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Polysporin Ointment is used for Bacterial infections, Respiratory infections, Urinary tract infection, Conjunctivitis and other conditions. Polysporin Ointment may also be used for purposes not listed in this medication guide.
Polysporin Ointment contains Polymyxin B and Polymyxin B Sulphate as active ingredients.
Polysporin Ointment works by killing the sensitive bacteria; killing the bacteria;
Detailed information related to Polysporin Ointment's uses, composition, dosage, side effects and reviews is listed below.


Polysporin Ointment is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
Learn more: Uses

Polysporin Ointment Side-effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Polysporin Ointment. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
Learn more: Side-effects


Before using Polysporin Ointment, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
  • Consult your doctor before using in pregnancy or breastfeeding
  • Consult your doctor if you get watery and bloody stools
  • Do not drive or operate machinery
  • Do not drive or operate machinery after consuming the medicine
  • Monitor eye pressure
  • Monitor renal functions
  • Pregnant, planning to get pregnant or breastfeeding
  • Remove the contact lenses before applying the eye drops
  • do not take by mouth. Consult with your doctor before using this medicine on open wounds, dry, chapped, irritated, or sun-burned skin.
  • wash your hands before and after applying Polysporin Ointment. Clean and dry the skin area to be treated.
  • do not wash the treated area after immediately applying Polysporin Ointment. Also avoid the use of other products on the treated area unless directed by your doctor.
  • applying an excessive amount may result in pilling. Use a thinner layer or lesser quantity of medicine to avoid pilling.
  • avoid getting this medication in your eyes or nose or mouth.

Interactions with Polysporin Ointment

If you use other drugs or over the counter products at the same time, the effects of Polysporin Ointment may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Polysporin Ointment may interact with the following drugs and products:
  • Alcuronium
  • Amphotericin B
  • Atracurium
  • Botulinum toxin type A
  • Capreomycin
  • Cephalothin
  • Distigmine
  • Floxacillin
  • Gentamicin
  • Neomycin
Learn more: Interactions

When not to use Polysporin Ointment

Hypersensitivity to Polysporin Ointment is a contraindication. In addition, Polysporin Ointment should not be used if you have the following conditions:
Learn more: Contraindications

Composition and Active Ingredients

Polysporin Ointment is composed of the following active ingredients (salts)
Please note that this medicine may be available in various strengths for each active ingredient listed above.

Packages and Strengths

Polysporin Ointment is available in the following packages and strengths
Polysporin Ointment - Packages: 15

Polysporin Ointment - Frequently asked Questions

  • Is Polysporin Ointment safe to use when pregnant?
    • Polymyxin B Sulphate: Please consult with your doctor for case-specific recommendations.
    • Polymyxin B: Please consult with your doctor for case-specific recommendations.
  • Is Polysporin Ointment safe while breastfeeding?
    • Polymyxin B Sulphate: Please discuss the risks and benefits with your doctor.
    • Polymyxin B: Please discuss the risks and benefits with your doctor.
  • Can Polysporin Ointment be used for Bacterial infections and Respiratory infections?
    Yes, bacterial infections and respiratory infections are among the most common reported uses for Polysporin Ointment. Please do not use Polysporin Ointment for bacterial infections and respiratory infections without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Polysporin Ointment.
  • Is it safe to drive or operate heavy machinery when using this product?
    If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Polysporin Ointment medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Polysporin Ointment. Always consult with your doctor for recommendations specific to your body and health conditions.
  • Is this medicine or product addictive or habit forming?
    Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
  • Can i stop using this product immediately or do I have to slowly ween off the use?
    Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Other important Information on Polysporin Ointment

Missing a dose

In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.

Overdosage of Polysporin Ointment

  • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Polysporin Ointment, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
  • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
  • Please consult your physician or pharmacist or product package for more information.

Storage of Polysporin Ointment

  • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
  • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Polysporin Ointment.

Expired Polysporin Ointment

  • Taking a single dose of expired Polysporin Ointment is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.

Dosage Information

Please consult your physician or pharmacist or refer to product package.

Cite this page

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APA Style Citation

  • Polysporin Ointment - Uses, Side-effects, Reviews, and Precautions - Johnson And Johnson - TabletWise - South Africa. (n.d.). Retrieved August 19, 2019, from

MLA Style Citation

  • "Polysporin Ointment - Uses, Side-effects, Reviews, and Precautions - Johnson And Johnson - TabletWise - South Africa" N.p., n.d. Web. 19 Aug. 2019.

Chicago Style Citation

  • "Polysporin Ointment - Uses, Side-effects, Reviews, and Precautions - Johnson And Johnson - TabletWise - South Africa" Tabletwise. Accessed August 19, 2019.

Last updated date

This page was last updated on 11/15/2017.
This page provides information for Polysporin Ointment in English.

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