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Why it's used

Losartan is a prescription medicine that is used to treat high blood pressure. This medicine works by preventing the activity of certain natural substances that tighten the blood vessels. This medicine helps by making blood flowing smoothly and the heart to pump more effectively. Losartan is also used to reduce the risk of stroke in high blood pressure patients with an enlarged heart, and to treat kidney damage due to diabetes.
Losartan may also be used along with other medicines in the treatment of certain conditions as recommended by the doctor. It is used with Hydrochlorothiazide to reduce the risk of stroke in high blood pressure patients with an enlarged heart.
Angiotensin 2 Receptor Blocker
Losartan belongs to the Angiotensin 2 Receptor Blocker class of medicines. Angiotensin II receptor blockers are used for the treatment of high blood pressure and heart failure. These medicines act by relaxing the blood vessels and makes it easier for your heart to pump blood.

How to use

Follow directions on the product label, information guide, and provided by your doctor before using Losartan. Consume this medicine as per your doctor's instructions.
You should track your blood pressure levels regularly. Discuss your results with the doctor, especially if your blood pressure measurements are too high or too low. Your treatment may need changes.
Losartan is consumed with or without food. If a child is unable to swallow a tablet, a liquid form (suspension) is given after consultation with the pharmacist or doctor.
The typical adult dose of Losartan is 50 mg once daily as usual starting dose which can be increased to 100 mg according to the patient's blood pressure response to the medicine. The typical dose for children is 0.7 mg/kg or 0.3 mg/lb once daily (up to 50 mg). The maximum dose for adults of Losartan is 100 mg once daily per day. Losartan is typically used at the same time every day. There are no known habit-forming tendencies with this medicine.
Losartan is to be used for longer periods of time. Use of Losartan may be prescribed for the long-term to control the high blood pressure conditions. You should continue to use this medicine as directed by the doctor even if you feel well.
Tell your doctor if your condition persists or worsens or if you develop new symptoms. Talk to your doctor if swelling of the face, swelling of the lips, swelling of the throat, swelling of the tongue, low blood pressure, weight gain, swelling in feet, swelling in the hands, and swelling in the ankles. If you have issues with the health of your liver, The starting dose of 25 mg once daily is recommended in patients with abnormal liver function. Consult with your doctor before stopping the use of Losartan.
To see the impact of Losartan on the body, your doctor may recommend a lower initial dose. Please follow your doctor's instructions carefully.
If you are giving Losartan to a child, be sure to use a product that is meant for use in children. Before giving this medicine, use the child's weight or age to find the right dose from the leaflet or product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Losartan for symptoms for which it was not prescribed. Do not give Losartan to others who may have similar symptoms as you. Self-medication can cause harm.
Store Losartan at 15°C to 30°C (59°F to 86°F), away from moisture, and away from light. Keep this medicine away from children and pets.

How to take Losartan

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Losartan depends on the following factors:
  • patient's age
  • patient's weight
  • patient's health
  • the health of the patient's kidneys
  • medicines recommended by your doctor
  • any other medicines in use
  • herbal supplements consumed
  • response to treatment

Losartan Dosage

Dosage for high blood pressure

Adult
  • Recommended: 50-100 mg once daily as per patient's response to medicine
  • Initial: 50 mg once daily
  • Maximum: 100 mg once daily in morning
Children (children more than 6 years)
  • Initial: 0.7 mg/kg (0.3 mg/lb) once daily
  • Maximum: 50 mg once daily
Children (children (weight greater than 20 kg or 44.1 lb and less than 50 kg or 110.2 lb))
  • Recommended: 25 mg once daily
  • Maximum: 50 mg once daily
Children (children (weight more than 50 kg or 110.2 lb))
  • Recommended: 50 mg once daily
  • Maximum: 100 mg once daily

Dosage for high blood pressure conditions in patients with enlarged heart

Adult
  • Recommended: 50-100 mg once daily depending upon the patient's response to medicine
  • Initial: 50 mg once daily
  • Maximum: 100 mg once daily

Dosage for diabetic patients with high blood pressure and presence of protein in urine

Adult
  • Recommended: 50-100 mg once daily based on the patient's blood pressure conditions
  • Initial: 50 mg once daily
  • Maximum: 100 mg once daily

