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Why it's used

Cephradine is used to treat respiratory bacterial infections such as sinus infection, inflammation of the pharynx and tonsil, swelling inside the trachea with bronchial inflammation, middle ear infection, and pneumonia with bronchial inflammation. It can also be used to treat urinary tract and skin and soft tissue infections. This medicine works by preventing the synthesis of the bacterial cell wall. Cephradine is also used to prevent the risk of infections after operations and also for patients with decreased body defense against bacterial infections.
Cephalosporin Antibacterials
Cephradine is a prescription medicine that belongs to a class of medicines called Cephalosporin Antibacterials. Cephalosporin antibacterials are an antibiotic class of medicines which are used to treat bacterial infections such as kidney and urinary tract infections, respiratory tract infections, and skin infections.

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How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Cephradine. If you have any questions related to this medicine, ask your doctor or pharmacist. Eat this medicine as recommended by your doctor.
Cephradine is eaten with or without food. Take Cephradine with food to prevent stomach upset. This medicine should be swallowed with a glass of water.

Typical Dosage

The typical dose of Cephradine is 250-500 mg four times daily or 500-1000 mg twice daily based on the patient's condition. The usual dose for children is 25-50 mg/kg/day (11.4-22.7 mg/lb/day) in two or four equally divided doses.
This medicine is to be used for longer periods of time. This medicine may be given for long-term use for complications such as inflammation of the epididymis and prostate gland. You should continue to use this medicine as directed by the doctor even if you feel well.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.

Talk to Your Doctor

Talk to your doctor if you develop new or worsening symptoms. Tell your doctor if bloody diarrhea, blistering or peeling of the skin, swelling of the lips, face, and tongue, tightness of the chest, difficulty breathing, feeling faint, and itchy skin. If you have any kidney disease, amount and time interval of a dose of Cephradine may depend on the functioning of the kidney. If you have issues with the health of your liver, the functioning of the liver should be monitored, and modifications of doses may be required.

Use in Children

If you are giving Cephradine to a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child's weight or age to find the right dose from the product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Storage

You should store Cephradine below or at 25°C (77°F). Store the medicine away from the reach of children and pets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Cephradine for conditions for which it was not prescribed. Do not give Cephradine to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

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How to take Cephradine

Your dose and how often you take Cephradine will depend on the following factors:
  • age
  • weight
  • patient's health
  • the health of the patient's liver
  • the health of the patient's kidneys

Cephradine Dosage

Dosage for respiratory tract infections

Adult
  • Recommended: 250-500 mg four times daily or 500-1000 mg twice daily based on the patient's condition
Children
  • Recommended: 25-50 mg/kg/day (11.4-22.7 mg/lb/day) in two or four equally divided doses
Older Adults
  • Recommended: 250-500 mg four times daily or 500-1000 mg twice daily based on the patient's condition

Dosage for skin and soft tissue infections

Adult
  • Recommended: 250-500 mg four times daily or 500-1000 mg twice daily based on the patient's condition
Children
  • Recommended: 25-50 mg/kg/day (11.4-22.7 mg/lb/day) in two or four equally divided doses
Older Adults
  • Recommended: 250-500 mg four times daily or 500-1000 mg twice daily based on the patient's condition

Dosage for urinary tract infections

Adult
  • Recommended: 500-1000 mg twice daily based on the patient's condition
Children
  • Recommended: 25-50 mg/kg/day (11.4-22.7 mg/lb/day) in two or four equally divided doses
Older Adults
  • Recommended: 500-1000 mg twice daily based on the patient's condition

Dosage for middle ear infection

Children
  • Recommended: 75-100 mg/kg (34.1-45.5 mg/lb) in divided doses every 6-12 hours
  • Maximum: 4000 mg/day

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Capsule, Gelatin Coated
Strength: 250 mg and 500 mg
Suspension
Strength: 125 mg/5 ml and 250 mg/5 ml

Special Instructions

Creatinine clearance more than 20 ml/min
Patients with creatinine clearance of kidney more than 20 ml/min should take 500 mg of Cephradine every 6 hours.
Creatinine clearance in between 5-20 ml/min
Patients with creatinine clearance between 5-20 ml/min should take 250 mg of Cephradine every 6 hours.
Creatinine clearance less than 5 ml/min
Patients with creatinine clearance of kidney less than 5 ml/min should take 250 mg of Cephradine every 12 hours.
Patients on dialysis
250 mg dose of Cephradine should be given at the start of hemodialysis, 6-12 hours after the start of dialysis, and 36-48 hours after the start of dialysis. At the start of next hemodialysis, 250 mg of Cephradine should be given if there will be more than 30 hours of the previous dose.

Missed Dose

If you missed a dose, take it as soon as you remember. Skip the missed dose if it's time for the next dose. Avoid taking a double dose to make up for the missed dose.

