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Why it's used

Celecoxib is used to relieve the condition of inflammation of joints due to degeneration of cartilage tissue (osteoarthritis) and a long-term stage of inflammation of the joints (rheumatoid arthritis). This medicine is also used to relieve the condition of inflammation and stiffness in joints in children of age group 16 years or younger (juvenile rheumatoid arthritis) and a form of inflammatory arthritis that affects the spine and large joints (ankylosing spondylitis). It is a prescription medicine. This medicine works by stopping the body's production of natural substances that cause pain and inflammation. Celecoxib is also used for the management of acute pain. It is also used to treat pain just before or during menstrual periods. Celecoxib is also used to reduce the incidence of abnormal tissue growth (polyps) formation in an inherited disorder of the large intestine.
When not to use
Celecoxib should not be used to treat worsening of symptoms of asthma (asthma attack), hives, or other allergic reactions with aspirin or any other NSAID medicine. Celecoxib should not be used to treat pain before or after the heart surgery.
Nonsteroidal Anti-inflammatory Drugs
Celecoxib belongs to a class of medicines called Nonsteroidal Anti-inflammatory Drugs. Nonsteroidal anti-inflammatory drugs, also called as NSAIDs, help reduce fever, decrease pain, and prevent clotting of blood. NSAIDs also reduce inflammation in the body when used in higher doses.

How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Celecoxib. If you have any questions related to this medicine, ask your doctor or pharmacist. Eat this medicine as recommended by your doctor.
Celecoxib is eaten with or without food.
The typical dose of Celecoxib is 100 mg twice daily. The usual dose for children is 50-100 mg twice daily. The maximum adult dose of Celecoxib is 400 mg in a day. Celecoxib is commonly used at the same time every day.
This medicine should be used on an as-needed basis.
Talk to your doctor if you develop new or worsening symptoms. Tell your doctor if nausea, more tired or weaker than usual, itching, yellow skin or yellow eyes, stomach pain, flu-like symptom, vomit blood, blood in bowel movement, skin rash, unusual weight gain, and swelling of the arms and legs, hands and feet. If you have issues with the health of your liver, the daily dose of Celecoxib should be reduced to half in patients with moderate dysfunctioning of the liver.
Older patients may see an increase in the incidence of side-effects with this medicine. As a result, a lower dose may be recommended for older patients.
If you are giving Celecoxib to a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child's weight or age to find the right dose from the product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
Consult with your doctor on the consumption of alcohol with Celecoxib.
You should store Celecoxib 15-30°C (59-86°F), and away from moisture. Store the medicine away from the reach of children and pets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Celecoxib for conditions for which it was not prescribed. Do not give Celecoxib to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

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How to take Celecoxib

Your dose and how often you take Celecoxib will depend on the following factors:
  • age
  • weight
  • patient's health
  • the health of the patient's kidneys
  • medicines recommended by the doctor
  • any other medicines being used
  • herbal supplements in use
  • response to the medicine

Celecoxib Dosage

Dosage for inflammation of joints due to degeneration of cartilage tissue (osteoarthritis)

  • Recommended: 200 mg/day as a single dose or 100 mg twice a day

Dosage for long-term inflammation of the joints (rheumatoid arthritis)

  • Recommended: 100 to 200 mg twice a day

Dosage for inflammation of joint and stiffness in a child of 16 years age or younger (juvenile rheumatoid arthritis)

Children (children of 2 years age and older with a body weight of 10 kg to 25 kg (22 lb to 55 lb))
  • Recommended: 50 mg twice a day
Children (children of 2 years age and older with a body weight more than 25 kg (55 lb))
  • Recommended: 100 mg twice a day

Dosage for inflammatory arthritis that affects the spine and large joints (ankylosing spondylitis)

  • Recommended: 200 mg daily once a day or 100 mg twice daily. If no result is observed after six weeks, a trial of 400 mg dose is given on a daily basis and again if no impact is seen after six weeks at a dose of 400 mg daily, should be transferred to alternative therapy.

