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Why it's used

Rocephin Injection is a prescription medicine that is used to treat certain types of pneumonia and infections. It is also used to treat sexually transmitted diseases such as gonorrhea and syphilis and respiratory symptoms such as coughing and shortness of breath. This medicine works by weakening the outermost layer of bacteria which leads to the breakdown of the bacterial cells. This medicine helps by killing bacteria in the body. Rocephin Injection is also used to prevent infection of the female reproductive organs, to reduce infections before surgery, and for the management of a decreased number of neutrophils and fever due to bacterial infection.
When not to use
Rocephin Injection will not work to treat viral infections such as common cold.
Cephalosporin Antibacterials
Rocephin belongs to the Cephalosporin Antibacterials class of medicines. Cephalosporins are antibacterial medicines that kill bacteria by interfering with how bacteria build their cell walls.

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How to use

Follow directions on the product label, information guide, and provided by your doctor before using Rocephin. Inject this medicine as per your doctor's instructions.

Typical Dosage

The typical adult dose of Rocephin is 1-2 g once a day (not more than 4 g in one day). The maximum dose for adults of Rocephin is 4 g per day. This medicine is commonly used for a period of at least 10 days for infection caused by Streptococcus pyogenes bacteria, 7-14 days for meningitis, 3 days for middle ear infection, and 10-14 days for syphilis.
This medicine should be used on an as-needed basis. Rocephin may be used for a long time to treat complicated infections. You should continue to use this medicine as directed by the doctor even if you feel well.
The injection form of the medicine may be used on the large muscles. Rocephin injection is directly injected into muscles (intramuscular) and into veins (intravenous) route.
If you have any kidney disease, a daily dose of Rocephin should not be increased by more than 2 g in case of kidney failure. Consult with your doctor before stopping the use of Rocephin Injection.
Older patients may see an increase in the risk of side-effects. Hence, a lower dose may be recommended.

Use in Children

If you are giving Rocephin Injection to a child, be sure to use a product that is meant for use in children. Before giving this medicine, use the child's weight or age to find the right dose from the leaflet or product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Storage

Store Rocephin Injection at room temperature 25°C (77°F), and away from light. Keep this medicine away from children and pets.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Rocephin Injection for symptoms for which it was not prescribed. Do not give Rocephin Injection to others who may have similar symptoms as you. Self-medication can cause harm.

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How to take Rocephin

Your dose and how often you take Rocephin will depend on the following factors:
  • age
  • weight
  • patient's health
  • the health of the patient's liver
  • medicines recommended by the doctor
  • any other medicines being used

Rocephin Dosage

Dosage for community-acquired pneumonia

Adult (adults and children above 12 years (greater than or equal to 50 kg/110.23 lbs))
  • Recommended: 1000-2000 mg once daily
Children (neonates, infants and children of 15 days-12 years (less than 50 kg/110.23 lbs))
  • Recommended: 50-80 mg/kg (22.68-36.28 mg/lb) once a day
Children (neonates of age 0-14 days)
  • Recommended: 20-50 mg/kg (9.07-22.68 mg/lb) once daily
  • Maximum: 50 mg/kg/day (22.68 mg/lb/day)

Dosage for gonorrhea

Adult
  • Recommended: 250 mg as a single intramuscular dose

Dosage for the prevention of infections before surgery

Adult
  • Recommended: 1000 mg as a single dose injected directly into the vein (1/2 to 2 hours before surgery)
Children (neonates, infants and children of 15 days-12 years (less than 50 kg))
  • Recommended: 50-80 mg/kg (22.68-36.28 mg/lb) as a single dose
Children (neonates of age 0-14 days)
  • Recommended: 20-50 mg/kg (9.07-22.68 mg/lb) as a single dose

Dosage for middle ear infection (otitis media)

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 1000-2000 mg once daily
Children (neonates, infants and children of age 15 days-12 years (less than 50 kg))
  • Recommended: 50 mg/kg/day (22.68 mg/lb/day)
  • Maximum: 1000 mg/day
Children
  • Initial: 50 mg/kg (22.68 mg/lb) as a single dose
  • Maximum: neonates of age 0-14 days

