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Why it's used

Loratadine is used to relieve symptoms of seasonal allergy (seasonal allergic rhinitis) and other upper respiratory tract allergies. This medicine works by restricting the action of a natural chemical (called as, histamine) which acts on the body cell sites (H1 histamine receptor). Loratadine is also used to treat long-term hives.
Antihistamines
Loratadine belongs to a class of medicines called Antihistamines. Antihistamines help in relieving allergic symptoms. They do so by blocking the effects of histamines. Histamines are produced by the body and in-turn cause fever, itching, sneezing, a runny nose, or watery eyes in allergic conditions.

How to use

Follow directions on the product label, information guide, and provided by your doctor before using Loratadine. Consume this medicine as per your doctor's instructions.
Loratadine is consumed with or without food. Swallow the whole tablet of Loratadine with water.
The typical adult dose of Loratadine is 10 mg once daily or 2 teaspoonfuls (10 mg) of syrup once daily. The typical dose for children is 5 mg (1 teaspoonful) once daily. The maximum dose for adults of Loratadine is 10 mg per day. It takes 1 to 3 hours for this medicine to start its action.
Tell your doctor if your condition persists or worsens or if you develop new symptoms. Talk to your doctor if swelling of the face, swelling of lips, swelling of the tongue, swelling of the throat, difficulty in breathing due to narrowing of the airways, shock, rash, itching, and collapse. If you have any kidney disease, an initial dose of 10 mg every other day is recommended in patients having kidney disease with clearance rate less than 30 ml/min. In children of age 2 to 5 years with kidney disease, the initial dose should be 5 mg per day. If you have issues with the health of your liver, a low initial dose of 10 mg every other day is recommended in adults and children weighing more than 30 kg or 66.1 lb. In children weighing less than 30 kg or 66.1 lb, a dose of 5 ml (5 mg) is recommended.
If you are giving Loratadine to a child, be sure to use a product that is meant for use in children. Before giving this medicine, use the child's weight or age to find the right dose from the leaflet or product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.
If using the orally-disintegrating form of this medicine, make sure you do not consume any food or fluid 5 minutes before or after taking this medicine. Before taking the medicine out of the package, wash your hands thoroughly. Place the medicine on the tongue. Make sure you do not chew or swallow the medicine. You do not need to drink water after consuming the medicine. In certain cases, the medicine can taste slightly bitter. Also, ensure that you do not break or split the medicine.
If using the rapidly-dissolving tablet form of this medicine, chew this medicine or allow the medicine to dissolve on the tongue. Next, swallow the medicine with or without water.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Loratadine for symptoms for which it was not prescribed. Do not give Loratadine to others who may have similar symptoms as you. Self-medication can cause harm.
Store Loratadine at 2-30°C (36-86°F) for tablet, 2-25°C (36-77°F) for syrup and rapidly dissolving tablet, and 20-25°C (68-77°F) for suspension and capsule, and away from moisture. Keep this medicine away from children and pets.

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How to take Loratadine

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Loratadine depends on the following factors:
  • patient's age
  • patient's weight
  • patient's health
  • the health of the patient's liver
  • the health of the patient's kidneys

Loratadine Dosage

Dosage for symptoms of seasonal allergy (seasonal allergic rhinitis) and other upper respiratory tract allergies

Adult (adults)
  • Recommended: 10 mg (2 teaspoonfuls) once daily
  • Maximum: 10 mg (2 teaspoonfuls) daily
Children (aged 6 years and above)
  • Recommended: 10 mg (2 teaspoonfuls) once daily
  • Maximum: 10 mg (2 teaspoonfuls) daily
Children (aged 2 to 5 years)
  • Recommended: 5 mg (1 teaspoonful) once daily
  • Maximum: 5 mg (1 teaspoonful) daily
Children (aged 2-12 years and weighing more than 30 kg or 66.1 lb)
  • Recommended: 10 mg once daily

Dosage for long-term hives

Adult (adults)
  • Recommended: 10 mg (2 teaspoonfuls) once daily
  • Maximum: 10 mg (2 teaspoonfuls) daily
Children (aged 6 years and above)
  • Recommended: 10 mg (2 teaspoonfuls) once daily
  • Maximum: 10 mg (2 teaspoonfuls) daily
Children (aged 2 to 5 years)
  • Recommended: 5 mg (1 teaspoonful) once daily
  • Maximum: 5 mg (1 teaspoonful) daily
Children (aged 2-12 years and weighing more than 30 kg or 66.1 lb)
  • Recommended: 10 mg once daily

