Get a month of TabletWise Pro for free! Click here to redeem 
TabletWise.com
 

Why it's used

Levofloxacin is used to treat pneumonia. Levofloxacin is also used to treat sinus infections, to treat severe cases of bronchitis, to treat certain other kinds of bacterial infections in the body, such as, on the skin, prostate, urinary tract, bladder and kidneys, and to treat certain potentially fatal infectious diseases, including, anthrax.
When not to use
Levofloxacin will not work against viral infections such as the common cold or flu.
Fluoroquinolone Antibacterial
Levofloxacin is a prescription medicine that belongs to a class of medicines called Fluoroquinolone Antibacterial. Fluoroquinolones are medicines used for the treatment and prevention of certain types of bacterial infections. These medicines are commonly used to treat respiratory and urinary tract infections.

Get TabletWise Pro

Thousands of Classes to Help You Become a Better You.

How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Levofloxacin. If you have any questions related to this medicine, ask your doctor or pharmacist. Use this medicine as recommended by your doctor.
Levofloxacin is used with or without food. Drink plenty of fluids while taking this medicine to avoid crystal formation in urine and formation of highly concentrated urine.

Typical Dosage

The typical dose of Levofloxacin is 250-750 mg every 24 hours. The usual dose for children is 8 mg per kg/3.5 mg per lb of weight every 12 hours with a maximum of 250 mg per dose. This medicine is typically used for a period of 7-14 days for pneumonia, 7 days for bronchitis, 28 days for swelling of the prostate, and 10 days for kidney infections. Levofloxacin is commonly used at the same time every day. This medicine is not known to be habit-forming.
This medicine should be used on an as-needed basis. You should continue to use this medicine as directed by the doctor even if you feel well.
The injection form of this medicine is to be slowly injected in the veins. The injection form of the medicine should not be used on the muscle, body cavity, spinal cord, or skin

Talk to Your Doctor

Talk to your doctor if you develop new symptoms. If you have any kidney disease, a lower dosage of Levofloxacin may be recommended if you suffer from kidney disease.

Use in Children

If you are giving Levofloxacin to a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child's weight or age to find the right dose from the product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Lab Tests

Your doctor may request that specific lab tests be performed before you start using Levofloxacin. You may need to have Antibiotic Susceptibility test. This test is required to determine the specific bacterial infection.

Storage

You should store Levofloxacin at 15-30°C (59°F to 86°F), away from excess moisture, and away from light. Store the medicine away from the reach of children and pets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Levofloxacin for conditions for which it was not prescribed. Do not give Levofloxacin to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

Get TabletWise Pro

Thousands of Classes to Help You Become a Better You.

How to take Levofloxacin

Your dose and how often you take Levofloxacin will depend on the following factors:
  • weight
  • patient's health
  • the health of the patient's liver
  • medicines recommended by the doctor
  • any other medicines being used
  • herbal supplements in use

Levofloxacin Dosage

Dosage for pneumonia from a hospital infection

Adult
  • Recommended: 750 mg every 24 hours for 7-14 days

Dosage for pneumonia not originating from a hospital

Adult
  • Recommended: 500 mg every 24 hours for 7-14 days or 750 mg every 24 hours for 5 days depending on the type of bacteria causing the infection

Dosage for severe cases of sinusitis

Adult
  • Recommended: 750 mg every 24 hours for 5 days or 500 mg every 24 hours for 10-14 days

Dosage for long-term bronchitis caused by infections

Adult
  • Recommended: 500 mg every 24 hours for 7 days

Dosage for skin infections (complicated)

Adult
  • Recommended: 750 mg every 24 hours for 7-14 days

Dosage for skin infections (uncomplicated)

Adult
  • Recommended: 500 mg every 24 hours for 7-10 days

Dosage for swelling of the prostate gland due to infections

Adult
  • Recommended: 500 mg every 24 hours for 28 days

Dosage for inflammation of the kidney and urinary tract infections

Adult
  • Recommended: 750 mg every 24 hours for 5 days or 250 mg every 24 hours for 10 days depending on the type of bacteria causing the infection