Dosage for skin infections

Adult (adults and children above 12 years (greater than or equal to 50 kg))
  • Recommended: 2000 mg once daily
Children (neonates, infants and children of 15 days-12 years (less than 50 kg/110.23 lbs))
  • Recommended: 50-100 mg/kg (22.68-45.36 mg/lb) once daily
  • Maximum: 4000 mg once daily
Children (neonates of age 0-14 days)
  • Recommended: 20-50 mg/kg (9.07-22.68 mg/lb) once daily
  • Maximum: 50 mg/kg (22.68 mg/lb) once daily

Dosage for urinary tract infections

Adult (adults and children above 12 years (greater than or equal to 50 kg))
  • Recommended: 1000-2000 mg once daily
Children (neonates, infants and children of 15 days-12 years (less than 50 kg/110.23 lbs))
  • Recommended: 50-80 mg/kg (22.68-36.28 mg/lb) once daily
Children (neonates of age 0-14 days)
  • Recommended: 20-50 mg/kg (9.07-22.68 mg/lb) once daily
  • Maximum: 50 mg/kg/day (22.68 mg/lb/day)

Dosage for decreased number of neutrophils and fever

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 2000-4000 mg once daily
Children (neonates, infants and children of 15 days-12 years (less than 50 kg))
  • Recommended: 50-100 mg/kg (22.68-45.36 mg/lb) once daily
  • Maximum: 4000 mg once daily
Children (neonates of age 0-14 days)
  • Recommended: 20-50 mg/kg (9.07-22.68 mg/lb) once daily
  • Maximum: 50 mg/kg/day (22.68 mg/lb/day)

Dosage for insect bite infection

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 2000 mg once daily for 14-21 days
Children (neonates, infants and children of 15 days-12 years (less than 50 kg/110.23 lbs))
  • Recommended: 50-80 mg/kg (22.68-36.28 mg/lb) once daily for 14-21 days

Dosage for bone and joint infections

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 2000 mg once daily
Children (neonates, infants and children of 15 days-12 years (less than 50 kg))
  • Recommended: 50-100 mg/kg (22.68-45.36 mg/lb) once daily
  • Maximum: 4000 mg once daily
Children (neonates of age 0-14 days)
  • Recommended: 20-50 mg/kg (9.07-22.68 mg/lb) once daily
  • Maximum: 50 mg/kg/day (22.68 mg/lb/day)

Dosage for intra-abdominal infections

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 1000-2000 g once daily
Children (neonates, infants and children of 15 days-12 years (less than 50 kg/110.23 lbs))
  • Recommended: 50-80 mg/kg (22.68-36.28 mg/lb) once daily
Children (neonates of age 0-14 days)
  • Recommended: 20-50 mg/kg (9.07-22.68 mg/lb) once daily
  • Maximum: 50 mg/kg/day (22.68 mg/lb/day)

Dosage for brain and spinal cord inflammation

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 2000-4000 mg once daily
Children (neonates, infants and children of 15 days-12 years (less than 50 kg))
  • Recommended: 80-100 mg/kg (36.28-45.36 mg/lb) once daily
  • Maximum: 4000 mg once daily
Children (neonates of age 0-14 days)
  • Recommended: 50 mg/kg (22.68 mg/lb) once daily
  • Maximum: 50 mg/kg/day (22.68 mg/lb/day)

Dosage for hospital-acquired pneumonia

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 2000 mg once daily
Children (neonates, infants and children of 15 days-12 years (less than 50 kg))
  • Recommended: 50-80 mg/kg (22.68-36.28 mg/lb) once daily
Children (neonates of age 0-14 days)
  • Recommended: 20-50 mg/kg (9.07-22.68 mg/lb) once daily
  • Maximum: 50 mg/kg/day (22.68 mg/lb/day)

Dosage for syphilis

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 500 mg-1000 mg once daily and 2000 mg once daily for neurosyphilis for 10-14 days
Children (neonates, infants and children of 15 days-12 years (less than 50 kg))
  • Recommended: 75-100 mg/kg (34.02-45.36 mg/lb) once daily for 10-14 days
  • Maximum: 4000 mg once daily for 10-14 days
Children (neonates of age 0-14 days)
  • Recommended: 50 mg/kg (22.68 mg/lb) once daily for 10-14 days

