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Ixime Tablet

Generic Name(s): Cefixime

Why it's used

Ixime Tablet is used to treat certain bacterial infections including urinary tract infections, ear infections, throat infections including pharyngitis and tonsillitis, and sexually transmitted infections, such as, gonorrhea, that are affecting the urethra and rectum. Ixime is also used to treat worsening symptoms of severe cases of bronchitis.
When not to use
Ixime will not work to treat a viral infection, such as, a common cold or flu.
Cephalosporin Antibacterials
Ixime is a prescription medicine that belongs to a class of medicines called Cephalosporin Antibacterials. Cephalosporins are antibacterial medicines that kill bacteria by interfering with how bacteria build their cell walls.

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How to use

Read the medicine guide provided by your pharmacist, your doctor, or the medicine company. If you have any questions related to Ixime, ask your doctor or pharmacist. Use Ixime Tablet as per the instructions provided by your doctor.
Ixime is consumed with or without food.

Typical Dosage

The typical dose of Ixime for adults is 400 mg daily or 200 mg every 12 hours. The usual dose for children is 400 mg daily if weighing more than 50 kg (or 12 years and older). Children less than 12 years old and more than 6 months old are to be given 8 mg per kg of body weight of this medicine daily. Ixime is commonly used at the same time every day.
This medicine should be used on an as-needed basis. Ixime should be used as directed by the doctor even if you feel well, or even if you think that there is no need for you to use your medicine.
If you are using the chewable tablet form of this medicine, make sure you chew the medicine before you swallow it.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.

Talk to Your Doctor

Discuss with your doctor if your condition does not improve or worsens. If you have any kidney disease, a low dose may be recommended by your doctor. Consult with your doctor before stopping the use of Ixime.
Taking a higher dose of this medicine may increase the risk of side-effects.

Use in Children

If you are giving Ixime Tablet to a child, be sure to use a product that is for use in children. Use the child's weight or age to find the right dose from the product package or medicine label. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
Medicines may be recommended for uses other than those listed in the medicine guide. You should not use Ixime Tablet for conditions or symptoms for which it was not prescribed. Do not give Ixime Tablet to other people, even if they have the same conditions or symptoms that you have. The use of this medicine without the advice of a doctor may cause harm.

Storage

Follow storage instructions on the product package if available. Store Ixime Tablet at room temperature 20° to 25°C (68-77°F) away from heat, and away from moisture. Store this medicine away from children and pets.

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How to take Ixime

The dose and frequency of using Ixime will depend on the following factors:
  • age of the patient
  • the weight of the patient
  • patient's health
  • the health of the patient's liver
  • medicines recommended by the doctor
  • any other medicines being used
  • herbal supplements being used

Ixime Dosage

Dosage for uncomplicated urinary tract infections

Adult (adults)
  • Recommended: 400 mg/day
Children (6 months or older)
  • Recommended: 8 mg per kg/3.6 mg per lb of body weight daily for oral suspension
Children (children over 12 years or weighing more than 50 kg)
  • Recommended: 400 mg/day
Children (weight between 5 - 6.2 kg (11.03 - 13.67 lb))
  • Recommended: 2.5 ml daily (100 mg/5 ml suspension) or 1.25 ml daily (200 mg/5 ml suspension)
Children (weight between 6.3 - 12.5 kg (13.89 - 27.56 lb))
  • Recommended: 5 ml daily (100 mg/5 ml suspension) or 2.5 ml daily (200 mg/5 ml suspension)
Children (weight between 12.6 - 18.8 kg (27.78 - 41.45 lb))
  • Recommended: 7.5 ml daily (100 mg/5 ml suspension) or 3.75 ml daily (200 mg/5 ml suspension)
Children (weight between 18.9-25 kg (41.67-55.12 lb))
  • Recommended: 10 ml daily (100 mg/5 ml suspension) or 5 ml daily (200 mg/5 ml suspension)
Children (weight between 25.1-31.3 kg (55.34-69.01 lb))
  • Recommended: 12.5 ml daily (100 mg/5 ml suspension) or 6.25 ml daily (200 mg/5 ml suspension)
Children (weight between 31.4-37.5 kg (69.23-82.67 lb))
  • Recommended: 15 ml daily (100 mg/5 ml suspension) or 7.5 ml daily (200 mg/5 ml suspension)
Children (weight between 37.6 -43.8 kg (82.89-96.56 lb))
  • Recommended: 17.5ml daily (100 mg/5 ml suspension) or 8.75 ml daily (200 mg/5 ml suspension)
Children (weight between 43.9 to 50 kg (96.78-110.23 lb))
  • Recommended: 20ml daily (100 mg/5 ml suspension) or 10ml daily (200 mg/5 ml suspension)

Dosage for middle ear infections

Adult (adults)
  • Recommended: 400 mg/day
Children (6 months or older)
  • Recommended: 8 mg per kg/3.6 mg per lb of body weight daily for oral suspension
Children
  • Recommended: 400 mg daily

Dosage for throat infections (pharyngitis or tonsillitis)

