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Why it's used

Medcan Capsule is used to treat the fungal infection of the vagina (also called, vaginal candidiasis). This medicine works by preventing the formation of an enzyme (ergosterol) which is necessary for the synthesis of the fungal cell wall. Medcan Capsule is also used to treat fungal infection of mouth, throat, and pharynx, to treat brain and spinal cord infection (cryptococcal meningitis) in AIDS patients, to prevent fungal infection in patients undergoing bone marrow transplantation who receive radiation therapy and chemotherapy, to treat urinary tract infection, to treat inflammation of membrane that covers abdominal organs (peritonitis), to treat pneumonia, to treat fungal infection of the blood (candidemia), to treat fungal infection of internal body organs such as liver, kidney, brain, and heart (disseminated candidiasis), and to treat fungal inflammation of penis head (candidal balanitis).
Azole Antifungal
Medcan belongs to the Azole Antifungal class of medicines. Azole antifungals are a group of drugs that treat fungal infections of the skin and body, including athlete's foot, fungal nail infections, ringworm, and vaginal candidiasis. These medicines limit the growth of a wide range of fungi by damaging the fungal cell membrane.

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How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Medcan Capsule. If you have any questions related to this medicine, ask your doctor or pharmacist. Use this medicine as recommended by your doctor.
Medcan Capsule is used with or without food.

Typical Dosage

The typical dose of Medcan is 100-400 mg once a day (not more than 600 mg per day). The usual dose for children is 3-12 mg/kg (1.4-5.4 mg/lb) of body weight. The maximum adult dose of Medcan is 400 mg in a day. This medicine is typically used for a period of 2-3 weeks for fungal infection of mouth, throat, and pharynx, 10-12 weeks for brain and spinal cord infection in AIDS patients, and 7 days for fungal infection in patients undergoing bone marrow transplantation. This medicine is not known to be habit-forming.
This medicine should be used on an as-needed basis. This medicine can be given for 10-12 weeks in the initial treatment of brain and spinal cord infection (cryptococcal meningitis).
The injection form of the medicine may be used on the veins. Medcan injection is intended for use in the veins only. The intravenous infusion of Medcan is taken at the rate of approximately 200 mg/hour, which is given as a continuous infusion. Visually analyze for any impurity and discoloration of the solution prior to injecting into the veins.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.

Talk to Your Doctor

Talk to your doctor if you develop new symptoms. Tell your doctor if infection returns after seven days, more than two infections occur within 6 months, and no improvement in symptoms of infection after seven days of treatment. If you have any kidney disease, There is no need for adjustment of single dose for vaginal candidiasis in patients with kidney dysfunction, and the patients who are on multiple doses of Medcan, an initial dose of 50-400 mg is given. Further dosage adjustment depends upon the clinical condition.
Your doctor may recommend a lower initial dose of this medicine to see the impact of this medicine on the body. Please follow your doctor's directions. Older patients may see an increase in the incidence of side-effects with this medicine. As a result, a lower dose may be recommended for older patients.

Use in Children

If you are giving Medcan Capsule to a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child's weight or age to find the right dose from the product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Lab Tests

Your doctor may request that specific lab tests be performed before you start using Medcan Capsule. You may need to have Antibiotic Susceptibility test. The test is done to select appropriate therapy at appropriate doses for fungal infection.

Storage

You should store Medcan Capsule at 5°C-30°C (41°F-86°F), and away from moisture. Store the medicine away from the reach of children and pets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Medcan Capsule for conditions for which it was not prescribed. Do not give Medcan Capsule to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

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How to take Medcan

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Medcan depends on the following factors:
  • patient's age
  • patient's weight
  • patient's health
  • the health of the patient's liver
  • medicines recommended by your doctor
  • any other medicines in use
  • response to treatment

Medcan Dosage

Dosage for infection of the food pipe (esophageal candidiasis)

Adult
  • Recommended: 200 mg first day, followed by 100 mg once daily
  • Maximum: 400 mg/day for three weeks
Children
  • Recommended: 6 mg/kg (2.72 mg/lb) first day, followed by 3 mg/kg (1.36 mg/kg) of dose once daily
  • Maximum: 12 mg/kg/day (5.45 mg/lb/day) for a minimum of three weeks and for at least 2 weeks following the symptoms.

