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Why it's used

Nimesulide is used to treat acute (short-term) pain, painful osteoarthritis (swelling in the joints) and pain related with menstrual periods (primary dysmenorrhoea). This medicine works by blocking the enzyme activity (cyclooxygenase 1 and cyclooxygenase 2) which generates pain signals in the body. This medicine helps by exerting pain killing actions.
Nonsteroidal Anti-inflammatory Drugs
Nimesulide is a prescription medicine that belongs to a class of medicines called Nonsteroidal Anti-inflammatory Drugs. Nonsteroidal anti-inflammatory drugs, also called as NSAIDs, help reduce fever, decrease pain, and prevent clotting of blood. NSAIDs also reduce inflammation in the body when used in higher doses.

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How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Nimesulide. If you have any questions related to this medicine, ask your doctor or pharmacist. Consume this medicine as recommended by your doctor.
Nimesulide is consumed after food.

Typical Dosage

The typical dose of Nimesulide is 100 mg twice a day after meals. The usual dose for children is 100 mg twice a day. The maximum adult dose of Nimesulide is 100 mg twice daily in a day. This medicine is typically used for a period of 15 days for acute pain, 15 days for painful swelling in the joints (painful osteoarthritis), and 15 days for pain related with menstrual periods (primary dysmenorrhoea). This medicine is not known to be habit-forming.
This medicine should be used on an as-needed basis.

Talk to Your Doctor

Talk to your doctor if you develop new or worsening symptoms. Tell your doctor if the loss of appetite, nausea, vomiting, stomach pain, persistent tiredness, dark urine, fever, flu-like symptoms, feeling achy, feeling unwell, and chills. If you have issues with the health of your liver, The use of Nimesulide 100mg Tablets/granules is not recommended in patients with liver dysfunction.
Your doctor may recommend a lower initial dose of this medicine to see the impact of this medicine on the body. Please follow your doctor's directions. Older patients may see an increase in the incidence of side-effects with this medicine. As a result, a lower dose may be recommended for older patients.

Use in Children

The safety and effectiveness of using Nimesulide in children has not been established. The use of Nimesulide is not intended for children less than 12 years. However, patients of 12-18 years can take Nimesulide tablets/granules, and there is no need for dose adjustment in such patients.

Avoid Alcohol

Avoid the consumption of alcohol with Nimesulide.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Nimesulide for conditions for which it was not prescribed. Do not give Nimesulide to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

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How to take Nimesulide

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Nimesulide depends on the following factors:
  • patient's health
  • the health of the patient's kidneys

Nimesulide Dosage

Dosage for acute pain and symptoms of osteoarthritis

Adult
  • Recommended: 100 mg twice daily after meals
Children (12-18 years)
  • Recommended: 100 mg twice daily after meals

Minimum Age

12 years

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 100 mg
Granules
Strength: 100 mg

Precautions while using Nimesulide

Before you use Nimesulide, tell your doctor of your medical and health history including the following:
  • alcohol addiction
  • allergic to Nimesulide
  • cerebrovascular bleeding
  • drug abuse
  • heart failure
  • increased liver enzymes
  • kidney disorders
  • liver diseases
  • long-term inflammatory bowel disease causing inflammation in the digestive tract (ulcerative colitis or Crohn’s disease)
  • severe blood clotting disorders
  • stomach and intestinal bleeding
  • stomach or intestinal ulcers
  • stroke
Before you use Nimesulide, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Discuss with your doctor if you are allergic to acetylsalicylic acid, or other non-steroidal anti-inflammatory drugs.

Use when Pregnant

Nimesulide is not safe for use in women who are pregnant. If you are pregnant or planning to become pregnant, you should discuss the impact on the fetus with your doctor before you start using this medicine. The use of Nimesulide should not be done during the last 3 months of pregnancy. Nimesulide belongs to the NSAID class of medicines. NSAIDs should not be taken after 29 weeks of pregnancy as these medicines may cause serious harm to the unborn baby.

If Breastfeeding

Nimesulide is not safe for use in women who are breastfeeding. If you are breastfeeding, discuss with your doctor if you should either discontinue breastfeeding, or stop using this medicine during this period. The use of Nimesulide is not recommended for women who are breastfeeding their infants.

