When two or more
medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a
Drug Interaction.
Alprox Tablet interacts with
imipramine and
desipramine, which are used to treat
depression. An increased amount of imipramine and desipramine in the blood have been reported when used simultaneously with Alprox.
There may be an interaction of
Alprox with other
brain depressants (CNS depressants). Alprox produces an additive effect when used with other brain depressants (CNS depressants) such as psychotropic medicines, neuroleptics, hypnotics, anti-anxiety drugs, sedatives,
antidepressants, narcotic
analgesics, anesthetics, anticonvulsants, and
antihistamines. The patient should be cautious when using Alprox with other brain depressants (CNS depressants).
Alprox Tablet may interact with
opioids, which are used to relieve
pain. The use of benzodiazepines and opioids together increases the risk of sedation, breathing insufficiency,
coma, and can be possibly fatal because of additive
brain depressant (central nervous system depressant) effect. It may also cause an increase in the experience of happiness or excitement which can lead to more mental dependence. If benzodiazepines and opioids are used together, limit the dosage and duration of treatment. Monitor the patients strictly for breathing insufficiency and sedation.
Your doctor's guidelines may need to be followed while taking this medicine along with
digoxin, which is used to treat heart failure. When Alprox is used with
digoxin, increased digoxin amount has been reported in the blood, especially in elderly aged more than 65 years. The patients who receive Alprox and digoxin should be monitored for signs and symptoms of increased digoxin levels in the blood.
Your doctor's guidelines may need to be followed while taking this medicine along with
cimetidine, which is used to treat
heartburn and stomach
ulcers. The use of Alprox with cimetidine increases the amount of Alprox in the blood. While using Alprox with cimetidine, precaution and dose reduction of Alprox is recommended.
Special instructions need to be followed while taking this medicine along with
nefazodone or
fluvoxamine, which are used to treat
depression. The use of nefazodone or fluvoxamine with Alprox cause a two-time increase in the level of Alprox in the blood and a decrease in psychomotor performance. The patients should be cautious while using Alprox with nefazodone or fluvoxamine and dose reduction is also recommended.
Alprox Tablet interacts with azole-type antifungals (for example,
ketoconazole,
itraconazole), which are used to treat fungal infection. The use of Alprox with azole anti-fungals (for example, ketoconazole and itraconazole), decreases the breakdown by
cytochrome P450 3A. This causes an increased amount of Alprox in the blood. The intake of Alprox with ketoconazole, itraconazole, or other azole-type antifungals is not recommended.
There may be an interaction of
Alprox with
HIV protease inhibitors (
ritonavir), which are used to treat viral infection. The use of ritonavir with Alprox results in decreased Alprox elimination from the body and enhanced clinical effects. When HIV protease inhibitors are used with Alprox, a dose-adjustment or discontinuation of Alprox is needed.
Alprox Tablet interacts with
isoniazid or
paroxetine, which are used to treat infection and
depression respectively. While using Alprox with isoniazid and paroxetine, caution is recommended.
There may be an interaction of
Alprox with
ergotamine,
amiodarone,
nicardipine,
cyclosporine, and
nifedipine, which are used to treat
migraine type
headache, irregular heartbeat, high blood pressure, to prevent organ rejection and certain types of chest
pain respectively. While using Alprox with ergotamine, amiodarone, nicardipine,
cyclosporine, or
nifedipine caution should be taken.
This page does not contain all the possible interactions of Alprox Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any
medicines without the approval of your doctor.