Dosage for fungal infection of mouth and throat

Adult
  • Recommended: 200 mg first day, followed by 100 mg dose once daily for not less than two weeks
Children (6 months to 13 years)
  • Recommended: 6 mg/kg (2.72 mg/lb) first day, followed by 3 mg/kg (1.36 mg/lb) dose once daily. Treatment should be given for not less than two weeks to decrease the likelihood of getting ill again

Dosage for fungal infection on skin or mucous membrane

Adult
  • Maximum: 400 mg daily
Children
  • Recommended: 6-12 mg/kg/day (2.72 - 5.45 mg/lb/day)

Dosage for urinary tract infections

Adult
  • Recommended: 50-200 mg of daily dose

Dosage for inflammation of the lining of the abdominal wall (peritonitis)

Adult
  • Recommended: 50-200 mg of daily dose

Dosage for infection of the brain and spinal cord

Adult
  • Recommended: 400 mg first day, followed by 200 mg of dose once daily for 10-12 weeks. Based on the medical judgment of the patient’s response to Medcan therapy, dose of 400 mg once daily may be used.
Children
  • Recommended: 12 mg/kg (5.45 mg/lb) first day, followed by 6 mg/kg (2.72 mg/lb) once daily for 10-12 weeks

Dosage for vaginal and vulval yeast infections

Adult
  • Recommended: 150 mg single oral dose

Dosage for patients undergoing bone marrow transplantation

Adult
  • Recommended: 400 mg once daily for 7 days. Patients who are expected to have severe decreased white blood cells (less than 500 neutrophils per cu mm) should start Medcan prophylaxis several days before the expected onset of decreased white blood cells (neutropenia), and continue the same for 7 days after the neutrophil sumup rises above 1000 cells/cu mm.

Dosage for suppression of relapse of meningitis

Adult
  • Recommended: 200 mg once daily
Children
  • Recommended: 6 mg/kg (2.72 mg/lb) once daily

Minimum Age

6 months

Maximum Age

65 years

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 50, 100, 150 and 200 mg
Oral suspension
Strength: 350 mg or 1400 mg
Injection
Strength: 200 mg/100 mL, 400 mg/200 mL
Capsule
Strength: 150 mg

Special Instructions

Oral suspension
Shake oral suspension well before use. Store the reconstituted suspension between 41°F - 86°F (5°C - 30°C). Discard the unused portion after 2 weeks. It is necessary to protect it from freezing.
Capsule
One capsule should be swallowed completely. A capsule is not recommended for children (under 16 years) and elderly patients over 60 years.
Injection
The intravenous infusion of Medcan should be given at a maximum rate of approximately 200 mg/hour, as a continuous infusion. Do not use the solution if it is precipitated or cloudy or if the seal is not intact.

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued.

Overdose

What to do if you overdose on Medcan?
If you have taken more than the recommended dose of Medcan get medical advice immediately. If necessary, the toxic effect can be reduced by cleaning out the contents of the stomach (gastric lavage). Removal of Medcan may be increased by excessive urine formation (forced diuresis) and removing waste products from the blood (hemodialysis).
Symptoms of an overdose of Medcan
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
  • hallucination
  • suspiciousness and mistrust of others (paranoid behavior)
If you think you have overdosed on Medcan Capsule, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Medcan

Before you use Medcan, tell your doctor of your medical and health history including the following:
  • existing irregular heartbeat (proarrhythmic disease)
  • kidney dysfunction
Before you use Medcan Capsule, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic any of the following substances: other azoles.
The use of this medicine may change transaminases and alkaline phosphatase. This medicine should be used with caution in patients with abnormal liver function. Careful monitoring of liver enzymes is required in such patients.

Seizures

Medcan Capsule can make you feel sleepy. Be careful when using any machinery, driving a vehicle, or doing any other activity that needs you to be fully alert. The consumption of alcohol with Medcan Capsule can worsen the sleepiness. Medcan Capsule may cause rarely seizures in some people. If you perform any activities where a loss of consciousness may cause harm to you (or others), you should discuss with your doctor.

Use in Pregnancy

Consult with your doctor on the use of Medcan during pregnancy, or if you are planning to become pregnant. Using high doses of Medcan in women during their first 3 months of pregnancy can cause birth defects among infants. The features seen in the infants were: flat head syndrome (brachycephaly), abnormal facies, abnormal skull development, splits in the roof of the mouth (cleft palate), bow-leggedness (femoral bowing), thin ribs and long bones, birth defect of shortened joint (arthrogryposis), and birth defect of structure of the heart (congenital heart disease).

Use while Breastfeeding

The use of Medcan Capsule Medcan Capsule while breastfeeding should only be when required. Cautions should be taken while breastfeeding as this medicine passes into breast milk.

Use while Conceiving

Consult with your doctor on the use of Medcan, if you are trying to conceive. The patient should be informed about the harmful effects on the unborn baby.

Side-effects in Older Patients

Medcan Capsule may cause increased incidence of side-effects in older patients. Elderly patients may see an increased risk of the reduced functioning of the kidney.