Dosage for worsening of respiratory symptoms

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 1000-2000 mg once daily

Dosage for infection of the inner part of the heart

Adult (adults and children over 12 years (greater than or equal to 50 kg))
  • Recommended: 2000-4000 mg once daily
Children (neonates, infants and children of 15 days-12 years (less than 50 kg/110.23 lbs))
  • Recommended: 100 mg/kg (45.36 mg/lb) once daily
  • Maximum: 4000 mg once daily
Children (neonates of age 0-14 days)
  • Recommended: 50 mg/kg (22.68 mg/lb) once daily
  • Maximum: 50 mg/kg (22.68 mg/lb) once daily

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Powder for Injection
Strength: 1 g, 2g

Special Instructions

Intramuscular/Intravenous injection
The drug products which are injected directly into muscles and veins should be tested visually for the presence of solid particles into the solution for injection.

Missed Dose

If you miss an injection, you should get it as soon as you remember it. And if it is almost the time for your next injection, skip the missed one.

Overdose

What to do if you overdose on Rocephin?
No specific antidote is available for an overdose of Rocephin. However, the treatment according to the symptoms should be given immediately.
Symptoms of an overdose of Rocephin
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Rocephin Injection, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Rocephin

Before you use Rocephin, tell your doctor of your medical and health history including the following:
  • abnormal functioning of the liver
  • gastrointestinal disease (such as colitis)
  • kidney disease
Before you use Rocephin Injection, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic to beta-lactam antibacterial agent (penicillins, carbapenems, and monobactams).
The use of this medicine may change blood clotting time. In such patients, alterations in blood clotting time may occur.

Use in Pregnancy

Rocephin Injection should be used in pregnancy only when required.

Use while Breastfeeding

Rocephin may pass into the breast milk in low amount.

Impact on Fertility

Consult with your doctor on the use of Rocephin Injection, if you are trying to conceive.

Seizures

Rocephin Injection can make you feel sleepy. Be careful while driving, using machinery, or doing any other activity that needs you to be alert. The consumption of alcohol with Rocephin Injection can make you feel more sleepy. Rocephin Injection may cause seizures in some people. Discuss with your doctor if you perform activities where a loss of consciousness may cause you or others harm.

What precautions should be taken during Pregnancy and Nursing, and administering Rocephin to Children or the Older Adults?

Pregnant Women

Only When Necessary
Warning: Rocephin should be used in pregnancy only if it is needed because no adequate and well-controlled studies have been carried out.

Breastfeeding

Precaution
Warning: Rocephin may pass into the breast milk in low amount.

Younger Adults Population

Possibly safe
Warning: This medicine can displace the bilirubin from blood albumin.

Older Adults Population

Possibly safe
Warning: 

Rocephin Side-effects

The following side-effects may commonly occur when using Rocephin Injection. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
  • diarrhea
  • increase in the level of liver enzymes
  • increased number of white blood cells
  • low levels of platelets in the blood
  • skin rash
  • the decrease in the number of white blood cells
Rarely, the use of Rocephin Injection may cause the following side-effects:
The following severe side-effects may also occur when using Rocephin Injection:
  • increase in the number of white blood cells (leukocytosis)
  • low levels of thrombocytes
  • calcium salt precipitation in kidneys and lungs in newborn babies (possibly fatal)
  • reoccurrence of a new infection while using an antibiotic (superinfection)
  • Clostridium difficile associated diarrhea
    Symptoms: watery and bloody stools, stomach cramps fever
    If these symptoms happen, patients should contact their doctor as soon as possible.
  • the decrease in the number of white blood cells (leukopenia)
  • severe skin reactions (Stevens-Johnson syndrome or Lyell's syndrome)
  • blood loss due to a ruptured blood vessel (hemorrhage)
  • life-threatening allergic reactions (anaphylaxis)
Your doctor has prescribed Rocephin Injection because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Rocephin Injection.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Rocephin by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
In case of severe allergic reactions, subcutaneous epinephrine and other emergency measures may be used.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Interference with Serological Testing

Use of Rocephin may lead to false positive results for the determination of glucose in urine. An alternative testing method should be followed to avoid false positive results.

Allergy to Rocephin

Patients who are allergic to Rocephin are at an increased risk. Such patients may see an increased risk of life-threatening allergic reactions such as Stevens-Johnson syndrome or Lyell's syndrome. These patients should discontinue the use of this medicine.