Dosage for inhalational anthrax

Adult
  • Recommended: 500 mg every 24 hours for 60 days
Children (less than 50 kg weight and more than or equal to 6 months of age)
  • Recommended: 8 mg per kg/3.6 mg per lb of weight every 12 hours for 60 days
  • Maximum: 250 mg per dose
Children (children more than 50 kg weight and more than or equal to 6 months of age)
  • Recommended: 500 mg every 24 hours for 60 days

Dosage for urinary tract infections (uncomplicated)

Adult
  • Recommended: 250 mg every 24 hours for 3 days

Dosage for inflammation of the urinary bladder

Adult
  • Recommended: 250 mg once daily for 3 days

Minimum Age

6 months

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablets
Strength: 250 mg, 500 mg, 750 mg
Oral Solution
Strength: 25 mg/mL
Injection: single-use vials for dilution
Strength: 500 mg in 20 mL, 750 mg in 30 mL
Injection: premix single-use flexible containers
Strength: 250 mg in 50 mL, 500 mg in 100 mL, 750 mg in 150 mL

Special Instructions

Oral Solution
Oral solution should be taken one hour before or two hours after the meal.
Injection
Injection should be infused into the veins slowly over a period of not less than 60 or 90 minutes.

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued.

Overdose

What to do if you overdose on Levofloxacin?
If you have taken more than the recommended dose of Levofloxacin get medical advice immediately. Antacids are recommended for the protection of the mucous membrane layer of the stomach.
Symptoms of an overdose of Levofloxacin
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Levofloxacin, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Levofloxacin

Before you use Levofloxacin, tell your doctor of your medical and health history including the following:
  • bone and joint problems
  • central nervous system problems
  • heart failure
  • heart transplant
  • high blood glucose
  • kidney problems
  • kidney transplant
  • liver problems
  • low potassium level in the blood
  • lung transplant
  • nerve problems
  • palpitations
  • seizures
  • slow heart rate
  • swollen and painful joints (rheumatoid arthritis)
  • tendon problems
Patients with kidney failure, rheumatoid arthritis, kidney, lung or heart transplant are at an increased risk of inflammation of the tissue connecting bone to muscle (tendinitis) and tendon rupture. Patients with a low potassium level in the blood, slow heart rate, or heart failure are at an increased risk of palpitations and loss of consciousness.
Before you use Levofloxacin, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
The use of Levofloxacin may change blood sugar. Using Levofloxacin with antidiabetic agents may cause either increase or decrease the blood sugar levels. Patients should be monitored carefully for blood glucose levels.
The use of this medicine may change blood clotting time. Using Levofloxacin with warfarin increases the bleeding episodes. Patients should be monitored for the blood clotting parameters (the international normalized ratio (INR), prothrombin time, or other anticoagulation tests) along with evidence of bleeding.

Seizures

Levofloxacin can make you feel sleepy. Be careful when using any machinery, driving a vehicle, or doing any other activity that needs you to be fully alert. The consumption of alcohol with Levofloxacin can worsen the sleepiness. Levofloxacin may cause rarely seizures in some people. If you perform any activities where a loss of consciousness may cause harm to you (or others), you should discuss with your doctor.

Use in Pregnancy

The use of Levofloxacin is known to be not safe for use in pregnant women. If you are planning to become pregnant or are currently pregnant, you should discuss with your doctor the potential impact of this medicine on the baby before you start to using it. There are not enough and well-controlled studies in pregnant women. This medicine should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.

Use while Breastfeeding

The use of Levofloxacin is not safe for use in women who are breastfeeding. If you are breastfeeding a baby, discuss with your doctor if you should either discontinue breastfeeding or stop using this medicine while breastfeeding. Levofloxacin may pass into breast milk which may cause serious side effects to infants. This medicine should be used only after considering the importance of the drug to the mother.

Use while Conceiving

Consult with your doctor on the use of Levofloxacin, if you are trying to conceive. Animal studies show that this medicine does not impact fertility. To be sure, discuss with your doctor.

Increased Risks

This medicine may increase your sensitivity to sunlight. If this happens, use a sunscreen and cover your skin when you are outdoors. Limit your time in the sun.

Side-effects in Older Patients

Levofloxacin may cause increased incidence of side-effects in older patients. Elderly patients may see an increased risk of tendon disorders, inflammation of the tissue connecting bone to muscle (tendinitis), inflammation of the liver (hepatitis), heart rhythm disorders, and low level of potassium in the blood.