Side-effects in Children

Medcan may cause an increased risk of side-effects in children. Children using this medicine may see an increased risk of vomiting, abdominal pain, nausea, diarrhea, increased levels of transaminases, and increased levels of alkaline phosphatase.

Medcan Side-effects

The following side-effects may commonly occur when using Medcan Capsule. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in older patients on the use of Medcan Capsule. Discuss with your doctor if any of these side-effects last for a long time or are severe:
The following side-effects may commonly occur in children when using Medcan Capsule. Discuss with your doctor if any of these side-effects last for a long time or are severe:
Rarely, the use of Medcan Capsule may cause the following side-effects:
The following severe side-effects may also occur when using Medcan Capsule:
  • liver disorders (possibly fatal)
    Symptoms: inflammation of the liver (hepatitis), reduced bile flow from the liver (cholestasis) severe liver failure
    Patients should be monitored for the development of more severe liver injury. Medcan should be discontinued if clinical signs and symptoms are constant with liver disease.
  • heart disorder such as heart rhythm disorder (QT prolongation and torsade de pointes) (sudden heart death)
    Medcan should be taken with caution by patients with structural heart disease, electrolyte abnormalities or proarrhythmic conditions.
  • central nervous system
    Symptoms: seizures
  • hematopoietic and lymphatic disorders
    Symptoms: decreased white blood cells (leukopenia), abnormally low amount of white blood cell (neutropenia), deficiency of granulocytes in the blood, low level of thrombocytes decreased amount of red blood cells (anemia)
  • Symptoms: high cholesterol (hypercholesterolemia), high level of triglycerides in the blood (hypertriglyceridemia) low potassium level
  • gastrointestinal disorder
    Symptoms: reduced bile flow from the liver (cholestasis), liver damage, dry mouth, vomiting indigestion
  • nervous system disorder
    Symptoms: drowsiness
  • skin and appendages disorders
    Symptoms: severe drug-related disorder (acute generalized exanthematous-pustulosis), severe skin disorder (Stevens-Johnson syndrome), severe skin reaction redness and peeling of the skin (dermatitis exfoliative)
Your doctor has prescribed this medicine because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious cases of side-effects. This page does not contain a complete list of all possible side-effects.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Liver Injury

Patients with abnormal liver function are at an increased risk when using this medicine. These patients may have a fatal liver damage. Monitoring should be required for the development of more severe liver injuries. This medicine should be discontinued if the signs and symptoms consistently develop with the use of Medcan.

Severe Allergic Reaction (Anaphylaxis)

The patients with anaphylaxis are at an increased risk when using this medicine. This medicine should be discontinued if the patient experiences a severe allergic reaction.

Skin Disorder

Patients with serious disorders such as AIDS and cancer are at an increased risk. These patients may develop serious skin rashes when using this medicine. Closely monitor the patients who develop rashes and the medicine should be discontinued in case of symptoms further progress.

Women in their first Trimester of Pregnancy

The use of this medicine in a high dose in women who are in their first trimester are at an increased risk of having birth defects in their baby. The children from these women may have short head (brachycephaly), abnormal facies, abnormal skull development, splits in the upper lip and the roof of the mouth (cleft palate), bent leg bone (femoral bowing), thin ribs and long bones, curving of joints (arthrogryposis), and heart disease related to birth. The pregnant women should be informed of the potential hazard to the child.

Abnormal Functioning of Kidney Glands

Patients on treatment with Medcan may experience adrenal insufficiency.

Heart Problems

Patients with low potassium level and heart failure are at an increased risk when using this medicine. Such patients are at risk of life-threatening heart disorders causing rhythm problems of the heart. Medcan should be taken with caution in patients of heart rhythm disorders.

Kidney Dysfunction

Patients with a disturbance in the functioning of the kidney are at an increased risk. Medcan should be given with caution to patients who have kidney problems.

Use of Halofantrine

Patients taking Medcan with halofantrine are at an increased risk. Such patients may experience prolonged and irregular heartbeat. Medcan and halofantrine should not be used together.

Use of Terfenadine

Patients taking Medcan with terfenadine are at an increased risk. Such patients may experience abnormal heart rhythm disorder (QT prolongation). The use of Medcan at a dose lower than 400 mg per day with terfenadine should be monitored carefully.

Use of Cytochrome P450 Enzymes

Patients taking Medcan with other compounds metabolized by CYP2C9 and CYP3A4 enzymes are at an increased risk. Patients should be carefully monitored and caution should be exercised when using these combinations.

Intolerance to Sugars

Patients with a family history of galactose intolerance and defect in glucose-galactose absorption are at an increased risk. Such patients should not be advised to take Medcan capsules containing lactose.