Adult (adults)
  • Recommended: 400 mg daily
Children (6 months or older)
  • Recommended: 8 mg per kg/3.6 mg per lb of body weight daily for oral suspension
Children (children over 12 years or weighing more than 50 kg)
  • Recommended: 400 mg daily

Dosage for worsening of severe bronchitis

Adult (adults)
  • Recommended: 400 mg/day
Children (6 months or older)
  • Recommended: 8 mg per kg/3.6 mg per lb of body weight daily for oral suspension
Children (children over 12 years or weighing more than 50 kg)
  • Recommended: 400 mg daily

Dosage for sexually transmitted infections (gonorrhea)

Adult (adults)
  • Recommended: 400 mg/day
Children (6 months or older)
  • Recommended: 8 mg per kg/3.6 mg per lb of body weight daily for oral suspension
Children (children over 12 years or weighing more than 50 kg)
  • Recommended: 400 mg/day

Minimum Age

6 months

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 100 mg, 150 mg, 200 mg, 400 mg
Capsule
Strength: 100 mg, 150 mg, 200 mg, 400 mg
Oral suspension
Strength: 100 mg/5 ml, 200 mg/5 ml, 500 mg/5 ml
Chewable tablet
Strength: 100 mg, 150 mg, 200 mg, 400 mg

Missed Dose

Skip the missed dose and take the next dose as per your regular schedule.

Overdose

What to do if you overdose on Ixime?
An antidote is not available for Ixime. The effects of an overdose may be removed by the procedure called gastric lavage, which is used to clean out the contents of the stomach.
Symptoms of an overdose of Ixime
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Ixime Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Ixime

Before you use Ixime, tell your doctor of your medical and health history including the following:
  • an inherited disorder that causes an increase in the level of phenylalanine in the blood (phenylketonuria)
  • inflammation of the digestive tract (colitis)
  • kidney disease
  • liver disease
Treatment with Ixime changes the normal state of the colon leading to overgrowth of bacteria in the intestine. This may result in mild diarrhea or in the worst case even cause a fatal inflammatory condition of the intestines.
Before you use Ixime Tablet, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic to cephalosporin antibiotics, or penicillin antibiotics.

Use in Pregnancy

Ixime Tablet should be used in pregnancy only when required.

Use while Breastfeeding

Consult with your doctor on the use of Ixime during breastfeeding. It is unknown if this medicine passes into breast milk.

Impact on Fertility

Consult with your doctor on the use of Ixime Tablet, if you are trying to conceive.

Seizures

Ixime Tablet can make you feel sleepy. Be careful while driving, using machinery, or doing any other activity that needs you to be alert. The consumption of alcohol with Ixime Tablet can make you feel more sleepy. Ixime Tablet may cause seizures in some people. Discuss with your doctor if you perform activities where a loss of consciousness may cause you or others harm.

What precautions should be taken during Pregnancy and Nursing, and administering Ixime to Children or the Older Adults?

Pregnant Women

Only When Necessary
Warning: Ixime should be used in pregnancy only if it is needed because no adequate and well-controlled studies have been carried out.

Breastfeeding

Contraindicated or Not Recommended
Warning: It is unknown if this medicine passes into breast milk. Discontinue breastfeeding during treatment.

Younger Adults Population

Possibly safe
Warning: Ixime should not be used in children under the age of 6 months because the safety and effectiveness of this medicine in these patients have not been established.

Older Adults Population

Possibly safe
Warning: Ixime can be used in patients with 65 years, but sufficient data is not available regarding the use of this medicine in patients older than 65 years.

Ixime Side-effects

The following side-effects may commonly occur when using Ixime Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in children when using Ixime Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:
Rarely, the use of Ixime Tablet may cause the following side-effects:
  • an increase in the number of disease fighting white blood cells (eosinophilia)
  • blistering of the skin
  • decrease in the number of granulocytes, a type of white blood cells
  • dizziness
  • facial swelling
  • fever
  • headache
  • increase in platelet count
  • increase in prothrombin time
  • increase in the level of lactate dehydrogenase enzyme (LDH)
  • increase in the level of liver enzymes
  • inflammation in the kidney
  • itching of the skin
  • joint pain
  • liver disease
  • serious skin disorders
  • skin rashes
  • swelling of the lips, throat or tongue
  • temporarily increased level of waste products in the blood such as creatinine and blood urea nitrogen
  • vaginal itching
  • yeast infection
The following severe side-effects may also occur when using Ixime Tablet:
  • Inflammation of the colon (pseudomembranous colitis)
    Symptoms: severe watery diarrhea, feeling weak fever
    If this happens, contact your doctor right away and stop using this medicine.
  • Severe skin reaction
    Symptoms: fever, chill, muscle pain severe blistering rash on the skin
    If this happens, contact your doctor right away.
  • Disorder of the skin or mucous membrane called as Stevens-Johnson syndrome
    Symptoms: bleeding or blistering of the skin, flu-like symptoms fever
    If this happens, contact your doctor right away.
  • Brain disease called as encephalopathy
    Symptoms: convulsions, confusion lack of consciousness
    If this happens, contact your doctor right away.
  • Inflammation of the vagina, called as vaginitis
    Symptoms: itching in the vaginal area
    If this happens, contact your doctor right away.
  • Inflammation of the liver, called as hepatitis
  • An abnormal low level of a type of white blood cell (neutropenia)
  • Anemia due to an abnormal breakdown of the red blood cells (hemolytic anemia)
    Symptoms: nosebleeds, shortness of breath, bleeding gums, chills, pale skin tiredness
    If this happens, contact your doctor right away.
  • A deficiency of platelets, red blood cells and white blood cells called as pancytopenia
Your doctor has prescribed this Ixime because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Ixime.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Ixime by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:
  • angioedema
  • arthralgia
  • blistering of the skin
  • candidiasis
  • cholestasis
  • dizziness
  • drug fever
  • eosinophilia
  • face oedema
  • genital pruritus
  • granulocytopenia
  • headache
  • increase in the level of lactate dehydrogenase enzyme (LDH)
  • increase in the level of liver enzymes (serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase)
  • kidney transient elevation in blood urea nitrogen (BUN) and creatinine
  • prolongation in prothrombin time
  • pruritus
  • pyrexia
  • swelling of the lips, throat or tongue
  • thrombocytosis
  • tubulointerstitial nephritis
  • urticaria