Side-effects in Children

Levofloxacin may cause an increased risk of side-effects in children. Children using this medicine may see an increased risk of pain in joints (arthralgia), arthritis, illness of the muscle connecting to the bone (tendon disorders), and walking abnormality.

Long-term Use

Clinical data for safety and effectiveness of using this medicine beyond 28 days in adults and beyond 14 days in children have not been confirmed.

Levofloxacin Side-effects

The following side-effects may commonly occur when using Levofloxacin. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use of Levofloxacin may cause the following side-effects:
The following severe side-effects may also occur when using Levofloxacin:
  • Changes in sensation and possible nerve damage (peripheral neuropathy) (permanent nerve damage)
    Symptoms: pain, burning, tingling, numbness weakness
    The patient should discontinue the medicine.
  • Intestine infection (pseudomembranous colitis) (possibly fatal)
    Symptoms: diarrhea, bloody stools, stomach cramps fever
    Call your doctor right away if you get these symptoms.
  • Serious allergic reactions (possibly fatal)
    Symptoms: hives, trouble breathing or swallowing, swelling of the lips, swelling of the tongue, swelling of the face, abnormal voice changes (hoarseness), rapid heartbeat, fainting, yellowing of the skin or eyes throat tightness
    This medicine should be discontinued.
  • Central nervous system effects
    Symptoms: seizures, hallucinations, restlessness, tremors, nervousness, confusion, depression, insomnia, nightmares, lightheadedness, feeling of fearful thoughts (paranoia) suicidal thoughts or acts
  • Liver damage (possibly fatal)
    Symptoms: nausea, vomiting, stomach pain, fever, weakness, itching, unusual tiredness, loss of appetite, light colored bowel movements, yellowing of the skin, yellowing of the whites of the eyes dark-colored urine
  • Serious heart rhythm changes (QT prolongation and torsades de pointes) (possibly fatal)
    Symptoms: abnormal heartbeat fainting
    Tell your doctor right away if you have an irregular or fast heartbeat or if you faint.
  • Changes in blood sugar
    Follow the doctor's instructions for how often to check the blood sugar. Stop taking Levofloxacin and call your doctor right away if you get low blood sugar and you have diabetes while taking Levofloxacin. Your medicine may need to be changed.
  • Sensitivity to sunlight (photosensitivity)
    Symptoms: sunburn blisters or swelling of the skin
    If you get any of these symptoms while taking Levofloxacin, call your doctor right away. If you have to be in sunlight, use a sunscreen and wear clothes and a hat that covers your skin.
  • Joint problems such as arthritis
    Symptoms: pain, swelling, or inflammation of a tendon weakness or inability to use one of the joint
    The medicine should be discontinued. In the case of children, tell your child’s doctor if they have any joint problems during or after treatment with Levofloxacin. Call your doctor right away at the first sign of tendon swelling, pain, or inflammation.
Your doctor has prescribed this Levofloxacin because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Levofloxacin.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Bacterial Infection in the Colon

Patients with a bacterial infection in the colon are at an increased risk when using this medicine. Such patients may experience worsening of the bacterial infection on using this medicine. Patients should discontinue this medicine on worsening of their infection.

Quinolones Drug Therapy

Patients taking quinolones drug are at an increased risk when using this medicine. These patients are at an increased risk of fatal allergic reactions (itching and swelling of the skin), sun-allergic reactions, seizure, loss of consciousness, and central nervous system effects such as convulsions, substance-induced mental disorder, confusion, depression and nightmares. Such patients should discontinue this medicine on the appearance of symptoms of neuropathy, sun-allergic reactions, hepatitis, central nervous system effects and at the first appearance of an allergic reaction. Treatment of serious allergic reaction include antihistamines, corticosteroids, pressor amines, epinephrine drug therapy along with oxygen, intravenous fluids, and airway management, as recommended by the doctor.

History of Tendon Disorders

Patients with a history of tendon disorders such as swollen and painful joints (rheumatoid arthritis) are at an increased risk when using this medicine. Such patients may have an increased risk of tendinitis and tendon rupture. Patients should discontinue this medicine on the occurrence of hepatitis, pain, inflammation, swelling, or tendon rupture. Patients should be advised to take rest at the first sign of tendon rupture and contact the doctor for changing their medicine.

