When two or more medicines
are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction
may interact with antiretroviral drugs, which are used to treat viral infections like HIV/AIDS caused by a retrovirus (atazanavir
, and nelfinavir
). Proton pump inhibitors decrease the amount of atazanavir
and nelfinavir in the body which may result in reduced therapeutic effect of the antiretroviral medicines. Omeprazole
, when used in combination with saquinavir
, increases the level of saquinavir in the blood which further leads to an increase in harmful effects. The use of proton pump inhibitors with atazanavir and nelfinavir is not recommended. While in the case of saquinavir, a lower dose of saquinavir is required.
There may be an interaction of Omeprazole
with medicines whose
absorption depends on stomach pH (such as, ketoconazole
, iron salts
esters, and digoxin
). When using Omeprazole
with these medicines, it decreases the absorption of ketoconazole, ampicillin, iron salts
, esters, and erlotinib. Omeprazole
increases the absorption of digoxin
. Patients may need to monitor digoxin level in blood when taken in combination with Omeprazole
interacts with drugs that are metabolized in the liver
(such as, diazepam
, benzodiazepines, and phenytoin
can extend the duration of the removal of these medicines from the body. Use of this medicine with warfarin may result in increased blood clotting time which maybe possibly fatal. When using this medicine with warfarin, prothrombin time should be monitored.
Special instructions need to be followed while taking this medicine along with clopidogrel
, which is a medicines used to prevent blood clotting. The use of Omeprazole
with clopidogrel may result in reduced levels of clopidogrel in the body. Avoid the use of Omeprazole
and clopidogrel in combination.
Your doctor's guidelines may need to be followed while taking this medicine along with tacrolimus
, which is used to treat a skin condition called eczema
and lowers the risk during organ transmission from healthy donor to recipient. The use of Omeprazole
with tacrolimus results in an increase in the level of tacrolimus in blood. Careful monitoring of the functioning of kidneys and dose adjustment is required when both the drugs are used in combination.
may interact with methotrexate
, which is used to treat cancer
. The use of proton pump inhibitors with methotrexate may increase the level of methotrexate in blood. When a high dose of methotrexate is used, a temporary withdrawal of Omeprazole
There may be an interaction of Omeprazole
with St John’s Wort, a plant which is used to treat depression
. St John’s Wort decreases the amount of Omeprazole
(CYP2C19) metabolizers. Avoid the combined use of St. John’s Wort with this medicine.
interacts with voriconazole
, which is used to treat fungal infections. When using this medicine with voriconazole, it may results in increased levels of Omeprazole
in the blood by decreasing its rate of metabolism. Dose adjustment is required in patients with Zollinger-Ellison syndrome
Special instructions need to be followed while taking this medicine along with cilostazol
, which is used to prevent blood clotting. When both the drugs are used in combination, the levels of cilostazol
get increased. A dose reduction of cilostazol is required from 100 mg twice daily to 50 mg twice daily.
Your doctor's guidelines may need to be followed while taking this medicine along with rifampin
, which is used to treat tuberculosis
infection. Use of rifampin may lead to decrease in Omeprazole
level in the blood. The combined use of rifampin with this medicine should be avoided.
may interact with posaconazole
, which are used to treat fungal infections. The absorption rate and clinical effectiveness of these drugs is reduced when used in combination with Omeprazole
. The combined use of posaconazole with this medicine should be avoided.
This page does not contain all the possible interactions of Omeprazole. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines
without the approval of your doctor.