and echocardiographic features in golden retrievers diagnosed with taurine deficiency and dilated cardiomyopathy, and to determine specific dietary associations. A second aim was to determine the whole blood taurine concentrations in a representative sample of healthy

Melanoma Is a Disease of Office Workers

Wednesday, December 12, 2018 -- In this interview with the late Dr. Robert Heaney, Creighton University professor of medicine and renowned researcher in the field of bone biology and vitamin D,1 he admits that an embarrassing secret in the field of nutrition is the lack of knowledge of what is really normal. When the approach to measuring vitamin intake is determining the amount needed to avoid triggering a disease or establishing the highest amount before you experience toxicity, then you don’t achieve what is optimal to support biological function. Vitamin D is a steroid hormone your body produces with the help of cholesterol when you're exposed to the sun. This critical nutrient interacts with a number of different systems in your body and is

Regular theatre and cinema visits keeps depression away in seniors finds study

Monday, December 17, 2018 -- A new study has shown that elderly who are regulars at the cinema, theatre or spend time at cultural meets and activities can protect themselves from depression. The study results were published in the latest issue of the journal British Journal of Psychiatry.

Spilling the Beans: How Much Caffeine is Too Much?

Wednesday, December 12, 2018 -- In what foods is caffeine found? Can caffeine pose a danger to your health? This Consumer Update answers these and other key questions about caffeine.

J&J; says its psoriasis drug superior to Novartis' in study

Wednesday, December 12, 2018 -- Johnson & Johnson said its drug Tremfya was found to be more effective than a rival medicine from Novartis AG in reducing the severity and affected area in adults with moderate-to-severe plaque psoriasis in a late-stage study.

Indivior wins fresh hold on Dr. Reddy's Suboxone copy

Wednesday, December 12, 2018 -- Indivior Plc has secured another hold on the launch of a generic competitor to its best-selling opioid addiction drug in the United States, the London-listed company said on Wednesday.

Johnson & Johnson’s Tremfya tops Novartis blockbuster Cosentyx in head-to-head psoriasis showdown

Wednesday, December 12, 2018 -- Johnson & Johnson’s Tremfya may have made its debut after key rivals, but it made waves Wednesday in the next-gen psoriasis field with Cosentyx-topping head-to-head data. So much so that rival Novartis felt the need to host its own Cosentyx-defending press call.

4MGS Test Predicts IPF Patient Mortality, Hospitalization, Study Says

Wednesday, December 12, 2018 -- Gait speed, measured by the four meter gait speed (4MGS) test, is an independent predictor of all-cause mortality and hospitalization in patients with idiopathic pulmonary fibrosis (IPF), according to a recent study. The tool could be used as a prognostic approach to select cohorts in clinical trials, optimize trial endpoints, and identify high-risk patients. The […] The post 4MGS Test Predicts IPF Patient Mortality, Hospitalization, Study Says appeared first on Pulmonary Fibrosis News.

Lilly says Taltz superior to Humira in late-stage psoriatic arthritis trial

Monday, December 17, 2018 -- Eli Lilly and Co said on Monday its psoriatic arthritis drug, Taltz, was found to be more effective than the world's best-selling prescription medicine, AbbVie Inc's Humira, in a late-stage trial.

Regular trips out guard against depression in old age

Thursday, December 13, 2018 -- New study from The British Journal of Psychiatry finds clear link between cultural engagement and lower risk.

Herceptin Biosimilar Herzuma Approved for Certain Breast Cancer Indications

Monday, December 17, 2018 -- Celltrion and Teva announced that the FDA has approved Herzuma (trastuzumab-pkrb) injection, a new biosimilar to Herceptin (trastuzumab; Genentech) for certain HER2-overexpressing breast cancer indications.