Kidney Failure

Patients with kidney failure are at an increased risk when using this medicine. Such patients may have an increased risk of tendinitis and tendon rupture. Patients should discontinue this medicine on the occurrence of hepatitis, pain, inflammation, swelling, or tendon rupture. Patients should be advised to take rest at the first sign of tendon rupture and contact the doctor for changing their medicine.

Difficult Physical Activity

Patients performing a difficult physical activity are at an increased risk when using this medicine. Such patients may have an increased risk of tendinitis and tendon rupture. Patients should discontinue this medicine on the occurrence of hepatitis, pain, inflammation, swelling, or tendon rupture. Patients should be advised to take rest at the first sign of tendon rupture and contact the doctor for changing their medicine.

Lung Transplantation

Patients with lung transplants are at an increased risk when using this medicine. Such patients may have an increased risk of tendinitis and tendon rupture. Patients should discontinue this medicine on the occurrence of hepatitis, pain, inflammation, swelling, or tendon rupture. Patients should be advised to take rest at the first sign of tendon rupture and contact the doctor for changing their medicine.

Heart Transplantation

Patients with heart transplant are at an increased risk when using this medicine. Such patients may have an increased risk of tendinitis and tendon rupture. Patients should discontinue this medicine on the occurrence of hepatitis, pain, inflammation, swelling, or tendon rupture. Patients should be advised to take rest at the first sign of tendon rupture and contact the doctor for changing their medicine.

Kidney Transplantation

Patients with a kidney transplant are at an increased risk when using this medicine. Such patients may have an increased risk of tendinitis and tendon rupture. Patients should discontinue this medicine on the occurrence of hepatitis, pain, inflammation, swelling, or tendon rupture. Patients should be advised to take rest at the first sign of tendon rupture and contact the doctor for changing their medicine.

Patients Undergoing Corticosteroid Therapy

Patients taking corticosteroid drugs are at an increased risk when using this medicine. Such patients may have an increased risk of tendinitis and tendon rupture. Patients should discontinue this medicine on the occurrence of hepatitis, pain, inflammation, swelling, or tendon rupture. Patients should be advised to take rest at the first sign of tendon rupture and contact the doctor for changing their medicine.

Patients Over 60 Years

Elderly patients are at an increased risk when using this medicine. Such patients may have an increased risk of inflammation of the tissue connecting bone to muscle (tendinitis), tendon rupture, liver damage and prolonged heartbeat. Patients should discontinue this medicine on the occurrence of hepatitis, pain, inflammation, swelling, or tendon rupture. Patients should be advised to take rest at the first sign of tendon rupture and contact the doctor for changing their medicine.

Palpitations and Decreased Potassium Levels

Patients with palpitations and decreased levels of the potassium in the blood are at an increased risk when using this medicine. These patients are at an increased risk of drug-associated effects on the heartbeat while using this medicine. Such patients should not use this medicine.

Children

Children using Levofloxacin are at an increased risk when using this medicine. These patients are at increased risk of pain in joints, arthritis, tendon disorders and, a movement disorder.

Diabetic Patients

Patients with diabetes are at increased risk when using this medicine. These patients may experience either increase or decrease in their blood glucose levels. This medicine should be discontinued and suitable therapy has to be started in such patients.

Absence of a Bacterial Infection

Patients with absence bacterial infection are at an increased risk when using this medicine. These patients may experience ineffectiveness of medicine against bacteria.

Women

Women are at an increased risk when using this medicine. These patients are more sensitive to medicine-associated effects. Such patients should use this medicine cautiously.

Interactions with Levofloxacin

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Levofloxacin. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Antacids

Levofloxacin may interact with antacids containing calcium, magnesium, or aluminum, which are used to relieve heartburn, indigestion or an upset stomach. This medicine reduces the absorption of Levofloxacin. The patient should take antacids within the two-hour period before or after taking Levofloxacin.

Sucralfate

There may be an interaction of Levofloxacin with sucralfate, which is used to treat acid backflow from the stomach to food pipe (gastroesophageal reflux disease) and duodenal ulcers. This medicine reduces the absorption of Levofloxacin. Sucralfate should be taken within the two-hour period before or after taking Levofloxacin.