Interactions with Medcan

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Medcan Capsule. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Gastroprokinetic Agent

Your doctor's guidelines may need to be followed while taking this medicine along with cisapride, which is used to increase gastric motility. When Medcan is used with cisapride, there has been a significant increase in cisapride blood levels and abnormal heartbeat (prolongation of QTc interval). Use of both the medicines together is not recommended.

Anticonvulsants

Medcan Capsule interacts with phenytoin, which is used to treat epilepsy. When Medcan is used with this medicine, it increases the level of phenytoin in the blood. Such patients should be monitored carefully for elevated phenytoin levels.

Anticoagulants

There may be an interaction of Medcan with anticoagulants, which are used to prevent blood clot formation. When Medcan is used with anticoagulants such as coumarin and warfarin, it can cause bleeding problems such as skin injury that results in a discoloration of the skin (bruising), bleeding from nasal cavity (epistaxis), stomach and intestinal bleeding, presence of blood in urine (hematuria), and black tarry stools (melena). These bleeding problems have been reported in along with increasing the blood clotting time in such patients. In such patients, time taken by blood to clot (prothrombin time) should be monitored carefully.

Oral Hypoglycemics

Medcan Capsule may interact with oral hypoglycemics (tolbutamide, glyburide, and glipizide), which are used to lower the blood glucose levels. This medicine decreases the metabolism of oral hypoglycemic medicines and increases their level in the blood. When Medcan is used with these medicines, carefully monitoring of blood glucose levels is required. The dose of these medicines should also be adjusted in such patients.

Antihistamines

Special instructions need to be followed while taking this medicine along with antihistamines (terfenadine and astemizole), which are used to relieve allergy symptoms. The patients using these medicines may develop abnormal and prolonged heartbeat. Also, when the combination of these drugs is used at higher doses involving Medcan 400mg or 800 mg, Medcan significantly increases the blood levels of terfenadine. Similarly, use of Medcan with astemizole has resulted in decreased clearance of astemizole. Use of Medcan and astemizole is not recommended and use of Medcan with terbinafine at doses lower than 400 mg/day should be monitored carefully.
Your doctor's guidelines may need to be followed while taking this medicine along with Erythromycin. When Medcan is used with erythromycin, it may increase the risk of abnormal and prolonged heartbeat that may cause heart muscles damage. Avoid using these medicines together.

Opioids Analgesics

Medcan Capsule interacts with opioid analgesics (fentanyl and alfentanil), which are used to relieve pain. When Medcan is used with these medicines, it may lead to failure of the lungs to exchange carbon dioxide and oxygen. Due to the possibility of fatal outcomes, avoid using these medicines together. Patients should be monitored closely for the risk of respiratory-depression. Dosage adjustment of alfentanil and fentanyl may be necessary.

Antimalarial Drugs

Special instructions need to be followed while taking this medicine along with antimalarial drugs (halofantrine and quinidine), which are used to treat malaria. When Medcan is used in combination with halofantrine, it has resulted in increased blood levels of halofantrine due to an inhibitory effect on enzyme CYP3A4. It also increases the risk of heart rhythm disorder (prolonged QT interval, torsades de pointes). These medicines should not be taken together.

Antipsychotic Agent

There may be an interaction of Medcan with pimozide, which is used to treat mental disorders. When Medcan is used with this medicine, it increases the level of pimozide in the blood that may result in an abnormal and prolonged heartbeat. Avoid taking both the medicines together.

Antifungal Drugs

Medcan Capsule may interact with voriconazole, which is used to treat fungal infections. Monitoring of side-effects and damage related to voriconazole is recommended, particularly when voriconazole is started within 24 hour of the last dose of Medcan. Using both the medicines together should be avoided.

Oral Contraceptives

Medcan Capsule may interact with oral contraceptives, which are used to prevent pregnancy. When Medcan is used with these medicines, it affects the efficacy of oral contraceptives.

Antihypertensives

Special instructions need to be followed while taking this medicine along with losartan, which is used to treat high blood pressure. Medcan decreases the metabolism of this medicine. When using these medicines together, it is required to monitor blood pressure continuously.
Medcan Capsule interacts with sirolimus, which is used in organ transplantation to prevent rejection. Medcan increases the amount of sirolimus in the blood. The dose of this medicine should be adjusted when using in combination with Medcan.

Antiviral Drugs

There may be an interaction of Medcan with saquinavir and zidovudine, which are used in the treatment of viral infections. Medcan increases the exposure of drug to the body, maximun level of drug in the blood, and decreases clearance of saquinavir due to prevention of breakdown of saquinavir in liver. Use of Medcan may increase the duration of action of zidovudine. Dose adjustment is required in such cases.

Expired Medication

Taking a single dose of expired Medcan is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.

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