Dosage for acute pain in adults and pain just before or during menstrual periods (Primary dysmenorrhea)

  • Recommended: 200 mg twice a day
  • Initial: 400 mg a day, followed by an additional 200 mg if required

Dosage for abnormal tissue growth (polyps) formation in an inherited disorder of the large intestine

  • Recommended: 400 mg twice a day with regard to food

Minimum Age

2 years

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.


Strength: 50 mg, 100 mg, 200 mg, 400 mg

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed dose.


What to do if you overdose on Celecoxib?
In case of overdose, symptomatic (treatment according to symptoms) and supportive care should be provided.
Symptoms of an overdose of Celecoxib
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
  • acute kidney damage
  • bleeding in the stomach and intestine
  • breathing disorder
  • high blood pressure
  • lack of energy
  • life-threatening allergic reaction
  • nausea
  • pain below the ribs in the area of the upper abdomen (epigastric pain)
  • sleepiness (drowsiness)
  • unconsciousness (coma)
  • vomiting
If you think you have overdosed on Celecoxib, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at

Precautions while using Celecoxib

Before you use Celecoxib, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Discuss with your doctor if you are allergic to aspirin, ibuprofen, naproxen, or sulfa medicines.
Before you use Celecoxib, tell your doctor of your medical history including stomach and intestinal bleeding, stomach ulcer disease, allergic reaction to sulfonamides, breathing disease (asthma), aspirin-sensitive asthma, liver disease, kidney disease, inflammatory disease of the intestines (ulcerative colitis or Crohn’s disease), or heart disease. Before having any surgery, discuss with your doctor and dentist about medicines you use including prescription medicines, non-prescription medicines, and herbal supplements.
The use of Celecoxib may change thromboplastin time. Celecoxib may prolong the partial thromboplastin time.
The use of this medicine may change lithium. The use of Celecoxib may increase the levels of lithium in the blood.
The use of Celecoxib may change blood pressure. Celecoxib may increase the blood pressure level.
The use of this medicine may change blood uric acid. The use of Celecoxib may increase the blood uric acid level.
The use of this medicine may change blood glucose. The level of blood glucose has been found to be increased with the use of Celecoxib.
Celecoxib is not for use by women. Hence women who are pregnant should not use this medicine. The use of Celecoxib during the second or third trimester of pregnancy may cause fetal kidney dysfunction. Celecoxib belongs to the NSAID class of medicines. NSAIDs should not be taken after 29 weeks of pregnancy as these medicines may cause serious harm to the unborn baby. Women who are breastfeeding should not use this medicine. Low level of medicine may pass into breast milk. The use of Celecoxib is not recommended in women who are attempting to conceive.
Consult with your doctor if you can drink alcohol while using Celecoxib. Consumption of alcohol may cause may increase risk of stomach and intestinal bleeding.
Celecoxib can make you feel sleepy. Be careful, especially while driving, while using heavy machinery, or when doing any activity that needs you to be completely alert. The consumption of alcohol with Celecoxib can worsen the sleepiness.
This medicine may cause stomach bleeding. Regular use of tobacco and alcohol may increase your risk. Discuss with your doctor if you smoke and drink alcohol regularly. This medicine may increase your sensitivity to sunlight and make you prone to sunburn. If this happens, limit your time outdoors to prevent sunburn. Use a sunscreen and cover your skin when you are outdoors. If you get sunburns on your body, consult with your doctor.
Older patients may have a higher incidence of side-effects when using Celecoxib. Elderly patients may see an increased risk of kidney failure, and stomach and intestine events.
Prolonged use of Celecoxib may result in kidney injuries (kidney papilla cell damage), stomach and intestine problems (ulcers and bleeding in the stomach and intestines), heart disease, or it may lead to other fatal conditions.