Low-birth-weight infants at increased risk for malaria

Monday, December 17, 2018 -- Infants who were born with a low birth weight for their gestational age were approximately two times more likely to have malaria infection or clinical malaria compared with infants born at a normal weight, according to research published in The Journal of Infectious Diseases.“Small birth weight for gestational age, or SGA, is commonly used as a proxy for intrauterine growth restriction,” Gino Agbota, from the University of Paris, and colleagues wrote. “SGA is estimated to have affected 32.4 million newborns in low- and middle-income countries, with sub-Saharan Africa

Could a once-abandoned obesity drug be revived in osteoporosis?

Thursday, December 13, 2018 -- Irisin, the once much-hyped but controversial “exercise hormone” that researchers had hoped would be an effective obesity treatment, could make a comeback—this time in bone strengthening.

Osteoporosis screening guidelines fail to identify fracture risk in younger postmenopausal women

Wednesday, December 12, 2018 -- Current osteoporosis screening and treatment guidelines in the United States and Canada have low sensitivity for identifying younger postmenopausal women who subsequently experience major osteoporotic fracture, according to findings published in the Journal of Bone and Mineral Research.The U.S Preventive Services Task Force screening guide for osteoporosis recommends the use of a formal clinical risk assessment tool for postmenopausal women aged 50 to 64 years to identify candidates for bone mineral density testing, whereas the Canadian strategy recommends BMD testing in women with specific

IgA vasculitis linked to higher risk for hypertension, chronic kidney disease

Monday, December 17, 2018 -- Patients with IgA vasculitis, also known as Henoch-Schönlein purpura, are at an increased risk for hypertension and chronic kidney disease compared to those without the condition, according to recent findings in the Annals of the Rheumatic Diseases.“IgA [vasculitis] may be complicated by glomerulonephritis and it is thought that adult-onset IgA [vasculitis] is associated with increased risk and severity of renal involvement compared with childhood disease,” Lorraine Harper, PhD, MRCP, of the University of Birmingham, in the United Kingdom, and colleagues wrote. “However,

Genetics study offers hope for new acne treatment

Wednesday, December 12, 2018 -- A discovery by researchers from the School of Basic & Medical Biosciences and NIHR Guy's and St Thomas' Biomedical Research Centre could lead to new treatments for severe acne. Scientists found 15 genome regions linked to developing the condition.

New 'epigenetics-based' cervical cancer test outperforms Pap smear and HPV tests

Monday, December 17, 2018 -- A new test for cervical cancer was found to detect all of the cancers in a randomized clinical screening trial of 15,744 women, outperforming both the current Pap smear and human papillomavirus test at a reduced cost, according to a study led by Queen Mary University of London.

A Web-Based Coping Intervention by and for Parents of Very Young Children With Type 1 Diabetes: User-Centered Design

Monday, December 17, 2018 -- Background: Management of type 1 diabetes (T1D) among children aged <6 years is exceptionally challenging for parents and caregivers. Metabolic and psychosocial outcomes among very young children with T1D (YC-T1D) are tightly associated with their parents’ ability to meet these challenges. There is scant research testing interventions targeting these issues and few resources to equip health care providers with feasible and effective coping strategies for these parents. User-centered design (UCD) of a continuously accessible Web-based resource could be a mechanism for helping parents of YC-T1D cope more effectively with the complex challenges they face by providing them with information, solutions, and emotional support. Objective: The objectives of this paper are to (1) describe the application of UCD principles to

Does Treatment with Vitamin D Reduce Cardiovascular Risk in Hemodialysis Patients?

Wednesday, December 12, 2018 -- To our surprise, the risk of cardiovascular event tended to be higher in the patients who continued treatment with active vitamin D than those who continued non-use of active vitamin D, although the difference was not statistically significant. Continue reading →

Novel Subtypes in B Progenitor Acute Lymphoblastic Leukemia

Wednesday, December 12, 2018 -- MedicalResearch.comInterview with: Zhaohui Gu, PhDPostdoctoral Research Associate St. Jude Children’s Research Hospital, TN  What is the background for this study?  What are the main findings? Response:B-progenitor acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy and the leading cause of … Continue reading →