Overdose

What to do if you overdose on Cephradine?
In case of overdose, supportive treatment should be given, and stomach emptying (gastric lavage) is required if a large amount of drug is ingested.
Symptoms of an overdose of Cephradine
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Cephradine, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Cephradine

Before you use Cephradine, tell your doctor of your medical and health history including the following:
  • Lapp lactase deficiency
  • abnormal absorption of glucose-galactose
  • diabetes
  • galactose intolerance
  • kidney problems
Patients with kidney problems may require a low dose. While using this medicine in diabetic patients, the use of chemicals to check the sugar level in urine may give false positive results.
Before you use Cephradine, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic any of the following substances: penicillin antibiotics.
The use of this medicine may change liver enymes levels. This medicine may enhance the level of liver enzymes (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphate).
The use of Cephradine may change bilirubin level. The levels of total bilirubin may get increase by taking this medicine.
The use of this medicine may change blood urea nitrogen and creatinine levels. This medicine may raise the level of waste products (blood nitrogen urea, creatinine) in the blood.

Dizziness

Cephradine can make you feel sleepy. Be careful when using any machinery, driving a vehicle, or doing any other activity that needs you to be fully alert. The consumption of alcohol with Cephradine can worsen the sleepiness.

Use in Pregnancy

Consult with your doctor on the use of Cephradine during pregnancy, or if you are planning to become pregnant. Use of Cephradine should not be used during pregnancy mainly in the first three months of pregnancy unless considered necessary by the doctor.

Use while Breastfeeding

Consult with your doctor on the use of Cephradine during breastfeeding. Take necessary precautions while using Cephradine in breastfeeding women as Cephradine may pass into breast milk.

Use while Conceiving

Consult with your doctor on the use of Cephradine, if you are trying to conceive.

Long-term Use

The long term use of antibiotics may result in the overgrowth of unknown (non-susceptible) organisms.

Cephradine Side-effects

Rarely, the use of Cephradine may cause the following side-effects:
The following severe side-effects may also occur when using Cephradine:
  • Immune system disorders
    Symptoms: fever severe allergic reactions
  • Liver disorders
    Symptoms: stoppage of bile flow from the liver (cholestatic jaundice) increased level of liver enzymes
  • Stomach or intestinal disorder
    Symptoms: diarrhea vomiting
    In this case, inform your doctor.
  • Brain disorders
    Symptoms: confusion
    If this happens, contact your doctor.
  • Symptoms: abnormally low level of blood platelets, decreased amount of white blood cells, deficiency of all types of blood cells, when body stops producing enough new blood cells the abnormal breakdown of red blood cells
  • Infections
    Symptoms: antibiotic-associated inflammation of the colon an inflammation of the vagina (vaginitis)
  • Severe skin reactions
    Symptoms: skin rash, drug-induced severe allergic reaction, severe allergic reactions, swelling due to fluid accumulation difficulty breathing
    In such cases, stop using this medicine and contact with the doctor immediately.
  • Kidney disorders
    Symptoms: inflammation of the kidney, reduced urine output cloudy or bloody urine
    If this happens, contact your doctor.
Your doctor has prescribed this Cephradine because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Cephradine.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Genetic Problems

Patients with genetic problems including galactose intolerance, Lapp lactase deficiency or abnormal absorption of glucose and galactose are at increased risk when using this medicine. Such patients should not use this medicine.

Kidney Failure

Patients with kidney failure are at increased risk when using this medicine. A low dose of Cephradine should be used to prevent kidney failure.

Excessive Growth of Organisms

Patients who use this medicine for a long-term are at increased risk. Long term use of antibiotics may cause excessive growth of unknown (non-susceptible) organisms.

Laboratory Test

Patients using this medicine are at increased risk. There are increased chances of the occurrence of false positive reaction of glucose in the urine by Fehling's or Benedicts's solution or by reagent tablet for example Clinitest. It does not happen with enzyme-based tests like Clinistix or Diastix.

Interactions with Cephradine

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Cephradine. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Loop Diuretics

Cephradine may interact with loop diuretics, which are used to treat high blood pressure. Loop diuretics may increase the chances of kidney damage while taking with cephalosporins.

Uricosuric Agent

There may be an interaction of Cephradine with Uricosuric agent such as probenecid, which is used to lower the levels of uric acid. Probenecid increases the amount of Cephradine in the blood, by decreasing kidney clearance of the cephalosporins.

Antibiotic

Cephradine interacts with Antibiotic such as penicillin, which is used to treat bacterial infections. There are chances of allergy due to the combined use of penicillins and cephalosporins. Take necessary precautions while using Cephradine in patients with known allergy to penicillins.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Cephradine is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Cephradine .
Bacterial Infections
Pharyngitis
Ear Infection
Urinary Tract Infections

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