If trying to Conceive

Consult with your doctor on the use of Nimesulide, if you are trying to conceive. Patients who are planning to conceive should inform their doctor since the use of Nimesulide may decrease fertility.

Alcohol

Increase in Risk

This medicine may cause stomach bleeding. Regular use of tobacco or alcohol may increase the risk. Discuss with your doctor if you smoke and drink alcohol regularly.

Side-effects in Older Patients

Older patients may have a higher incidence of side-effects when using Nimesulide. Elderly patients may see an increased risk of stomach and intestinal bleeding, liver damage, abnormal functioning of the kidneys, abnormalities of the heart, and ruptured bowel.

Nimesulide Side-effects

The following side-effects may commonly occur in older patients on the use of Nimesulide. Discuss with your doctor if any of these side-effects last for a long time or are severe:
  • abnormal functioning of the kidneys
  • abnormalities of the heart
  • liver damage
  • ruptured bowel
  • stomach and intestinal bleeding
The following severe side-effects may also occur when using Nimesulide:
  • Liver disorders
    Symptoms: liver damage
Your doctor has prescribed this medicine because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious cases of side-effects. This page does not contain a complete list of all possible side-effects.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Liver Damage

Patients with severe injuries of liver and abnormal liver function tests are at an increased risk. These patients may experience symptoms such as eating disorder, nausea, vomiting, stomach pain, fatigue, and dark colored urine. Rare chances of liver damage have been reported with the use of Nimesulide. Discontinue the use of Nimesulide in patients with severe injuries of liver and abnormal liver function tests.

Use of Other Analgesics

Patients are advised to avoid the use of other analgesics while undergoing treatment with Nimesulide.

History of Stomach and Intestinal Events

Patients with history of stomach and intestinal disorders are at an increased risk. Such patients may develop an increased risk of stomach and intestinal bleeding and ulceration in the stomach. Take necessary precautions while using Nimesulide in patients with stomach and intestinal disorders. Discontinue the use of Nimesulide in patients who are developing the severe condition of the stomach and intestinal bleeding.

Kidney or Heart Damage

Elderly patients are particularly more susceptible to the side effects of NSAIDs, including stomach and intestinal bleeding and perforation, damaged kidney, heart and liver function. The use of Nimesulide 100mg tablets or granules may result in a decline of the functioning of kidneys. Caution is needed in patients with kidney or heart damage. In the case of decline, the treatment should be discontinued. Proper clinical monitoring should be advised.

Bleeding Disorders

Nimesulide can interfere with platelet function. The patients who have the sensitivity to bleed (bleeding diathesis) should use Nimesulide with caution.

Damaged Female Fertility

The use of 100mg tablets or granules of Nimesulide may damage the fertility condition of women. Nimesulide is not advised in women trying to conceive. Women who are undergoing research of infertility, Nimesulide 100mg granules/ tablets should be withdrawn.

Interactions with Nimesulide

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Nimesulide. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Lithium

Nimesulide interacts with lithium, which is used for the treatment of mood disorders. The doctor or pharmacist should be informed that the patient is taking lithium before starting treatment with Nimesulide.

Diuretics

There may be an interaction of Nimesulide with diuretics, which are used to prevent some heart problems, high blood pressure, and some kidney problems. The doctor or pharmacist should be informed that the patient is taking diuretics before starting treatment with Nimesulide.

Anticoagulants

Nimesulide may interact with anticoagulants such as aspirin and other salicylates, which are used to prevent blood clotting. The doctor or pharmacist should be informed that the patient is taking anticoagulants before starting treatment with Nimesulide.

Cyclosporin

Your doctor's guidelines may need to be followed while taking this medicine along with cyclosporin, which is used as an immunosuppressant. The doctor or pharmacist should be informed that the patient is taking cyclosporins before starting treatment with Nimesulide.

Methotrexate

Special instructions need to be followed while taking this medicine along with methotrexate, which is used to treat cancer and joint pain. The doctor or pharmacist should be informed that the patient is taking methotrexate before starting treatment with Nimesulide.

Brands

Following are the top brand names of Nimesulide in countries around the world:

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Nimesulide is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Nimesulide .
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