Abnormal Functioning of the Liver and Kidneys

Such patients are at an increased risk when using this medicine. Careful clinical monitoring of safety and efficacy data is advisable for Rocephin.

Kidney Problems

Patients with a history of kidney stone and excessive urinary calcium excretion are at an increased risk when using this medicine. In such patients, the kidney stone may occur upon discontinuation of Rocephin.

Treatment With Rocephin

Patients treated with this medicine are at an increased risk of inflammation of the pancreas (pancreatitis).

Use of Rocephin Sodium

Patients, who use Rocephin sodium are at increased risk. Such patients should follow a controlled sodium diet.

Long-Term Treatment with Rocephin

Patients on long-term treatment with cephalosporins are at an increased risk when using this medicine. In such patients, complete blood count should be checked regularly.

Use of Antibacterial Medicines

Patients who use antibacterial medicines including Rocephin are at increased risk. In such patients, severe diarrhea may occur which is caused by Clostridium difficile bacteria. If this happens, stop using this medicine and take protein supplements or maintain the balance of body fluid and electrolyte (example sodium, chloride, potassium, and bicarbonate).

Hemolytic Anemia

Patients receiving cephalosporins are at an increased risk of abnormal breakdown of red blood cells (hemolytic anemia). Such patients may see an increased risk of fatal conditions both in adults and children. If this happens, stop using this medicine until its cause is determined.

Interaction with Calcium-Containing Solution

Patients, who use calcium-containing solution to prepare the injection are at high risk. When the injection of this medicine is prepared with calcium-containing solutions, then it may lead to an increased risk of formation of solid calcium particles. Do not use calcium-containing solutions (such as Ringer’s solution or Hartmann’s solution) for preparing the injection.

Interactions with Rocephin

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Rocephin Injection. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Coombs' Test

Rocephin Injection may interact with Coombs' test, which is used to check blood for antibodies that attack red blood cells. A false positive result of the Coombs test can occur when using this medicine. An alternative testing method should be followed to avoid false positive results.

Galactose Interference in the Blood

There may be an interaction of Rocephin with interference with galactose determination in blood. A false positive result of the galactosemia can occur when using this medicine.

Galactose Interference in the Urine

Rocephin Injection interacts with interference with glucose determination in urine. When using a non-enzymatic method for the determination of glucose in urine, a false-positive result may occur. For this reason, when using this medicine glucose level in urine should be determined according to enzyme activity.

Calcium-Containing Solution

Special instructions need to be followed while taking this medicine along with a calcium-containing solution for preparing the injection. When the injection of this medicine is prepared with calcium-containing solutions, then it may lead to an increased risk of formation of solid calcium particles. Do not use calcium-containing solutions (such as Ringer’s solution or Hartmann’s solution) for preparing an injection of Rocephin.

Anticoagulants

Your doctor's guidelines may need to be followed while taking this medicine along with anticoagulants, which are used to prevent blood clotting. Such patients may have an increased risk of bleeding. Proper monitoring of blood clotting time and dose adjustment is required in patients undergoing therapy with both anticoagulants and Rocephin.

Aminoglycosides

Rocephin Injection may interact with aminoglycosides, which are used to treat bacterial infections. When aminoglycosides are taken with cephalosporins, it may lead to an increased risk of kidney damage. In such cases, carefully monitor the levels of aminoglycosides in the blood.

Chloramphenicol

There may be an interaction of Rocephin with chloramphenicol, which is used to treat bacterial infections. Both the medicines oppose (antagonize) the working of each other.

Interactions of Rocephin by Severity

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Rocephin be not used?

Allergy to Rocephin

This medicine should not be given to the patients with known allergic reaction to the cephalosporin class of antibiotics. These patients may have the following symptoms if they use this medicine:

Newborn Babies

The newborn babies (age less than and equal to 28 days) with a high level of bilirubin should not be treated with Rocephin. Patients may see an increased risk of bilirubin-induced brain dysfunction and low levels of albumin in blood.

Newborns Required Calcium-Containing Injections

This medicine should not be used in babies who require continuous calcium-containing injections. Neonates may see an increased risk of fatal outcomes.

Use of Lidocaine

This medicine should not be injected directly into muscles when its solution contains lidocaine.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Rocephin is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Rocephin Injection .
Bacterial Infections
Pneumonia
Skin Infections
Urinary Tract Infections

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