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Severe allergy

This medicine is not recommended in patients who are sensitive to Alprox or other benzodiazepines.

Azole anti-fungals, which are used to treat fungal infection

The use of Alprox with cytochrome P450 3A (CYP3A) inhibitors or azole anti-fungals (for example, ketoconazole and itraconazole), increases the amount of Alprox in the blood.

Patients with skeletal muscle weakness

The patients with skeletal muscle weakness are at increased risk while using this medicine.

Patients with severe respiratory insufficiency

The patients with severe respiratory insufficiency are at increased risk while using this medicine.

Patients with breathing problems during sleep (sleep apnoea syndrome)

The patients with breathing problems during sleep (sleep apnoea syndrome) are at increased risk while using this medicine.

Patients with abnormal functioning of the liver

The patients with abnormal functioning of the liver are at increased risk while using this medicine.

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