Minimum Age

2 year

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 10 mg
Syrup
Strength: 1 mg/ml
Tablet, orally disintegrating
Strength: 5 mg and 10 mg
Oral suspension
Strength: 5 mg/5 ml
Capsule
Strength: 10 mg
Tablet, chewable
Strength: 5 mg
Oral solution
Strength: 5 mg/5 ml

Special Instructions

Patients with liver disease
A low initial dose of 10 mg every other day is recommended in adults and children weighing more than 30 kg (66.1 lb). In children weighing less than 30 kg (66.1 lb), a dose of 5 ml (5 mg) is recommended.
Patients with kidney disease
An initial dose of 10 mg every other day is recommended in patients having kidney disease with clearance rate less than 30 ml/min.
Rapidly disintegrating tablets
The Loratadine rapidly disintegrating tablets can be taken with or without water. These tablets should be placed at the tongue. The disintegration of Loratadine occurs immediately.

Missed Dose

If a dose of Loratadine is missed, take it as soon as you remember. Skip the dose, if its almost time for next dose. Do not take a double dose to make up for the missed one.

Overdose

What to do if you overdose on Loratadine?
The treatment for overdose symptoms and supportive measures should be provided as required. Vomiting (emesis) should be induced in patients except in those with altered consciousness. Then, a slurry of charcoal (a carbon, used to absorb poisonous substances from the body) with water should also be given. In case, vomiting is unsuccessful or not recommended, stomach emptying (gastric lavage) can be done using normal saline. The use of saline cathartics may help in rapid passage of bowel content. After this, careful monitoring of the patient is recommended.
Symptoms of an overdose of Loratadine
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
  • drowsiness
  • headache
  • increased heartbeat
  • involuntary or uncontrolled movements (extrapyramidal signs)
  • palpitation
If you think you have overdosed on Loratadine, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Loratadine

Before you use Loratadine, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
Before you use Loratadine, tell your doctor of your medical history including liver disease, or kidney disease.
Loratadine should be used only when required in patients who are pregnant or planning to become pregnant. There are no adequate and well-controlled studies of Loratadine has been performed in pregnant women. Loratadine should be used while breastfeeding only when required. Loratadine may pass into the breast milk. A choice should be made whether to discontinue the breastfeeding or to discontinue using this medicine; this decision depends on the importance of the Loratadine to the mother. Consult with your doctor on the use of Loratadine, if you are trying to conceive.
Loratadine can make you feel sleepy. Be careful, especially while driving, while using heavy machinery, or when doing any activity that needs you to be completely alert. The consumption of alcohol with Loratadine can worsen the sleepiness. Loratadine may cause seizures in some people. Hence, you should discuss with your doctor before performing any activities where a loss of consciousness may cause harm to you or others.
This medicine may increase your sensitivity to sunlight and make you prone to sunburn. If this happens, limit your time outdoors to prevent sunburn. Use a sunscreen and cover your skin when you are outdoors. If you get sunburns on your body, consult with your doctor.

What precautions should be taken during Pregnancy and Nursing, and administering Loratadine to Children or the Older Adults?

Pregnant Women

Only When Necessary
Warning: There are no adequate and well-controlled studies of Loratadine has been performed in pregnant women.

Breastfeeding

Precaution
Warning: Loratadine may pass into the breast milk.

Younger Adults Population

Possibly safe
Warning: The safety and effectiveness of Loratadine in the children under two years have not been confirmed. This medicine can be used in children older than two years or it cannot be used in children with body weight less than 30 kg (66.1 lb).