Celecoxib Side-effects

The following side-effects may commonly occur when using Celecoxib. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use of Celecoxib may cause the following side-effects:
The following severe side-effects may also occur when using Celecoxib:
  • psychiatric disorders
    Symptoms: insomnia, anxiety, depression, confusional state hallucinations
  • metabolism and nutrition disorders
    Symptoms: high level of potassium in the blood
  • immune system disorders
    Symptoms: severe potentially life-threatening allergic reaction
  • blood and lymphatic system disorders
    Symptoms: decrease in the total amount of red blood cells, decrease in the number of white blood cells (leukopenia), low levels of thrombocytes, deficiency of red cells, white cells and platelets (pancytopenia)
  • infections and infestations disorders
    Symptoms: swelling of the tissue lining the sinuses (sinusitis), upper respiratory tract infection, inflammation of the pharynx (pharyngitis), urinary tract infection inflammation of the larynx (laryngitis)
  • nervous system disorders
    Symptoms: dizziness, increased muscle tone (hypertonia), headache, lack of blood supply to the brain (cerebral infarction), loss of body movements, decrease taste sensitivity, bleeding occurs inside the skull (intracranial hemorrhage), inflammation of the linings of the brain (aseptic meningitis) disturbed nerve cell activity (epilepsy)
  • eye disorders
    Symptoms: inflammation of the conjunctiva (conjunctivitis), eye bleeding, blockage of the retinal artery blockage of a retinal vein
  • ear and labyrinth disorders
    Symptoms: hearing loss (hypoacusis)
  • heart disorders
    Symptoms: heart attack, heart failure, increased heartbeat, irregular heartbeat, unstable angina, leakage of the aortic valve each time the left ventricle relaxes (aortic valve incompetence), hardening of the arteries (coronary artery atherosclerosis), slow heartbeat (sinus bradycardia), thickening of the heart muscle (ventricular hypertrophy) heart rhythm disorder (ventricular fibrillation)
  • vascular disorders
    Symptoms: sudden blockage in a lung artery (pulmonary embolism), inflammation of the blood vessels (vasculitis), high blood pressure a blood clot in a deep vein (deep vein thrombosis)
Your doctor has prescribed this Celecoxib because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Celecoxib.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at


Corticosteroids therapy

The use of Celecoxib cannot be expected to be a substitute in order to treat corticosteroid insufficiency. On the other hand, an abrupt discontinuation of corticosteroids may result in exacerbation of corticosteroid-responsive illness. Patients on prolonged treatment with corticosteroids should have their therapy reduced slowly if a decision is made to discontinue corticosteroids.

Pregnant women

Patients who are in their late pregnancy, usually starting at 30 weeks gestation are at an increased risk when using this drug. The use of Celecoxib should be avoided during pregnancy as it may cause premature closure of ductus arteriosus, which is a blood vessel that connects the major pulmonary artery to the descending aorta in an unborn child. Celecoxib should be used during pregnancy only if the potential benefit outweighs the potential risk to the unborn baby.

Skin reactions

Patients using Celecoxib may see an increased risk of serious skin side effects such as exfoliative dermatitis and Stevens-Johnson syndrome (SJS) which can be fatal. These severe side-effects can occur without any warning and in patients without known previous allergy to sulfa drugs. Patients should be notified about the signs and symptoms of severe skin reactions, and use of the drug should be withdrawn during the first appearance of skin rash or any other sign of allergic reaction.

Allergic reactions

Patients taking Celecoxib are at increased risk of allergic reactions (swelling of the lower layer of the skin). Celecoxib should not be given to patients with the symptoms of aspirin intolerance. This symptom complex typically occurs in patients who have inflammation of airways of lungs (asthma), with rhinitis with or without painless growth on the lining of the nose (nasal polyps), or who display severe and potentially fatal bronchospasm after taking aspirin or other NSAIDs. Emergency help should be given in cases where such allergic reactions occur.