Dosage for diabetic patients with kidney disease

Adult
  • Recommended: 50-100 mg once daily based on the patient's blood pressure conditions
  • Initial: 50 mg once daily
  • Maximum: 100 mg once daily

Dosage for patients with loss of blood volume

Adult
  • Initial: 25 mg once daily

Minimum Age

6 years

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 25 mg, 50 mg, and 100 mg
Suspension
Strength: 2.5 mg/mL
Tablet, film coated
Strength: 25 mg, 50 mg, and 100 mg

Missed Dose

Take the missed dose as soon as you remember. Do not take a second dose to make up for the dose that you may have missed. Just continue with the next dose.

Overdose

What to do if you overdose on Losartan?
If you have taken more than the recommended dose of Losartan and symptoms like low blood pressure occur, treat the symptoms and provide supportive measures. The toxic effect can be reduced by taking activated charcoal. Activated Charcoal is a form of carbon that has small, low-volume pores. These pores help trap chemicals as in the case of poisoning.
Symptoms of an overdose of Losartan
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Losartan, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Losartan

Before you use Losartan, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
Before you use Losartan, tell your doctor of your medical and health history including the following: severe conditions of vomiting, severe diarrhea, liver problems, kidney problems, heart failure, or diabetes.
The use of this medicine may change red blood cells count (hemoglobin) and the ratio of the volume of red blood cells to the total volume of blood (hematocrit). A small decrease in hemoglobin and hematocrit value has been reported in patients while using this medicine.
The use of this medicine may change blood urea nitrogen. A minor increase in blood urea nitrogen level has been seen in patients while using this medicine.
The use of Losartan may change electrolyte level.
The use of this medicine may change blood pressure.
The use of Losartan may change blood creatinine levels. A minor increase in blood creatinine level has been reported in patients while using this medicine.
Losartan can make you feel sleepy. Be careful when using any machinery, driving a vehicle, or doing any other activity that needs you to be fully alert. The consumption of alcohol with Losartan can worsen the sleepiness.
The use of Losartan is known to be not safe for use in pregnant women. If you are planning to become pregnant or are currently pregnant, you should discuss with your doctor the potential impact of this medicine on the baby before you start to using it. The use of this medicine in pregnant women can cause injury to the developing fetus and is possibly fatal to the unborn baby. The use of Losartan is not safe for use in women who are breastfeeding. If you are breastfeeding a baby, discuss with your doctor if you should either discontinue breastfeeding or stop using this medicine while breastfeeding. It is unknown that if this medicine may pass into breast milk or not. Consult with your doctor on the use of Losartan, if you are trying to conceive.
This medicine may increase your sensitivity to sunlight. If this happens, use a sunscreen and cover your skin when you are outdoors. Limit your time in the sun. If you get a sunburn on your skin, consult with your doctor.

Losartan Side-effects

The following side-effects may commonly occur when using Losartan. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use of Losartan may cause the following side-effects:
The following severe side-effects may also occur when using Losartan:
  • liver disorders
    Symptoms: inflammation of the liver and inflammation of the pancreas
  • metabolic and nutrition disorders
    Symptoms: low sodium level in the blood
  • Symptoms: depression
  • Symptoms: low levels of thrombocytes
  • immune system disorders
    Symptoms: life-threatening allergic reaction (anaphylaxis), swelling of the lower layer of skin and inflammation of the blood vessels (vasculitis)
  • skin disorders
    Symptoms: increased sensitivity to light
  • heart disorders
  • stomach and intestinal disorders
    Symptoms: constipation
Your doctor has prescribed this Losartan because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Losartan.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Women during second and third trimester of pregnancy

Pregnant women are at an increased risk when using this medicine. Use of Losartan may cause side effects to an unborn baby which includes an incomplete development of the skull, failure of the kidneys to produce urine, low blood pressure, kidney failure, and can be possibly fatal. Discontinue the use of Losartan as soon as pregnancy is detected.

Patients with decreased blood volume and salt level

Such patients may have a decrease in blood pressure while using Losartan. A low dose is recommended before starting the therapy with Losartan.