Metal Cations

Levofloxacin interacts with metal cations such as iron and magnesium. This medicine reduces the absorption of Levofloxacin. Metal cations should be taken within the two-hour period before or after taking Levofloxacin.

Multivitamins Containing Zinc

Special instructions need to be followed while taking this medicine along with multivitamins containing zinc, which is used to treat vitamin deficiency due to poor diet, certain illnesses, alcoholism, or during pregnancy. This medicine reduces the absorption of Levofloxacin. The patient should take multivitamins within the two-hour period before or after taking Levofloxacin.

Didanosine

Your doctor's guidelines may need to be followed while taking this medicine along with didanosine, which is used to control conditions caused by HIV/AIDS. This medicine reduces the absorption of Levofloxacin. Didanosine should not be taken within the two-hour period before or after taking Levofloxacin.

Warfarin

Levofloxacin may interact with warfarin, which is used to treat and prevent harmful blood clots. Levofloxacin increases the effects of warfarin. Patients should have blood tests such as prothrombin time, international normalized ratio and other suitable anticoagulation tests while using both medicines together.

Antidiabetic Agents

There may be an interaction of Levofloxacin with antidiabetic agents which are used to treat high blood glucose. Using Levofloxacin with antidiabetic agents may increase or decrease the blood glucose levels. When using both medicines together, it is recommended to monitor blood glucose carefully.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Levofloxacin interacts with nonsteroidal anti-inflammatory drugs, which are used to treat painful and stiff joints (osteoarthritis) and swollen and painful joints (rheumatoid arthritis). When Levofloxacin is used with NSAIDS, it may increase the risk of shaking body movements (convulsive seizures). It may also increase the risk of central nervous system stimulation which may lead to tremors, restlessness, nervousness, lightheadedness, confusion, hallucinations, feeling of fearful thoughts (paranoia), depression, nightmares, insomnia, and rarely suicidal thoughts or acts.

Theophylline

Special instructions need to be followed while taking this medicine along with theophylline, which is used to treat asthma and respiratory illness such as bronchitis. Using theophylline and fluoroquinolones together may increase the levels of theophylline in the blood which may lead to increased theophylline associated side effects. When Levofloxacin is used with theophylline, the levels of theophylline should be monitored and appropriate dosage adjustments should be made.

Urine Screening Test

Your doctor's guidelines may need to be followed while taking this medicine along with a urine test. False positive urine screening tests for opiates have been reported in patients who were receiving fluoroquinolones. Another confirmatory test should be conducted to verify the results.

Probenecid

Levofloxacin may interact with probenecid, which is used to treat red, painful, hot, and swollen joints (gout) and increased uric acid in the blood (hyperuricemia). When Levofloxacin is used with probenecid, it decreases the elimination of Levofloxacin from the body. Patients should be cautious when Levofloxacin is used with probenecid.

Cimetidine

There may be an interaction of Levofloxacin with cimetidine, which is used to treat ulcer and gastroesophageal reflux disease. It interferes with the elimination of Levofloxacin. Patients should be cautious when Levofloxacin is used with cimetidine.

Cyclosporine

Levofloxacin interacts with cyclosporine, which is used to prevent organ rejection in liver, kidney, or heart transplant. When Levofloxacin is used with cyclosporine, it may increase the level of cyclosporine in the blood.

QT Interval Prolongation Drugs

Special instructions need to be followed while taking this medicine along with Drugs known to prolong QT interval (tricyclic antidepressants, macrolides, and antipsychotics). It results in the prolongation of the heartbeat (prolong QT interval). Patients should be cautious when Levofloxacin is used with the drugs that cause prolonged heartbeat.

Antiarrhythmic Agents

Your doctor's guidelines may need to be followed while taking this medicine along with antiarrhythmic agents (quinidine, procainamide, amiodarone, sotalol), which are used to treat abnormal heart rhythms. When Levofloxacin is used with antiarrhythmic agents, it may cause palpitations. Patients should avoid taking both drugs together.

Brands

Following are the top brand names of Levofloxacin in countries around the world:

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Levofloxacin is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Levofloxacin .
Bacterial Infections
Pneumonia
Sinusitis
Bronchial Disorders

Sign Up