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Severe allergy

This medicine is not recommended in patients who have a severe allergy to Erythromycin. These patients may have the following symptoms if they use this medicine:
  • hives
  • mild skin eruptions
  • fainting
  • facial swelling
  • swelling of the lips
  • ulcers in the mouth
  • ulcers in the throat
  • allergic reaction (anaphylaxis)
  • redness of the skin (erythema multiforme)
  • severe skin reactions (Stevens-Johnson syndrome)
  • drug-related skin reaction (acute generalized exanthematous pustulosis)
  • difficulty in breathing
  • swelling of the throat
  • skin rash
  • severe skin reactions such as fluid-filled blisters, ulcers or sores

Patients taking astemizole, terfenadine, pimozide and cisapride

This medicine is not recommended in patients taking astemizole, terfenadine, pimozide, cisapride. The use of Erythromycin with terfenadine and astemizole may cause serious heart disorders such as abnormal prolongation of heartbeat (QT/QTc interval prolongation) and abnormal heartbeat originating from lower chambers of the heart. The use of Erythromycin with terfenadine can be possibly fatal. The use of Erythromycin with cisapride may cause prolonged heartbeat (QT prolongation), irregular heartbeat, increased heartbeat, abnormal heart rhythm (ventricular fibrillation) and can be possibly fatal.

Patients using ergotamine and dihydroergotamine

Erythromycin is not recommended in patients who are using ergotamine and dihydroergotamine. These patients may suffer from an increased amount of ergots in the blood. These patients may have the following symptoms if they use this medicine:
  • constriction of the blood vessels (vasospasm)
  • reduced blood supply to the body parts including brain

Patients using simvastatin

The use of Erythromycin with simvastatin is not recommended. The use of Erythromycin with simvastatin may increase the amount of simvastatin in the body. It may also cause muscle injury and leakage of protein content into the blood (rhabdomyolysis) with or without kidney problems.

Patients using tolterodine

The use of Erythromycin with tolterodine is not recommended.

Patients using mizolastine

The use of Erythromycin with mizolastine is not recommended. There is a risk of change in the breakdown of mizolastine while using with Erythromycin.

Patients using amisulpride

The use of Erythromycin with amisulpride is not recommended.

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