Severe Side-effects

Following are the severe side-effects of this medicine:

Side-effects in Children

Following are the side-effects of this medicine in young patients:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
If an allergic reaction occurs, then discontinue the use of this medicine.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Severe Skin-Related Side-Effects

Patients with severe skin related side-effects are at increased risk with this medicine. These patients may see an increase in white blood cell counts in the body. Use of the medicine should be discontinued in such a case.

Prior Use of Ixime

Patients who are using this medicine again are at an increased risk with this medicine. These patients may have an increased risk of anemia.

Liver Dysfunction and Poor Nutritional State

Patients with abnormal liver functioning and poor nutritional state are at increased risk when using this medicine. Such patients may have an increased risk of fall in prothrombin time. Monitor prothrombin time carefully and take vitamin K as indicated by your doctor.

Strongly Suspected Bacterial Infection

Patients with strongly suspected bacterial infection are at increased risk when using Ixime. This medicine does not work against this type of infection.

Ixime Use with Other Antimicrobial Agents

Patients using Ixime and other antimicrobial agents are at increased risk using this medicine. Such patients are at increased risk of developing diarrhea. If the patient suffers from diarrhea, treatment including fluid/electrolytes, protein supplementation, antibiotics, and a surgical evaluation should be given to the patient.

Poor Functioning of Kidneys

Patients suffering from kidney related health issues are at increased risk when using this medicine. A fall in prothrombin activity may occur in these patients. This may indicate that your blood clots faster than normal and possibly cause serious health issues. Monitor prothrombin time carefully and your doctor may prescribe you to take vitamin K.

Prolonged Treatment with Antimicrobial Therapy

Patients with antimicrobial therapy are at increased risk when using this medicine. A fall in prothrombin activity may occur in these patients. Monitor prothrombin time carefully and take vitamin K as indicated by your doctor. A fall in prothrombin time indicates that your blood clots faster than normal and possibly cause serious health issues.

Interactions with Ixime

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Ixime Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Anticonvulsants

Ixime Tablet may interact with carbamazepine, which is used in the treatment of seizures. When using Ixime with carbamazepine, the level and effects of carbamazepine may increase in the body.

Anticoagulants

There may be an interaction of Ixime with warfarin, which is used to prevent blood clotting. When Ixime is taken with blood thinners, it increases blood clotting time. An increased blood clotting time may indicate a higher risk of bleeding.

Ketone Identification Test

Ixime Tablet interacts with a test for ketone identification in urine using nitroprusside. A false-positive result for the presence of ketones in the urine may occur.

Glucose Detection Test

Special instructions need to be followed while taking this medicine along with a test for presence of glucose in the urine using Benedict’s solution or Fehling’s solution. A false-positive reaction for glucose present in the urine may occur. It is recommended that glucose tests based on enzymatic glucose oxidase reactions should be used.

Coombs Test

Your doctor's guidelines may need to be followed while taking this medicine along with Coombs test, which is used to determine the presence of hemolytic anemia (abnormal breakdown of red blood cells). Wrong results for the Coombs test can occur when using this medicine.

Interactions of Ixime by Severity

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Ixime be not used?

Allergic to Ixime

Avoid this medicine in patients with known allergic reactions to the cephalosporins. Patients may have an increased risk of life-threatening allergic reaction (anaphylaxis). These patients may have the following symptoms if they use this medicine:

Clostridium Difficile Associated Diarrhea

This medicine should not be used in patients with bacterial (Clostridium difficile) associated diarrhea. This condition may further lead to the severe inflammatory condition of the intestine.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Ixime is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Ixime Tablet .
Urinary Tract Infections
Ear Infections
Streptococcal Infections
Gonorrhea

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