Kidney disease

Use of Celecoxib in patients with abnormal functioning of the kidney may lead to an increased risk of kidney damage. In such patients, taking NSAID's may cause a dose-dependent reduction in the formation of prostaglandins and, secondly, in kidney blood flow, which may precipitate the inability of kidneys to compensate for the overload of organ failure. Treatment with Celecoxib should not be used in patients with advanced kidney disease. If therapy with Celecoxib must be started, close monitoring of the functioning of kidneys of the patient is recommended.

Liver abnormalities

Patients taking Celecoxib may have increased risk of severe liver reactions, including jaundice and liver function problems and liver damage with fatal outcome. Careful monitoring of the patients should be done for the occurrence of severe liver reactions while on the treatment with Celecoxib.

Stomach and intestinal events

Use of Celecoxib in patients may produce severe stomach and intestinal effects including bleeding, ulceration, and formation of holes all the way through the stomach, small intestine or large intestine, which can be fatal. Extreme care is recommended when Celecoxib is taken by patients with a prior history of ulcer disease or gastrointestinal bleeding.

Patients with heart failure and swelling of the various parts of the body

Patients taking Celecoxib may see an increased risk of swelling and excess fluid build up inside the body (fluid retention). Take necessary precautions while using Celecoxib in such patients.

Patients with high blood pressure

Patients taking thiazide or loop diuretics are at an increased risk to experience any damaging response when taking Celecoxib. The use of Celecoxib in such patients can lead to the development of high blood pressure or may worsen the existing high blood pressure both of which may increase the incidence of heart diseases. Proper care and monitoring of the blood pressure should be considered while initiating and undergoing the treatment with Celecoxib in such patients.

Blood clot inside a blood vessel of the heart

With the long-term use of Celecoxib, there is an increased risk of formation of a blood clot inside the blood vessel of the heart (severe heart related thrombotic events), heart attack and brain damage, which may be fatal. Patients should be advised for lowering the useful doses of Celecoxib for the shortest duration with the intention of individual patient therapy.

Blood related disorders

Patients on long-term treatment with Celecoxib may exhibit the signs or symptoms of insufficient production of red blood cells (anemia) or blood loss conditions.

Blood clot formation throughout the body (disseminated intravascular coagulation)

Patients with an age group of 16 or older are at an increased risk when using this medicine. Celecoxib should only be used with caution in children with systemic onset of inflammation of the joints (rheumatoid arthritis) due to the risk of blood clot formation throughout the body (disseminated intravascular coagulation).

Existing condition of narrowing of the airways of lungs (asthma)

Patients with the existing condition of asthma who are undergoing treatment with Celecoxib are at an increased risk when using this medicine. The use of aspirin in patients with aspirin-sensitive asthma may lead to the severe condition of tightening of the muscles of the lungs (bronchospasm), which can be fatal. Celecoxib should not be used in patients with this form of aspirin sensitivity.

Laboratory tests

Due to the severe risk of stomach and intestinal ulcerations and bleeding without any warning symptoms, the doctor should monitor for the signs and symptoms of stomach and intestinal bleeding. Patients who are on long-term treatment with NSAIDs should undergo complete blood count, and a chemistry profile checked regularly. If abnormal liver tests or kidney tests continue or worsens, the use of Celecoxib should be discontinued.

Inherited disorder which is characterized by cancer of the large intestine and rectum (stomach and intestinal cancer in familial adenomatous polyposis)

Treatment with Celecoxib has not been shown to diminish the risk of stomach and intestinal cancer or the need for a surgical procedure as a preventive measure or other related surgeries. Therefore, the care of such patients should not be changed because of the usage of Celecoxib. In particular, the frequency of routine endoscopic examination should not be reduced, and surgery as a preventive measure or other related surgeries should not be delayed.