Worsening of the functioning of kidneys

Patients using Losartan are at an increased risk of kidney failure due to obstruction in the activity of the renin-angiotensin system and diuretics which helps to control the high blood pressure conditions. Consider proper monitoring or discontinuation of the therapy in patients who develop a decrease in the functioning of kidneys while using Losartan.

Increased potassium levels in the blood (hyperkalemia)

Hyperkalemic patients are at an increased when using this medicine. Proper monitoring of potassium levels in the blood is achieved by discontinuation or lowering the dose of Losartan in such patients.

Abnormal functioning of the liver

Such patients may have increased levels of Losartan in the blood. A low dose of Losartan should be given to patients with a history of abnormal liver functioning.

Patients with heart and brain diseases

These patients may have an increased risk of heart attack or stroke.

Heart failure

Patients with heart failure are at an increased risk when using this medicine. These patients may have an increased risk of severe low blood pressure and abnormal functioning of the kidney. Take necessary precautions while using this medicine in these patients.

Patients using blood pressure lowering agents (angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers or aliskiren) in combination

Such patients may have an increased risk of high potassium levels in blood, low blood pressure and kidney failure. The combined therapy of these agents with Losartan is not recommended as it may lead to blockage of the renin-angiotensin-aldosterone system.

Electrolyte imbalance

Patients with abnormal functioning of the kidney with or without diabetes are at an increased risk when using this medicine. Such patients may have an increased risk of high potassium levels in the blood in diabetic patients with kidney disease. Careful monitoring of potassium levels in the blood and kidney parameter (creatinine clearance value) is required in patients with heart failure.

Patients with narrowing of large blood vessels of heart or abnormally thickened heart muscles

Losartan should be taken with caution in such patients.

Patients with increased hormonal levels (aldosterone)

Such patients are at an increased risk when using this medicine. Such patients will not respond adequately to blood pressure lowering effects. Use of Losartan is not recommended in these patients.

Interactions with Losartan

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Losartan interacts with nonsteroidal anti-inflammatory drugs, which are used to reduce pain, fever, and inflammation. The patients using Losartan and non-steroidal anti-inflammatory drugs may see an increased risk of worsening of functioning of kidney, kidney failure, increased potassium levels in the blood, and blood pressure lowering effects. The functioning of the kidney should be monitored periodically in patients receiving Losartan and NSAID therapy.
There may be an interaction of Losartan with lithium, which is used to treat depression. The combined use of Losartan with lithium may lead to harmful effects and increased levels of lithium in blood. The blood lithium level should be monitored when both the medicines used in combination.
Losartan may interact with drugs which increase blood potassium level. The use of Losartan with these drugs (for example potassium-sparing diuretics, amiloride, triamterene, spironolactone, heparin, potassium supplements or salt substitutes) may raise the levels of potassium in the blood. The combined use of Losartan with these drugs is not recommended. Proper monitoring of potassium levels in the blood is required.
Your doctor's guidelines may need to be followed while taking this medicine along with other renin-angiotensin system (RAS) inhibitors, which are used to treat high blood pressure. The use of Losartan with other renin-angiotensin system inhibitors (angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, lisinopril or aliskiren) may lead to an increased risk of low blood pressure, fainting, increased potassium level in the blood, and acute kidney failure. Avoid the combined use of Losartan with another renin-angiotensin system (RAS) inhibitors in patients with abnormal functioning of the kidneys.
Special instructions need to be followed while taking this medicine along with cytochrome P450 2C9 enzyme inhibitors (for example, rifampicin) which are used to treat bacterial infections. The combined use of Losartan with rifampicin may lead to decreased levels of an active metabolite of Losartan in the blood.
There may be an interaction of Losartan with potassium sparing diuretics (amiloride, triamterene, spironolactone) and heparin, which are used to treat high blood pressure and prevents blood clotting. Use of Losartan with potassium-sparing diuretics may increase the level of potassium in the blood. The combined use of both the medicines is not recommended.
Losartan may interact with other antihypertensive agents, anti-depressants, anti-psychotics, central nervous system depressants and anti-cancer drugs (tricyclic antidepressants, baclofene and amifostine) which are used to treat high blood pressure, depression, anxiety, muscle spasms and cancer. When Losartan is used with other antihypertensive agents may increase the risk of low blood pressure.
This page does not contain all the possible interactions of Losartan. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Losartan is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.

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