Loratadine Side-effects

The following side-effects may commonly occur in children when using Loratadine. Discuss with your doctor if any of these side-effects last for a long time or are severe:
Rarely, the use of Loratadine may cause the following side-effects:
The following severe side-effects may also occur when using Loratadine:
  • heart diseases such as fast or irregular heartbeat
    If this happens, consult with your doctor.
  • liver diseases (such as abnormal liver function, jaundice, liver injury and inflammation of the liver)
    If such side-effect occurs, consult with your doctor.
  • If this happens, consult with your doctor.
  • severe allergic reaction (anaphylaxis and erythema multiforme)
    Symptoms: swelling of the lips, swelling of the face, swelling of the tongue, swelling of the throat, difficulty breathing due to narrowing of airways, shock, collapse, rash itching
    If this happens, stop taking this medicine and contact your doctor immediately.
  • Consult with the doctor if such side-effects occur.
  • abnormally heavy menstrual bleeding
    If this happens, consult with your doctor.
  • inflammation of the vagina (vaginitis)
    If such side-effect occurs, consult with your doctor.
Your doctor has prescribed this Loratadine because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Loratadine.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Loratadine by Severity and Frequency

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Side-effects in Children

Following are the side-effects of this medicine in young patients:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
  • collapse
  • difficulty breathing due to narrowing of airways
  • itching
  • rash
  • shock
  • swelling of the face
  • swelling of the lips
  • swelling of the throat
  • swelling of the tongue
If these symptoms occur then stop taking Loratadine and contact your doctor immediately.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Liver disease

Patients with liver disease are at an increased risk when using this medicine. Consult your doctor if you have a liver disease. Your doctor may change the dose according to your need.

Kidney disease

Patients with kidney disease are at an increased risk when using this medicine. Consult your doctor if you have a kidney disease. Your doctor may change the dose according to your need.

Drowsiness

Patients using more than the directed dose of Loratadine are at an increased risk. These patients may develop drowsiness. Do not take more than the recommended dose.

Allergy to Loratadine

Patients who are allergic to Loratadine are at an increased risk when using this medicine. In such patients, an allergic reaction may develop. If this happens, stop using this medicine and seek medical help immediately.

Family history

Patients with rare genetic problems such as Lapp lactase deficiency, galactose intolerance, and decreased absorption of glucose-galactose are at an increased risk when using this medicinal product that contains lactose. These patients should not take Loratadine.

Skin tests

Patients undergoing skin tests are at an increased risk when using this medicine. This medicine may prevent or reduce the positive results of skin reactivity index which results in wrong results of skin tests. This medicine should be stopped at least 48 hours before undergoing skin tests.

Pregnancy or breastfeeding

Patients who are pregnant or breastfeeding are at an increased risk when using this medicine. These patients should consult with a doctor before using Loratadine.

Interactions with Loratadine

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Loratadine may interact with cytochrome P450 3A4 (CYP3A4) inhibitors. When Loratadine is used with CYP3A4 inhibitors, the amount of Loratadine increases in the body and results in more chances of adverse events.
There may be an interaction of Loratadine with cytochrome P450 2D6 (CYP2D6) inhibitors. When Loratadine is used with CYP2D6 inhibitors, it results in an increased amount of Loratadine and adverse events of Loratadine.
Loratadine interacts with erythromycin, which is used to treat bacterial infection. When Loratadine is used with erythromycin, the amount of Loratadine increases in the blood and the amount of erythromycin decreases in the blood.
Special instructions need to be followed while taking this medicine along with cimetidine, which is used to treat heartburn and stomach ulcers. The use of Loratadine with cimetidine may increase the amount of Loratadine in the blood.
Your doctor's guidelines may need to be followed while taking this medicine along with ketoconazole, which is used to treat fungal infection. The amount of Loratadine in the blood may increases when taken with ketoconazole.
This page does not contain all the possible interactions of Loratadine. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Interactions of Loratadine by Severity

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Loratadine be not used?

Allergy

This medicine should not be used in patients with known allergic reaction to it. These patients are at an increased risk of severe allergic reaction. These patients may have the following symptoms if they use this medicine:
  • severe itching
  • red or purple coloured spots on the skin
  • hives
  • rash
  • photosensitivity reaction
  • swelling due to the fluid accumulation
  • severe allergic reaction (anaphylaxis)

Children under the age of two years

The safety and effectiveness of Loratadine in children under the age of two years have not been confirmed. So, this medicine should not be used in these patients.

Expired Medication

Taking a single dose of expired Loratadine is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Loratadine .
Allergy
Allergic Rhinitis
Hives
Loratadine - 1 learning sets

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