Interactions with Celecoxib

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Your doctor's guidelines may need to be followed while taking this medicine along with angiotensin converting enzymes inhibitors and angiotensin II antagonists, which are used for the treatment of high blood pressure. Reports have suggested that NSAIDs may decrease the blood pressure lowering effect of angiotensin converting enzyme (ACE) inhibitors and angiotensin II antagonists. This interaction should be considered in patients who are taking Celecoxib in combination with ACE-inhibitors and angiotensin II antagonists.
Celecoxib interacts with lithium, which is used for the treatment of depressive disorders. The use of Celecoxib along with lithium has shown to increase the levels of lithium in blood in patients who were receiving lithium at a dose of 450 mg twice a day with Celecoxib 200 mg twice a day in comparison to subjects receiving lithium alone. Patients who are on treatment with lithium should be monitored closely when the treatment with Celecoxib is initiated or withdrawn.
There may be an interaction of Celecoxib with warfarin, which is used as an anticoagulant to prevent clotting of blood. Post-marketing reports have revealed severe bleeding events, some of which were fatal, particularly in the elderly, in association with an increase in the time taken by blood to clot (prothrombin time) in patients taking Celecoxib in combination with warfarin. The monitoring of anticoagulant activity should be done, particularly during the first few days, after beginning or changing Celecoxib therapy in patients who are on treatment with warfarin or similar agents, since these patients are at an enhanced risk of bleeding problems.
Celecoxib may interact with CYP2C9 inhibitors, which are the drugs that block the enzyme CYP2C9. Celecoxib is metabolized predominantly by cytochrome CYP2C9 in the liver. Significant interactions may occur when Celecoxib is given in combination with drugs that prevent CYP2C9 enzyme. The use of Celecoxib and drugs that are known to block the working of enzyme CYP2C9 should be done with caution.
Special instructions need to be followed while taking this medicine along with aspirin, which is used for the treatment of pain, fever, and inflammatory conditions. The use of Celecoxib with aspirin can be done at low-dose. However, the use of aspirin with Celecoxib increases the rate of stomach and intestinal ulceration or bleeding, or other complications as compared to the use of Celecoxib alone. Because of the lack of platelet effects of Celecoxib, it cannot be used as a substitute of aspirin for prevention of heart problems. When these drugs are used together, the doctor and patients should remain alert for the development of such events, even if there was no history of heart problems. Patients should also be informed about the signs and symptoms of harmful effects on the heart and the steps to take if any such symptom occurs. If the therapy with Celecoxib is initiated, close monitoring of the functioning of kidneys is advisable.
Celecoxib interacts with ciclosporin and tacrolimus, which are used as immunosuppressants. The combined use of Celecoxib with NSAIDs and ciclosporin or tacrolimus may enhance the damaging effects on kidneys by ciclosporin or tacrolimus, respectively. Proper monitoring of the functioning of kidneys is required when Celecoxib is used in combination with ciclosporin or tacrolimus.
Special instructions need to be followed while taking this medicine along with CYP2D6 blockage. Celecoxib is an inhibitor of CYP2D6. The level of medicinal products that are substrates of this enzyme may be enhanced when Celecoxib is taken in combination. Examples of drug products which are metabolized by CYP2D6 are antidepressants (tricyclics and SSRIs), neuroleptics, drugs used to treat abnormal heartbeat, etc. The dose of CYP2D6 substrates needs to be decreased when treatment with Celecoxib is initiated or increased or if treatment with Celecoxib is stopped.
There may be an interaction of Celecoxib with NSAID's, which are used to treat pain, fever, and inflammation. The use of Celecoxib and NSAID's has been associated with an increased risk of stomach and intestinal ulceration or other complications as compared to the use of Celecoxib alone. The use of Celecoxib together with NSAID's at any dose should be avoided due to the potential for enhanced risk of side-effects.
Celecoxib may interact with furosemide, which is used for the treatment of high blood pressure. It has been shown that NSAIDs can reduce the sodium excreting effect of furosemide and thiazides in some patients. This response is due to the prevention of the synthesis of prostaglandins in the kidney.
This page does not contain all the possible interactions of Celecoxib. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Celecoxib is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Celecoxib .
Rheumatoid Arthritis
Ankylosing Spondylitis

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