When two or more medicines
are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction
interacts with multidrug and toxin extrusion inhibitors (ranolazine
, and cimetidine
), which are used to treat chest pain
, bacterial, viral, and fungal infections. Use of Metformin with multidrug and toxin extrusion inhibitors (MATE), increases the level of Metformin in the body. It may also increase the risk of lactate
buildup in the body. Dose adjustment is needed while using these medicines in combination.
may interact with furosemide
, which is used to treat fluid build-up in patients with heart failure or kidney disease and conditions of high blood pressure. Use of furosemide
increases the level of Metformin in the blood. Proper monitoring of the functioning of the kidney and blood glucose
levels test is required to adjust the dose of Metformin.
Special instructions need to be followed while taking this medicine along with thiazides, diuretics
, sympathomimetics, and calcium channel blockers, which are used to treat blood pressure. When Metformin
is used with thiazides, diuretics
, sympathomimetics or calcium
channel blockers, may lead to loss of blood glucose
control. These patients should be observed closely for low blood sugar
Your doctor's guidelines may need to be followed while taking this medicine along with inducers of organic cationic transporter-1 (rifampicin
), which are used to treat bacterial infections. When Metformin
is used with organic cation transporter-1 inducer, may increases the absorption in stomach and intestine and alters the effectiveness of Metformin. Appropriate adjustment of dosage is required while taking both drugs.
Special instructions need to be followed while taking this medicine along with inhibitors of organic cationic transporter-1 and organic cationic transporter- 2 (crizotinib
), which are used to treat cancer
. When Metformin
is used with crizotinib, olaparib may alter the effectiveness and removal of Metformin from the kidney. Appropriate adjustment of dosage is required while taking both drugs.
interacts with nonsteroidal anti-inflammatory drugs including selective cyclooxygenase-2 inhibitors, angiotensin II receptor blockers, and angiotensin-converting enzyme
inhibitors which are used to treat pain
, inflammation and high blood pressure. Use of Metformin with these drugs may affect the functioning of the kidney which further leads to the risk of lactate
build-up in the body. Close
monitoring of the functioning of the kidney is required when using these drugs with Metformin.
There may be an interaction of Metformin
with iodinated contrast agents, which are used during X-ray
procedure. Use of iodinated contrast agents which are given through the blood vessels may increase the risk of acid build up inside the body and decrease the functioning of the kidney. Do not take this medicine in patients with abnormal functioning of the liver
or kidney, alcoholism or heart failure and in the patients who are taking iodinated contrast through arteries. Discontinue the use of Metformin
before or at the time of treatment with iodinated contrast agents.
This page does not contain all the possible interactions of Metformin. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines
without the approval of your doctor.